当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Nonhistone protein HMG1 removes the transcriptional block caused by left-handed Z-form segment in a supercoiled DNA.

Nonhistone protein HMG1 removes the transcriptional block caused by left-handed Z-form segment in a supercoiled DNA.

Abstract：

:The effect of HMG1 on the transcriptional block caused by left-handed Z-form in a highly negatively supercoiled DNA was examined using a supercoiled plasmid containing a (CG)10 sequence downstream of promoters. The transcription by E. coli RNA polymerase was blocked at the boundary of alternating CG sequence in the Z-form. In the presence of HMG1, RNA polymerase could transcribe through the CG sequence resulting in the chain elongation of transcripts. The addition of HMG1 allowed the stalled RNA polymerase at the CG block to resume transcription. These suggest that HMG1 may remove the Z-block by flipping it back into the B-form.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Waga S,Mizuno S,Yoshida M

doi

10.1016/s0006-291x(88)81227-0

subject

Has Abstract

pub_date

1988-05-31 00:00:00

pages

334-9

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(88)81227-0

journal_volume

153

pub_type

杂志文章

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