Replacement of methionine as the axial ligand of Achromobacter cycloclastes cytochrome c554 at high pH values revealed by absorption, EPR and MCD spectroscopy.

abstract：:To determine whether the cytokine interleukin (IL)-6 induces heat shock protein (HSP) 72 gene expression in skeletal muscle, 18 healthy, young men had either a high dose of IL-6 (HiIL-6; n=6), low dose IL-6 (LoIL-6; n=6), or saline (CON; n=6) infused into one femoral artery for 3h. Muscle biopsies were obtained from t...

journal_title：Biochemical and biophysical research communications

authors： Febbraio MA,Steensberg A,Fischer CP,Keller C,Hiscock N,Pedersen BK

更新日期：2002-09-06 00:00:00

abstract：:A Ser48 phospholipase A2-homologue, ammodytin L, which is myotoxic in mammals and devoid of any phospholipase A2 activity, completely inhibits the specific binding of the neurotoxic phospholipase A2, ammodytoxin C, to fish presynaptic membranes from Torpedo marmorata electric organ. In cross-linking experiments, 125I-...

journal_title：Biochemical and biophysical research communications

authors： Pungercar J,Vucemilo N,Faure G,Bon C,Verheij HM,Gubensek F,Krizaj I

更新日期：1998-03-17 00:00:00

abstract：:A mutant of Photinus pyralis luciferase in which all four native cysteine residues are converted to serines retains about 10% of wild-type activity. This mutant should prove useful as a starting point for the introduction of biophysical probes of conformational changes associated with enzyme function. The activities o...

journal_title：Biochemical and biophysical research communications

authors： Kumita JR,Jain L,Safroneeva E,Woolley GA

更新日期：2000-01-07 00:00:00

abstract：:Aggregation of the high-affinity IgE receptor (FcepsilonRI) activates a tyrosine phosphorylation cascade needed for enhanced adhesion and degranulation events on mast cells. We previously identified the adaptor ADAP (otherwise known as FYB/SLAP) as a modulator of integrin-mediated adhesion of T-cells and mast cells. H...

journal_title：Biochemical and biophysical research communications

authors： Geng L,Rudd C

更新日期：2001-12-21 00:00:00

abstract：:The precise assemblage of several types of cardiac precursors controls heart organogenesis. The cardiac precursors show dynamic movement during early development and then form the complicated heart structure. However, cardiomyocyte movements inside the newly organized mammalian heart remain unclear. We previously esta...

journal_title：Biochemical and biophysical research communications

authors： Hashimoto H,Yuasa S,Tabata H,Tohyama S,Seki T,Egashira T,Hayashiji N,Hattori F,Kusumoto D,Kunitomi A,Takei M,Kashimura S,Yozu G,Shimojima M,Motoda C,Muraoka N,Nakajima K,Sakaue-Sawano A,Miyawaki A,Fukuda K

更新日期：2015-09-04 00:00:00

abstract：:We previously reported that tissue damage during brain infarction was mainly caused by inactivation of proteins by acrolein. This time, it was tested why brain infarction increases in parallel with aging. A mouse model of photochemically induced thrombosis (PIT) was studied using 2, 6, and 12 month-old female C57BL/6 ...

journal_title：Biochemical and biophysical research communications

authors： Uemura T,Watanabe K,Ishibashi M,Saiki R,Kuni K,Nishimura K,Toida T,Kashiwagi K,Igarashi K

更新日期：2016-04-29 00:00:00

abstract：:Tumor cell extravasation into the brain requires passage through the blood-brain barrier, which is a highly protected microvascular environment fortified with tight junction (TJ) proteins. TJ integrity can be regulated under physiological and pathophysiological conditions. There is evidence that exercise can modulate ...

journal_title：Biochemical and biophysical research communications

authors： Wolff G,Davidson SJ,Wrobel JK,Toborek M

更新日期：2015-08-07 00:00:00

abstract：:Anti-gene is a potent inhibitor of transcriptional promoter activity and subsequent gene expression. This property has been exploited to suppress the expression of a variety of oncogenes for regulating tumor proliferation or viral activities. In this paper, we describe a novel retroviral vector designed to express hum...

journal_title：Biochemical and biophysical research communications

authors： Okada T,Amanuma H,Okada Y,Obata M,Hayashi Y,Yamaguchi K,Yamashita J

更新日期：1997-11-07 00:00:00

abstract：:Preadipocyte factor-1 (pref-1) is specifically expressed in preadipocytes and acts as a gatekeeper of adipogenesis by maintaining the preadipocyte state and preventing adipocyte differentiation. We hypothesized that the breed differences of adipogenic capacity in cattle could be explained by the expression level of pr...

journal_title：Biochemical and biophysical research communications

authors： Yamada T,Higuchi M,Nakanishi N

更新日期：2014-03-07 00:00:00

abstract：:The nuclear lamina defines both structural and functional properties of the eukaryotic cell nucleus. Mutations in the LMNA gene, encoding A-type lamins, lead to a broad spectrum of diseases termed laminopathies. While different hypotheses have been postulated to explain disease development, there is still no unified v...

