Interaction between phosphoinositide turnover system and cyclic AMP pathway for the secretion of pancreastatin and somatostatin from QGP-1N cells.

abstract：:Ciliogenesis is often impaired in some cancer cells, leading to acceleration of cancer phenotypes such as cell migration and proliferation. From the investigation of primary cilia of 16 gastric cancer cells (GCs), we found that GCs could be grouped into four primary cilia (PC)-positive GCs and 12 PC-negative GCs. The ...

journal_title：Biochemical and biophysical research communications

authors： Jung Y,Cho SM,Kim S,Cheong JH,Kwon HJ

更新日期：2021-02-05 00:00:00

abstract：:Adipose tissue-derived stem cells (ADSCs), which are easily harvested and show excellent pluripotency potential, have generated considerable interest in regenerative medicine. In this study, the differentiation of ADSCs was assessed after treatment with dental follicle cell conditioned medium (DFCCM) containing dentin...

journal_title：Biochemical and biophysical research communications

authors： Wen X,Nie X,Zhang L,Liu L,Deng M

更新日期：2011-06-10 00:00:00

abstract：:Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that mediates rapid degradation of transcripts bearing premature translation termination codons (PTCs) and thereby limits the expression of unproductively processed mRNAs and the synthesis of C-terminally truncated peptides. Both its importance as a means to...

journal_title：Biochemical and biophysical research communications

authors： Boelz S,Neu-Yilik G,Gehring NH,Hentze MW,Kulozik AE

更新日期：2006-10-13 00:00:00

abstract：:Human platelets labeled with [3H]arachidonic acid and permeabilized with saponin produced [3H]1,2-diacylglycerol (DG) by phospholipase C and released [3H]arachidonate by phospholipase A2, when activated with thrombin. Thrombin-induced arachidonate liberation was almost completely inhibited with pretreatment of pertuss...

journal_title：Biochemical and biophysical research communications

authors： Nakashima S,Hattori H,Shirato L,Takenaka A,Nozawa Y

更新日期：1987-11-13 00:00:00

abstract：:Administration of streptozotocin (STZ) induces destruction of β-cells and is widely used as an experimental animal model of type I diabetes. In neonatal rat, after low-doses of STZ-mediated destruction of β-cells, β-cells regeneration occurs and reversal of hyperglycemia was observed. However, in neonatal mice, β-cell...

journal_title：Biochemical and biophysical research communications

authors： Kataoka M,Kawamuro Y,Shiraki N,Miki R,Sakano D,Yoshida T,Yasukawa T,Kume K,Kume S

更新日期：2013-01-18 00:00:00

abstract：:Epidemiological data have shown that stress and other psychological factors might influence cancer onset and progression. However, to date, the mechanisms are not well understood. In the present study, we used chronic exposure to a scream as a novel form of sound stress to explore the influence of the chronic stress b...

journal_title：Biochemical and biophysical research communications

authors： Hou N,Zhang X,Zhao L,Zhao X,Li Z,Song T,Huang C

更新日期：2013-10-04 00:00:00

abstract：:Many studies have been reported that tripartite motif-containing (TRIM) proteins play important roles in various cellular processes and involved in many diseases. TRIM3, a member of TRIM family, has been proved that it plays important roles in various cancers. Nevertheless, its effects on cervical cancer reminded unkn...

journal_title：Biochemical and biophysical research communications

authors： Song Y,Guo Q,Gao S,Hua K

更新日期：2018-04-06 00:00:00

abstract：:Adrenomedullin (ADM) is a vasodilator peptide, first isolated from human pheochromocytoma. To explore the pathophysiological role of ADM in ischemic conditions, we investigated the effects of hypoxia on ADM production and ADM mRNA expression in a cultured human colorectal carcinoma cell line, DLD-1. Northern blot anal...

journal_title：Biochemical and biophysical research communications

authors： Nakayama M,Takahashi K,Murakami O,Shirato K,Shibahara S

更新日期：1998-02-13 00:00:00

abstract：:Treatment of newborn murine epidermal cells with phospholipase C results in the generation of a chemiluminescence response similar to that previously described for phorbol ester tumor promoters. Based on inhibitor studies, the oxidant, believed to be superoxide anion, is most likely generated from lipoxygenase metabol...

journal_title：Biochemical and biophysical research communications

authors： Fischer SM,Baldwin JK,Adams LM

更新日期：1985-09-30 00:00:00

abstract：:Oxygen has always been recognized as an essential element of many life forms, initially through its role as a terminal electron acceptor for the energy-generating pathways of oxidative phosphorylation. In 1955, Hayaishi et al. [Mechanism of the pyrocatechase reaction, J. Am. Chem. Soc. 77 (1955) 5450-5451] presented t...

