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Restoration of nuclear-import failure caused by triple A syndrome and oxidative stress.

Abstract：

:Triple A syndrome is an autosomal recessive neurological disease, mimicking motor neuron disease, and is caused by mutant ALADIN, a nuclear-pore complex component. We recently discovered that the pathogenesis involved impaired nuclear import of DNA repair proteins, including DNA ligase I and the cerebellar ataxia causative protein aprataxin. Such impairment was overcome by fusing classical nuclear localization signal (NLS) and 137-aa downstream sequence of XRCC1, designated stretched NLS (stNLS). We report here that the minimum essential sequence of stNLS (mstNLS) is residues 239-276, downsized by more than 100 aa. mstNLS enabled efficient nuclear import of DNA repair proteins in patient fibroblasts, functioned under oxidative stress, and reduced oxidative-stress-induced cell death, more effectively than stNLS. The stress-tolerability of mstNLS was also exerted in control fibroblasts and neuroblastoma cells. These findings may help develop treatments for currently intractable triple A syndrome and other oxidative-stress-related neurological diseases, and contribute to nuclear compartmentalization study.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Kiriyama T,Hirano M,Asai H,Ikeda M,Furiya Y,Ueno S

doi

10.1016/j.bbrc.2008.07.088

subject

Has Abstract

pub_date

2008-10-03 00:00:00

pages

631-4

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(08)01392-2

journal_volume

374

pub_type

杂志文章

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