Abstract:
:Osteopontin (OPN) is involved in exacerbating various inflammatory diseases. A severe pulmonary inflammation is frequently found in lethal influenza A virus (IAV) infection. However, the function of OPN against the infection was poorly understood. Here, we demonstrate an importance of OPN on immune response and disease severity after IAV infection. We found that the expression level of OPN was increased in mice infected with IAV. The OPN knockout (KO) mice exhibited a severe pathological phenotype and the survival rate decreased after the lethal IAV infection, compared to the wild type mice, while the survival rate increased in OPN transgenic (Tg) mice. The population of natural killer (NK) cells significantly decreased in OPN KO mice at day 5 after the infection, whereas, it increased in OPN Tg mice. These results suggest that OPN plays an important role in host defense against IAV infection through the regulation of NK cell population.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Sato K,Iwai A,Nakayama Y,Morimoto J,Takada A,Maruyama M,Kida H,Uede T,Miyazaki Tdoi
10.1016/j.bbrc.2011.11.100subject
Has Abstractpub_date
2012-01-06 00:00:00pages
274-9issue
1eissn
0006-291Xissn
1090-2104pii
S0006-291X(11)02121-8journal_volume
417pub_type
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