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Functional inhibition of fatty acid binding protein 4 ameliorates impaired ciliogenesis in GCs.

Abstract：

:Ciliogenesis is often impaired in some cancer cells, leading to acceleration of cancer phenotypes such as cell migration and proliferation. From the investigation of primary cilia of 16 gastric cancer cells (GCs), we found that GCs could be grouped into four primary cilia (PC)-positive GCs and 12 PC-negative GCs. The proliferation of the PC-positive GCs was lower than that of PC-negative GCs. To explore the role of fatty acid binding protein 4 (FABP4), which is a known oncogenic factor, in ciliogenesis, FABP4 expression and function were inhibited by transfection of cells with short interfering RNA targeting FABP4 (siFABP4) or FABP4 inhibitor treatment. Notably, the proliferation and migration of the cilia-forming GCs was effectively suppressed by inhibition of FABP4. In addition, the primary cilia in GCs were restored by a factor greater than two, suggesting a negative role of FABP4 in ciliogenesis in these GCs and FABP4 as a potential anticancer target.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Jung Y,Cho SM,Kim S,Cheong JH,Kwon HJ

doi

10.1016/j.bbrc.2020.12.083

subject

Has Abstract

pub_date

2021-02-05 00:00:00

pages

28-33

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(20)32270-1

journal_volume

539

pub_type

杂志文章

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