Specific interaction of pRB with a rat genomic DNA fragment, REC11.

abstract：:CPI-17 is a protein phosphatase 1 (PP1) inhibitor that has been shown to act on the myosin light chain phosphatase. CPI-17 is phosphorylated on Thr-38 in vivo, thus enhancing its ability to inhibit PP1. Thr-38 has been shown to be the target of several protein kinases in vitro. Originally, the expression of CPI-17 was...

journal_title：Biochemical and biophysical research communications

authors： Dubois T,Howell S,Zemlickova E,Learmonth M,Cronshaw A,Aitken A

更新日期：2003-03-07 00:00:00

abstract：:The Monte Carlo method has been used to simulate the equilibrium properties of a planar array of 94 saturated lipid chains and one monomer of Gramicidin A. Chains are free to move laterally in the layer plane and to change conformation via gauche rotations and long axis rotations in a continuum. All non-hydrogen atoms...

journal_title：Biochemical and biophysical research communications

authors： Xing J,Scott HL

更新日期：1989-11-30 00:00:00

abstract：:Two genomic clones containing the 3'-end of CYP3A7, the whole 5'-flanking region plus the first exon of CYP3A5 were isolated from two different human genomic banks and sequenced. The 5'-flanking region of CYP3A5, from nucleotide -1 to -1434, was 60% and 59% similar with the corresponding regions of CYP3A4 and CYP3A7, ...

journal_title：Biochemical and biophysical research communications

authors： Jounaïdi Y,Guzelian PS,Maurel P,Vilarem MJ

更新日期：1994-12-30 00:00:00

abstract：:In our previous studies, we have demonstrated that a stretch of amino-acid sequences identified from Arabidopsis ribosomal S6 kinase 1 (AtS6K1) provided a plant version of the TOS (TOR-signaling) motif, mediating the interaction with the Raptor protein in the TOR (Target of Rapamycin) kinase complex. Here we report th...

journal_title：Biochemical and biophysical research communications

authors： Son O,Kim S,Kim D,Hur YS,Kim J,Cheon CI

更新日期：2018-06-27 00:00:00

abstract：:Mitochondrial uncoupling proteins (UCPs) have been postulated to be regulators of thermogenesis, energy balance, and oxidative stress. Brain mitochondrial carrier protein-1 (BMCP1) is a new member of the UCP family, but little is known about the gene regulation and the role of BMCP1 in the central nervous system. In t...

journal_title：Biochemical and biophysical research communications

authors： Mizuno T,Miura-Suzuki T,Yamashita H,Mori N

更新日期：2000-11-30 00:00:00

abstract：:Chlorpromazine is a potent inhibitor of calmodulin and can alter the accumulation, metabolism, and incorporation into RNA of several fluoropyrimidine drugs. Using S-180 murine sarcoma cells, the accumulation of the base Fluorouracil and its metabolism to ribonucleotides is enhanced by chlorpromazine treatment, as meas...

journal_title：Biochemical and biophysical research communications

authors： Tseng A Jr,Brooks M,Cadman E

更新日期：1986-07-31 00:00:00

abstract：:Aminopeptidase B (Ap-B) is a Zn2+-aminopeptidase of the M1 family which is implicated, in conjunction with the nardilysin endoprotease, in the generation of miniglucagon, a peptide involved in the maintenance of glucose homeostasis. Other in vivo physiological roles have been established for this vertebrate enzyme, su...

journal_title：Biochemical and biophysical research communications

authors： Cadel S,Darmon C,Désert A,Mahbouli M,Piesse C,Ghélis T,Lafont R,Foulon T

更新日期：2019-05-14 00:00:00

abstract：:The organisms have the capacity to sense and adapt to their surroundings for their life in a dynamic environment. In response to amino acid starvation, cells activate a rectifying physiological program, termed the integrated stress response (ISR), to restore cellular homeostasis. General controlled non-repressed (GCN2...

journal_title：Biochemical and biophysical research communications

authors： Kim K,Park JE,Yeom J,Park N,Trần TT,Kang MJ

更新日期：2020-12-17 00:00:00

abstract：:HMGB1 (high-mobility group B1) is a ubiquitously expressed bifunctional protein that acts as a nuclear protein in cells and also as an inflammatory mediator in the extracellular space. HMGB1 changes its functions according to the redox states in both intra- and extra-cellular environments. Two cysteines, Cys23 and Cys...

journal_title：Biochemical and biophysical research communications

authors： Wang J,Tochio N,Takeuchi A,Uewaki J,Kobayashi N,Tate S

更新日期：2013-11-29 00:00:00

abstract：:Parathyroid hormone (PTH)/parathyroid hormone-related peptide (PTHrP) receptor expressed in rat cultured cortical type I astrocytes was identified and characterized. Northern blot analysis demonstrated that the PTH/PTHrP receptor mRNA is expressed in astrocytes. A human PTH fragment, PTH [1-34], stimulated adenylate c...

