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Effect of an inhibitor of protein kinase C on human polymorphonuclear leukocyte degranulation.

Abstract：

:The protein kinase C inhibitor C-I reduced superoxide production by human neutrophils in response to phorbol myristate acetate by greater than 50%. In contrast to its effects in oxidative metabolism, 100 microM C-I caused minimal inhibition (5-18%) of lysozyme release in response to phorbol myristate acetate. Enzyme release produced by the formylated oligopeptide FMLP was enhanced by 23-54% in neutrophils pretreated with 100 microM C-I. These findings suggest that protein kinase C activation is not required for phorbol myristate acetate induced enzyme release. Enhancement of FMLP stimulated degranulation by C-I suggests that protein kinase C activation may have inhibitory effects on the release of granule enzymes by human neutrophils.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Salzer W,Gerard C,McCall C

doi

10.1016/0006-291x(87)90939-9

subject

Has Abstract

pub_date

1987-10-29 00:00:00

pages

747-54

issue

2

eissn

0006-291X

issn

1090-2104

pii

0006-291X(87)90939-9

journal_volume

148

pub_type

杂志文章

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