journal_title：Biochemical and biophysical research communications

authors： Sligar SG,Makris TM,Denisov IG

更新日期：2005-12-09 00:00:00

abstract：:The origins and developmental regulation of cerebellar oligodendrocytes are largely unknown, although some hypotheses of embryonic origins have been suggested. Neural stem cells exist in the white matter of postnatal cerebellum, but it is unclear whether these neural stem cells generate oligodendrocytes at postnatal s...

journal_title：Biochemical and biophysical research communications

authors： Naruse M,Shibasaki K,Ishizaki Y

更新日期：2015-08-07 00:00:00

abstract：:The fate of [125I] lactoferrin after binding on its specific receptor on HT29-D4 cells, a clone of HT29 cells, was studied and compared with that of [125I]transferrin. Time courses of protein binding in relation with temperature clearly show that different mechanisms of ligand-transportation for the two glycoproteins ...

journal_title：Biochemical and biophysical research communications

authors： Roiron-Lagroux D,Figarella C

更新日期：1990-07-31 00:00:00

abstract：:Activation of the transcription factor NF-kappaB results in protection against apoptosis, and the chemotherapeutic agent 5-Fluorouracil (5-FU) exerts its cytotoxic effect through the induction of apoptosis. Thus, we examined whether 5-FU could induce apoptosis through the suppression of NF-kappaB activity. We found th...

journal_title：Biochemical and biophysical research communications

authors： Aota K,Azuma M,Yamashita T,Tamatani T,Motegi K,Ishimaru N,Hayashi Y,Sato M

更新日期：2000-07-14 00:00:00

abstract：:Very-long-chain acyl-CoA synthetases (VLCS) activate very-long-chain fatty acids (VLCFA) containing 22 or more carbons to their CoA derivatives. We cloned the human ortholog (hVLCS) of the gene encoding the rat liver enzyme (rVLCS). Both hVLCS and rVLCS contain 620 amino acids, are expressed primarily in liver and kid...

journal_title：Biochemical and biophysical research communications

authors： Steinberg SJ,Wang SJ,Kim DG,Mihalik SJ,Watkins PA

更新日期：1999-04-13 00:00:00

abstract：:A cDNA for murine transcription factor S-II (Hirashima et al., J. Biol. Chem (1988) 263, 3858-3863) was inserted into a silkworm baculovirus vector and expressed in Bm-N cells, a cell line of Bombyx mori maintained in the laboratory. Recombinant S-II was purified from virus-infected cell extracts to near homogeneity b...

journal_title：Biochemical and biophysical research communications

authors： Hirashima S,Horikoshi N,Sekimizu K,Natori S

更新日期：1989-05-15 00:00:00

abstract：:Polycystin-1 (PC1) is a membrane protein expressed in tubular epithelia of developing kidneys and in other ductal structures. Recent studies indicate this protein to be putatively important in regulating intracellular Ca(2+) levels in various cell types, but little evidence exists for kidney epithelial cells. Here we ...

journal_title：Biochemical and biophysical research communications

authors： Aguiari G,Campanella M,Manzati E,Pinton P,Banzi M,Moretti S,Piva R,Rizzuto R,del Senno L

更新日期：2003-02-14 00:00:00

abstract：:The role of recombination genes in the processing of DNA damaged by methlymethane sulfonate (MMS) was examined in an xth nth nfo strain of Escherichia coli K-12. Introduction of a recQ mutation did not increase the cell's sensitivity to MMS treatment. The presence of recF, recJ or recN mutation slightly increased the ...

journal_title：Biochemical and biophysical research communications

authors： Wang TC,Chang HY

更新日期：1991-10-31 00:00:00

abstract：:We isolated mouse CPP32/apopain cDNA, a mammalian homologue most closely related to Ced-3 in C. elegans, and examined the involvement of CPP32 in the apoptosis of nervous system during development. CPP32 is specifically expressed in the trigeminal (V) ganglia, facio-acoustic (VII-VIII) ganglion complex, and dorsal roo...

journal_title：Biochemical and biophysical research communications

authors： Mukasa T,Urase K,Momoi MY,Kimura I,Momoi T

更新日期：1997-02-24 00:00:00

abstract：:Investigations of the coenzyme specificity of N5-methyltetrahydrofolate-homocysteine methyltransferases of diverse biological origin revealed previously unrecognized differences between Escherichia coli methyltransferase and the corresponding enzymes of other species. Cyanocobalamin (CNCbl) actively supports methyltra...

journal_title：Biochemical and biophysical research communications

authors： Beck WS,Thorndike J

更新日期：1984-04-16 00:00:00

abstract：:Heavy water (D2O) has been used as a putative inhibitor of the plasma membrane H(+)-ATPase and the plasma membrane redox system. Concentrations above 50% D2O inhibited H+ secretion and the plasma membrane redox system of Zea mays L. roots. Inhibition of H+ secretion by vanadate was reduced in presence of D2O. The plas...