journal_title：Biochemical and biophysical research communications

authors： Hashimoto H,Aino H,Ogawa N,Nagata S,Baba A

更新日期：1994-04-29 00:00:00

abstract：:The downregulation of gene expression by RNA interference holds great potential for genetic analysis and gene therapy. However, a more efficient delivery system for small interfering RNA (siRNA) into the target cells is required for wide fields such as cell biology, physiology, and clinical application. Non-viral vect...

journal_title：Biochemical and biophysical research communications

authors： Inoh Y,Furuno T,Hirashima N,Kitamoto D,Nakanishi M

更新日期：2011-10-28 00:00:00

abstract：:The thermophilic, obligately chemolithoautotrophic hydrogen-oxidizing bacterium, Hydrogenobacter thermophilus TK-6, assimilates carbon dioxide via the reductive tricarboxylic acid cycle. A gene cluster, porEDABG, encoding pyruvate:ferredoxin oxidoreductase (POR), which plays a key role in this cycle, was cloned and se...

journal_title：Biochemical and biophysical research communications

authors： Ikeda T,Ochiai T,Morita S,Nishiyama A,Yamada E,Arai H,Ishii M,Igarashi Y

更新日期：2006-02-03 00:00:00

abstract：BACKGROUND:Quercetin is a plant polyphenol from the flavonoid group that plays a fundamental role in controlling homeostasis due to its potent antioxidant properties. However, quercetin has extremely low water solubility, which is a major challenge in drug absorption. METHOD:In this study, we described a simple method...

journal_title：Biochemical and biophysical research communications

authors： Aghapour F,Moghadamnia AA,Nicolini A,Kani SNM,Barari L,Morakabati P,Rezazadeh L,Kazemi S

更新日期：2018-06-12 00:00:00

abstract：:Recently, the concern that toluene might have carcinogenic and reproductive toxic potential has been raised. We investigated the ability of DNA damage by minor metabolites of toluene, methylhydroquinone, and methylbenzoquinone, using (32)P-5'-end-labeled DNA fragments obtained from the human genes. Methylhydroquinone ...

journal_title：Biochemical and biophysical research communications

authors： Murata M,Tsujikawa M,Kawanishi S

更新日期：1999-08-02 00:00:00

abstract：:We recently reported that oviduct epithelial cells in culture produce endothelin (ET) and postulated that ET could play an important role in the contraction of the oviduct. In the present study using an organ chamber myograph system, we evaluated the contractile effects of ET-1 on bovine oviduct ampullary-isthmus segm...

journal_title：Biochemical and biophysical research communications

authors： Rosselli M,Imthurn B,Macas E,Keller PJ,Dubey RK

更新日期：1994-05-30 00:00:00

abstract：:Electrophoretic mobility shift assays revealed minimal levels of NF-kappaB activity in rat distal lung epithelial cells cultured at fetal (23 mmHg) or adult alveolar (100 mmHg) P(O2), but revealed significant activation of this transcription factor in cells exposed to a rise in P(O2) mimicking that experienced at birt...

journal_title：Biochemical and biophysical research communications

authors： Haddad JJ,Collett A,Land SC,Olver RE,Wilson SM

更新日期：2001-03-09 00:00:00

abstract：:Plant heat shock transcription factors (HSF) are highly complex. In this study, we identified an alfalfa HSF gene MsHSF1 that is composed of four exons and three introns in the encoding region. The intron1-exon2-intron2-exon3-intron3 as an intervening sequence was inserted at the conserved position that separates the ...

journal_title：Biochemical and biophysical research communications

authors： He ZS,Xie R,Zou HS,Wang YZ,Zhu JB,Yu GQ

更新日期：2007-12-28 00:00:00

abstract：:Saccharomyces cerevisiae antizyme (AZ) resembles mammalian AZ in its mode of synthesis by translational frameshifting and its ability to inhibit and facilitate the degradation of ornithine decarboxylase (ODC). Despite many studies on the interaction of AZ and ODC, the ODC:AZ complex has not been purified from any sour...

journal_title：Biochemical and biophysical research communications

authors： Chattopadhyay MK,Fernandez C,Sharma D,McPhie P,Masison DC

更新日期：2011-03-11 00:00:00

abstract：:The author found a sugar-containing 70 KDa factor in rat liver nuclei as described in the previous report (1), which repressed RNA chain initiation by all classes of rat liver RNA polymerases and specifically stimulated chromatin-dependent RNA chain elongation catalyzed by RNA polymerase II. In this communication, the...

journal_title：Biochemical and biophysical research communications

authors： Okai Y

更新日期：1984-11-30 00:00:00

abstract：:Previously we found a depression in the activity of hepatic xanthine dehydrogenase in rats fed clofibrate or di(2-ethylhexyl)phthalate. The present study further demonstrated that dietary addition of other peroxisome proliferators, including bezafibrate, dehydroepiandrosterone and perfluoro-n-octanoic acid also depres...