journal_title：Biochemical and biophysical research communications

authors： Sieprath T,Darwiche R,De Vos WH

更新日期：2012-05-18 00:00:00

abstract：:A method to prepare amyloid-like fibrils functionalized with magnetic nanoparticles has been developed. The amyloid-like fibrils are prepared in a two step procedure, where insulin and magnetic nanoparticles are mixed simply by grinding in the solid state, resulting in a water soluble hybrid material. When the hybrid ...

journal_title：Biochemical and biophysical research communications

authors： Andersson BV,Skoglund C,Uvdal K,Solin N

更新日期：2012-03-23 00:00:00

abstract：:Amylin, an islet amyloid peptide secreted by the pancreatic beta cell, has been proposed as a humoral regulator of islet insulin secretion. Four separate preparations of amylin were tested for effects on hormone secretion in both freshly isolated and cultured rat islets and in HIT-T15, hamster insulinoma cells. With a...

journal_title：Biochemical and biophysical research communications

authors： Broderick CL,Brooke GS,DiMarchi RD,Gold G

更新日期：1991-06-28 00:00:00

abstract：:Hepatitis C virus (HCV) causes chronic hepatitis C (CH-C) and is epidemiologically linked with the occurrence of hepatocellular carcinoma (HCC). To elucidate the comprehensive gene expression profiles of CH-C and HCC, serial analysis of gene expression (SAGE) libraries were made from CH-C and HCC tissues of a patient,...

journal_title：Biochemical and biophysical research communications

authors： Yamashita T,Kaneko S,Hashimoto S,Sato T,Nagai S,Toyoda N,Suzuki T,Kobayashi K,Matsushima K

更新日期：2001-03-30 00:00:00

abstract：:The ability of the rat brain to activate the phosphorothionate insecticide parathion to its potent anticholinesterase metabolite paraoxon in situ was observed by ligating the posterior portion of the circulatory system and thus removing the liver from the circulation. Under these conditions no acetylcholinesterase inh...

journal_title：Biochemical and biophysical research communications

authors： Chambers JE,Munson JR,Chambers HW

更新日期：1989-11-30 00:00:00

abstract：:Three metallo forms of peptide deformylase (PDF, EC 3.5.1.31) of Escherichia coli were prepared and crystallized (space group C2, diffraction limit 1.9 A) for initiating the X-ray structure determination of the metal center in correlation with the catalytic functionality of this enzyme. The native Fe2+ containing enzy...

journal_title：Biochemical and biophysical research communications

authors： Groche D,Becker A,Schlichting I,Kabsch W,Schultz S,Wagner AF

更新日期：1998-05-19 00:00:00

abstract：:Protein kinase C (PKC) fulfills a central role in the decision of cell fate in keratinocytes. Both PKC delta and PKC eta induce growth inhibition and differentiation of normal human keratinocytes (NHK). Here we show that PKC delta and PKC eta play opposite roles in UVB-induced apoptosis in NHK. PKC delta enhanced UVB-...

journal_title：Biochemical and biophysical research communications

authors： Matsumura M,Tanaka N,Kuroki T,Ichihashi M,Ohba M

更新日期：2003-03-28 00:00:00

abstract：:Nicastrin is a recently discovered protein interacting with presenilins and the beta-amyloid precursor protein, the proteins playing key roles in Alzheimer's disease and which, when mutated, appear responsible for early-onset familial forms of Alzheimer's disease. Nicastrin was reported to modulate beta-amyloid produc...

journal_title：Biochemical and biophysical research communications

authors： Fergani A,Yu G,St George-Hyslop P,Checler F

更新日期：2001-12-07 00:00:00

abstract：:TWIST1, a basic helix-loop-helix transcription factor, plays critical roles in embryo development, cancer metastasis and mesenchymal progenitor differentiation. Little is known about transcriptional regulation of TWIST1 expression. Here we identified DNA sequences responsible for TWIST1 expression in mesenchymal linea...

journal_title：Biochemical and biophysical research communications

authors： Ohkuma M,Funato N,Higashihori N,Murakami M,Ohyama K,Nakamura M

更新日期：2007-01-26 00:00:00

abstract：:Neuromedin B and neuromedin C are the novel mammalian bombesin-like peptides isolated from porcine spinal cord. We have developed highly specific and sensitive radioimmunoassays for neuromedin B and neuromedin C, and determined their regional distribution in rat central nervous system. Prior to measurements of the tis...

journal_title：Biochemical and biophysical research communications

authors： Minamino N,Kangawa K,Matsuo H

更新日期：1984-11-14 00:00:00

abstract：:In Alzheimer's disease a small fragment of the amyloid protein precursor (APP), called beta 4, is a characteristic component of senile plaques in brains of affected patients. Efforts to intervene in Alzheimer's disease include approaches by which APP levels can be decreased in brain. The study described here demonstra...