journal_title：Biochemical and biophysical research communications

authors： Döring O,Böttger M

更新日期：1992-01-31 00:00:00

abstract：:During adipocyte differentiation, CCAAT/enhancer-binding protein alpha (C/EBPalpha) functions as a pleiotropic transcriptional activator of numerous adipocyte genes. The promoter of the C/EBPalpha gene has an E-box upstream of C/EBP binding site. Deletion or mutation of the E-box decreases promoter activity, suggestin...

journal_title：Biochemical and biophysical research communications

authors： Kim JW,Monila H,Pandey A,Lane MD

更新日期：2007-03-09 00:00:00

abstract：:Discoidin domain receptor 2 (DDR2) is a receptor tyrosine kinase that is activated by fibrillar collagens. DDR2 regulates cell proliferation, cell adhesion, migration, and extracellular matrix remodeling. The decrement of endogenous DDR2 represses osteoblastic marker gene expression and osteogenic differentiation in m...

journal_title：Biochemical and biophysical research communications

authors： Kawai I,Hisaki T,Sugiura K,Naito K,Kano K

更新日期：2012-10-26 00:00:00

abstract：:We have isolated and sequenced a cDNA encoding the follicle stimulating hormone (FSH) receptor. The deduced amino acid sequence (678 residues) containing seven putative transmembrane segments which displays sequence similarity to G protein-coupled receptors. The receptor consists of 359 residue extracellular domain wh...

journal_title：Biochemical and biophysical research communications

authors： Minegishi T,Nakamura K,Takakura Y,Ibuki Y,Igarashi M,Minegish T corrected to Minegishi T

更新日期：1991-03-29 00:00:00

abstract：:The conditions used in some immunoblot procedures can fail to detect calmodulin, S100 proteins, and other proteins with similar physical properties. We describe here some of the basis of this difficulty, and provide an immunoblot protocol that allows the rapid and reproducible detection of calmodulin and S100 beta in ...

journal_title：Biochemical and biophysical research communications

authors： Van Eldik LJ,Wolchok SR

更新日期：1984-11-14 00:00:00

abstract：:To address the role of brain gangliosides in synaptic activity, the ceramide analogs, D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-PDMP) and its enantiomer, L-PDMP, were used to inhibit and stimulate ganglioside biosynthesis in cultured cortical neurons. Prolonged treatment with both PDMP isomers exhibi...

journal_title：Biochemical and biophysical research communications

authors： Inokuchi J,Mizutani A,Jimbo M,Usuki S,Yamagishi K,Mochizuki H,Muramoto K,Kobayashi K,Kuroda Y,Iwasaki K,Ohgami Y,Fujiwara M

更新日期：1997-08-28 00:00:00

abstract：:The microvesicles (MVs) in bovine posterior pituitaries contain the reserpine-sensitive vesicular monoamine transporter (Moriyama et al. (1995) J. Biol. Chem. 270, 11424-11429). An antibody against the N-terminal region of the monoamine transporter from bovine chromaffin granules recognized a polypeptide in the MVs wi...

journal_title：Biochemical and biophysical research communications

authors： Moriyama Y,Yamada H

更新日期：1996-04-25 00:00:00

abstract：:Iron is required in all organisms for crucial functions, as a number of proteins need iron for activity. Mutations of the genes encoding proteins involved in iron uptake, transport, and utilization result in various human disorders or animal models with very different clinical presentations and organ involvement. Howe...

journal_title：Biochemical and biophysical research communications

authors： Rötig A,Chantrel-Groussard K,Munnich A,Rustin P

更新日期：2001-03-02 00:00:00

abstract：:Deregulation of the expression of human papillomavirus (HPV) oncogenes E6 and E7 plays a pivotal role in cervical carcinogenesis because the E6 and E7 proteins neutralize p53 and Rb tumor suppressor pathways, respectively. In approximately 90% of all cervical carcinomas, HPVs are found to be integrated into the host g...

journal_title：Biochemical and biophysical research communications

authors： Lee K,Lee AY,Kwon YK,Kwon H

更新日期：2011-08-26 00:00:00

abstract：:The narrow leaf1 (nal1) mutant of rice (Oryza sativa L.) exhibits a narrow leaf phenotype. Previous studies have shown that NAL1 modulates leaf size by affecting vein patterning and cell division; however, the underlying mechanism remains unclear. Here, we report that the nal1 mutant shows reduced size of the leaf aba...

journal_title：Biochemical and biophysical research communications

authors： Lin L,Zhao Y,Liu F,Chen Q,Qi J

更新日期：2019-08-27 00:00:00

abstract：:Wet elastoidin spicules (fish fin rays) yield low-angle meridional X-ray diffraction patterns which resemble those from tendons. However, when the spicule dries the meridian splits into the arms of a diagonal cross (sometimes only one arm appears). Of the possible explanations we reject shearing of the axial arrangeme...

journal_title：Biochemical and biophysical research communications

authors： Hukins DW,Woodhead-Galloway J,Knight DP

更新日期：1976-12-20 00:00:00