Abstract:
:Amylin, an islet amyloid peptide secreted by the pancreatic beta cell, has been proposed as a humoral regulator of islet insulin secretion. Four separate preparations of amylin were tested for effects on hormone secretion in both freshly isolated and cultured rat islets and in HIT-T15, hamster insulinoma cells. With all three experimental models, exposure to human amylin acid and human and rat amylin at concentrations as high as 100 nM had no significant effect on rates of insulin or glucagon secretion. These observations suggest that amylin, even at concentrations appreciably higher than those measured in peripheral plasma, is not a significant humoral regulator of islet hormone secretion.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Broderick CL,Brooke GS,DiMarchi RD,Gold Gdoi
10.1016/0006-291x(91)90628-ksubject
Has Abstractpub_date
1991-06-28 00:00:00pages
932-8issue
3eissn
0006-291Xissn
1090-2104pii
0006-291X(91)90628-Kjournal_volume
177pub_type
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journal_title:Biochemical and biophysical research communications
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