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Trehalose targets Nrf2 signal to alleviate d-galactose induced aging and improve behavioral ability.

Abstract：

:As an important factor leading to aging and chronic diseases, oxidative stress has become a hot research topic. Trehalose is a natural sugar widely found in many edible plants, animals and natural microorganisms, and recent studies have suggested that trehalose is an antioxidant, although its underlying molecular mechanism is unclear. Therefore, we evaluated the protective mechanism of trehalose against oxidative stress-induced senescence. In the mouse model of d-galactose (D-gal) induced aging, we found that trehalose significantly reversed the learning and memory impairment caused by D-gal and improved the ability to explore unknown things, which was associated with a significant reduction in brain tissue damage. Further studies have shown that trehalose activates the expressions of downstream target genes HO-1, NQO1, SOD, GSH and CAT by promoting the nuclear translocation of Nrf2 in the liver. The detoxification ability of organs is increased, antioxidant enzyme activity is enhanced, lipid peroxidation is reduced, and the secretion of inflammatory factors TNF-α, IL-1β, il-6 is decreased. In conclusion, trehalose play an anti-aging role by activating genes related to Nrf2 pathway.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Sun L,Zhao Q,Xiao Y,Liu X,Li Y,Zhang J,Pan J,Zhang Z

doi

10.1016/j.bbrc.2019.10.088

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

113-119

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(19)31981-3

journal_volume

521

pub_type

杂志文章

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