journal_title：Biochemical and biophysical research communications

authors： Satoh A,Sasago S,Takahashi S,Kato N

更新日期：1993-09-15 00:00:00

abstract：:Atherosclerosis is a chronic inflammation of the coronary arteries. Vascular smooth muscle cells (VSMCs) stimulated by cytokines and chemokines accelerate the inflammatory response and migrate to the injured endothelium during the progression of atherosclerosis. Activation of AMP activated protein kinase (AMPK), a key...

journal_title：Biochemical and biophysical research communications

authors： Kim SA,Choi HC

更新日期：2012-09-07 00:00:00

abstract：:Histone deacetylase inhibitors (HDACIs) are promising anti-tumor agents that selectively induce cell cycle arrest, differentiation and/or apoptosis of tumor cells. Fundamentally, HDACIs are proposed to function by activating the transcription of genes, including the potent cyclin dependent kinase inhibitor p21(WAF1). ...

journal_title：Biochemical and biophysical research communications

authors： Hirsch CL,Ellis DJ,Bonham K

更新日期：2010-11-26 00:00:00

abstract：:Thyroid cells transformed by the Kirsten-ras oncogene become tumorigenic in syngeneic animals. Their growth is no longer dependent on TSH but becomes dependent on serum. Combining morphological and biochemical evidence, we show that serum withdrawal induces apoptotic cell death in Kirsten and Harvey-ras transformed th...

journal_title：Biochemical and biophysical research communications

authors： di Jeso B,Ulianich L,Racioppi L,D'Armiento F,Feliciello A,Pacifico F,Consiglio E,Formisano S

更新日期：1995-09-25 00:00:00

abstract：:It is well established that lipid metabolism is controlled, in part, by circadian clocks. However, circadian clocks lose temporal precision with age and correlates with elevated incidence in dyslipidemia and metabolic syndrome in older adults. Because our lab has shown that lipoic acid (LA) improves lipid homeostasis ...

journal_title：Biochemical and biophysical research communications

authors： Keith D,Finlay L,Butler J,Gómez L,Smith E,Moreau R,Hagen T

更新日期：2014-07-18 00:00:00

abstract：:Methamphetamine induces several cardiac dysfunctions, which leads to arrhythmia, cardiac failure and sudden cardiac death. Although these cardiac alterations elicited by methamphetamine were thought to be due to an indirect action of methamphetamine, namely, an excessive catecholamine release from synaptic terminals, ...

journal_title：Biochemical and biophysical research communications

authors： Sugimoto K,Okamura K,Tanaka H,Takashima S,Ochi H,Yamamoto T,Matoba R

更新日期：2009-12-25 00:00:00

abstract：:In isolated rat pancreatic acini, protein expression of RhoA and Rho-associated kinase, ROCK-II, and the formation of immunocomplex of RhoA with ROCK-II were enhanced by CCK-8, carbachol, and the phorbol ester TPA. The ROCK-specific inhibitor, Y-27632, did not alter basal amylase secretion, whereas it potentiated CCK-...

journal_title：Biochemical and biophysical research communications

authors： Kusama K,Nozu F,Awai T,Tanaka S,Honma I,Tsunoda Y,Mitamura K

更新日期：2003-05-30 00:00:00

abstract：:Cultured bovine pulmonary artery endothelial cells contain a second peptidyl dipeptidase, distinct from angiotensin-converting enzyme, present in an inactive form associated with a non-dialyzable inhibitor. Partial purification by glycine affinity chromatography separates enzyme from inhibitor to yield a preparation w...

journal_title：Biochemical and biophysical research communications

authors： Lanzillo JJ,Dasarathy Y,Stevens J,Fanburg BL

更新日期：1986-01-29 00:00:00

abstract：:Until today, 14 isoforms of mammalian calpains have been identified, including calpain-5. The C. elegans calpain-5 homologue tra-3 is reported to be essential for necrotic neuronal cell death. In this study, we cloned and characterized rat calpain-5, which is highly homologous to human and mouse sequences. The nucleot...

journal_title：Biochemical and biophysical research communications

authors： Waghray A,Wang DS,McKinsey D,Hayes RL,Wang KK

更新日期：2004-11-05 00:00:00

abstract：:Protein kinase C phosphorylated both the 19/21-kDa regulatory light chains and heavy chains of bovine brain myosin. The major phosphorylation sites of the light chains were on their threonyl residues, while those for myosin light chain kinase were on their seryl residues. Whereas several non-muscle regular myosins hav...

journal_title：Biochemical and biophysical research communications

authors： Ikeda N,Yasuda S,Muguruma M,Matsumura S

更新日期：1990-06-29 00:00:00

abstract：:Polymorphic C-to-T change in the promoter region of DNA-methyltransferase-3B (DNMT3B) gene is associated with risk of several cancers. The aim of this study was to investigate the effect of DNMT3B promoter genetic variant on its transcriptional activity and to compare activity in several pancreatic cell lines. DNMT3B ...

journal_title：Biochemical and biophysical research communications

authors： Xiao Y,Word B,Hammons G,Lyn-Cook B

更新日期：2011-11-18 00:00:00