journal_title：Biochemical and biophysical research communications

authors： Yang F,Jansen L,Friedrichs WE,Buchanan JM,Bowman BH

更新日期：1993-03-31 00:00:00

abstract：:This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of authors. The Journal received an expression of concern from a reader, which noted that: “The problem is that there is no IL-26 gene in t...

journal_title：Biochemical and biophysical research communications

authors： Bao J,Lv Z,Wang S

更新日期：2018-05-23 00:00:00

abstract：:Several groups have demonstrated that induction of heme-oxygenase-1 (HO-1) could protect the myocardium against ischemic events; however, heme accumulation could lead to toxicity. The aim of the present study was to investigate the role of autophagy in heme toxicity. H9c2 cardiomyoblast cells were treated with differe...

journal_title：Biochemical and biophysical research communications

authors： Gyongyosi A,Szoke K,Fenyvesi F,Fejes Z,Debreceni IB,Nagy B Jr,Tosaki A,Lekli I

更新日期：2019-04-16 00:00:00

abstract：:Tubby domain superfamily protein (TUSP) is a distant member of the Tubby-like protein (TULP) family. Although other TULPs play important roles in sensation, metabolism, and development, the molecular functions of TUSP are completely unknown. Here, we explore the function of TUSP in the Drosophila nervous system where ...

journal_title：Biochemical and biophysical research communications

authors： Yoon EJ,Jeong YT,Lee JE,Moon SJ,Kim CH

更新日期：2017-01-22 00:00:00

abstract：:After screening the data base of the Berkeley Drosophila Genome Project with a sequence coding for the transmembrane region of a G protein-coupled receptor, we found that Drosophila might contain a gene coding for a receptor that is structurally related to the Gonadotropin-Releasing Hormone (GnRH) receptors from verte...

journal_title：Biochemical and biophysical research communications

authors： Hauser F,Søndergaard L,Grimmelikhuijzen CJ

更新日期：1998-08-28 00:00:00

abstract：:A subclone termed as HSG-S8 was previously isolated from human salivary adenocarcinoma cell line, HSG, and proliferated in a serum-free culture. When HSG-S8 and parental HSG cells were transplanted into nude mice i.m. or s.c., both cells reproducibly induced adenocarcinoma. Furthermore, injection of HSG-S8 consistentl...

journal_title：Biochemical and biophysical research communications

authors： Hatakeyama S,Ohara-Nemoto Y,Kyakumoto S,Satoh M

更新日期：1993-02-15 00:00:00

abstract：:We have found that atrial natriuretic factor (ANF) has a profound effect on testicular cells in altering intracellular cyclic nucleotide levels as well as progesterone secretion. Using clonal cultured Leydig tumor cells we found that 1 X 10(-8)M ANF caused a two thousand-fold elevation in the accumulation of cellular ...

journal_title：Biochemical and biophysical research communications

authors： Pandey KN,Kovacs WJ,Inagami T

更新日期：1985-12-17 00:00:00

abstract：:The intra-hepatic population of liver progenitor cells expands during liver injury when hepatocyte proliferation is inhibited. These cells can be purified by density gradient centrifugation and cultured. Separated by size only this population contains small cells of hematopoietic, epithelial and endothelial lineages a...

journal_title：Biochemical and biophysical research communications

authors： Clayton E,Forbes SJ

更新日期：2009-04-17 00:00:00

abstract：:Addition of 5% hexadecane to the diet of rats increased fecal excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) from 14 to 39% of an LD50 dose (60 micrograms/kg) during 10 days after dosing. This enhanced elimination did not result in reduced toxicity. On the contrary, the treatment has increased mortality from ...

journal_title：Biochemical and biophysical research communications

authors： Rozman K

更新日期：1984-12-28 00:00:00

abstract：:It has been shown that MDM2 inhibits the transcriptional and pro-apoptotic activities of p73 but does not promote its proteasomal degradation. In this study, we found that MDM2 indirectly induces the degradation of p73 through the interaction with Itch in HeLa cells. During adriamycin (ADR)-mediated apoptosis, p53 and...

journal_title：Biochemical and biophysical research communications

authors： Kubo N,Okoshi R,Nakashima K,Shimozato O,Nakagawara A,Ozaki T

更新日期：2010-12-17 00:00:00

abstract：:We determined the existence and role of beta(2)-adrenergic receptor in cultured BAECs through the effect of a beta-blocker having NO releasing action; 3,4-dihydro-8(2-hydroxy-3-isopropylamino)-propoxy-3-nitroxy-2H-1-benzopyran; nipradilol on eNOS and eNOS regulatory protein caveolin-1. beta(2) receptor exists in BAECs...

journal_title：Biochemical and biophysical research communications

authors： Jayachandran M,Hayashi T,Sumi D,Thakur NK,Kano H,Ignarro LJ,Iguchi A

更新日期：2001-01-26 00:00:00