Studies of human and rat blood under oxidative stress: changes in plasma thiol level, antioxidant enzyme activity, protein carbonyl content, and fluidity of erythrocyte membrane.

abstract：:Satellite cells that reside on the myofibre surface are crucial for the muscle homeostasis and regeneration. Aging goes along with a less effective regeneration of skeletal muscle tissue mainly due to the decreased myogenic capability of satellite cells. This phenomenon impedes proper maintenance and contributes to th...

journal_title：Biochemical and biophysical research communications

authors： Di Filippo ES,Mancinelli R,Pietrangelo T,La Rovere RM,Quattrocelli M,Sampaolesi M,Fulle S

更新日期：2016-04-29 00:00:00

abstract：:Matrix metalloproteinases (MMP-2 and -9) play an important role in the tumor metastasis through cleavage of proinflammatory cytokines. Violacein a small molecule produced by Chromobacterium violaceum and has been implicated with anti-cancer effects. In this study we investigated the molecular basis of violacein mediat...

journal_title：Biochemical and biophysical research communications

authors： Platt D,Amara S,Mehta T,Vercuyssee K,Myles EL,Johnson T,Tiriveedhi V

更新日期：2014-12-05 00:00:00

abstract：:Chikungunya is a severe disease that results from infection with the chikungunya virus (CHIKV), an arbovirus. Thus, we (1) explored a new approach to combining previously researched drugs that have shown the potential to inhibit CHIKV infection; and (2) demonstrated the antiviral effects of (-)-Epigallocatechin-3-gall...

journal_title：Biochemical and biophysical research communications

authors： Lu JW,Hsieh PS,Lin CC,Hu MK,Huang SM,Wang YM,Liang CY,Gong Z,Ho YJ

更新日期：2017-09-23 00:00:00

abstract：:Some mutations in mitochondrial DNA (mtDNA) causing a number of neuromuscular diseases are suggested to arise spontaneously during the life of an individual. To substantiate the extent and the rate of these somatic mutations, mtDNA specimens from post-mortem human heart muscles of subjects in differing age groups were...

journal_title：Biochemical and biophysical research communications

authors： Hayakawa M,Hattori K,Sugiyama S,Ozawa T

更新日期：1992-12-15 00:00:00

abstract：:Systemic sclerosis (SSc) or scleroderma is a generalized disorder of connective tissue. The etiology is poorly understood; however, both genetic and environmental factors have been implicated. To investigate the disease-susceptible gene for SSc, we examined the association of the disease with a gene (COL1A2) for type ...

journal_title：Biochemical and biophysical research communications

authors： Hata R,Akai J,Kimura A,Ishikawa O,Kuwana M,Shinkai H

更新日期：2000-05-27 00:00:00

abstract：:Human bladder carcinoma cell line EJ-1 secreted a protein of 30 kDa as a major component. This protein was purified from the serum-free conditioned medium of EJ-1. Its N-terminal amino acid sequence was identical to that of fibroblast-derived endothelial cell growth factor (f-ECGF), but there were differences in their...

journal_title：Biochemical and biophysical research communications

authors： Akaogi K,Okabe Y,Funahashi K,Yoshitake Y,Nishikawa K,Yasumitsu H,Umeda M,Miyazaki K

更新日期：1994-02-15 00:00:00

abstract：:Calcium/calmodulin-dependent protein kinase II (CaM KII) is thought to be involved in the majority of the neuronal functions mediated by intracellular free Ca(2+), and has been implicated in long-term potentiation, learning, and memory. In this work, we have examined in detail the RNA expression pattern for the Drosop...

journal_title：Biochemical and biophysical research communications

authors： Rachidi M,Lopes C,Takamatsu Y,Ohsako S,Benichou JC,Delabar JM

更新日期：1999-07-14 00:00:00

abstract：:We have investigated the angiogenic effects of basic fibroblast growth factor following its implantation in slow release beads under the kidney capsule. The presence of basic fibroblast growth factor in the subcapsular space induced a marked angiogenic response maximal at 1 microgram dose per kidney. Histological exam...

journal_title：Biochemical and biophysical research communications

authors： Hayek A,Culler FL,Beattie GM,Lopez AD,Cuevas P,Baird A

更新日期：1987-09-15 00:00:00

abstract：:Co-transcriptional RNA proofreading by RNA polymerase (RNAP) is essential for accurate mRNA synthesis and reactivation of stalled transcription complexes, which can otherwise compromise genome integrity. RNAP from the stress-resistant bacterium Deinococcus radiodurans exhibits high levels of RNA cleavage in comparison...

journal_title：Biochemical and biophysical research communications

authors： Esyunina D,Kulbachinskiy A

更新日期：2019-01-29 00:00:00

abstract：:AMP-activated protein kinase (AMPK) is a master metabolic regulator, and is an important target for drug development against diabetes, obesity, and other diseases. AMPK is a hetero-trimeric enzyme, with a catalytic (alpha) subunit, and two regulatory (beta and gamma) subunits. Here we report the crystal structure at 2...

journal_title：Biochemical and biophysical research communications

authors： Rudolph MJ,Amodeo GA,Bai Y,Tong L

更新日期：2005-12-02 00:00:00

abstract：:The synthesis of sufficient amounts of oligosaccharides is the bottleneck for the study of their biological function and their possible use as drug. As an alternative for chemical synthesis, we propose to use Escherichia coli as a "living factory." We have addressed the production of the Galp alpha(1-3)Galp beta(1-4)G...

journal_title：Biochemical and biophysical research communications

authors： Bettler E,Imberty A,Priem B,Chazalet V,Heyraud A,Joziasse DH,Geremia RA

更新日期：2003-03-14 00:00:00

abstract：:A protein which inhibits the prophenoloxidase----phenoloxidase (EC 1.14.18.1) proteolytic activation in hemocyte extracts of Locusta migratoria was isolated from the plasma of the same insect and partially characterized. It shows a molecular weight of 14,000, an inhibiting activity toward the cascade system in the ins...

journal_title：Biochemical and biophysical research communications

authors： Brehélin M,Boigegrain RA,Drif L,Coletti-Previero MA

更新日期：1991-09-16 00:00:00

abstract：:Hypothesis of non-enzymatic recognition of primordial tRNA and mRNA precursors is experimentally approached. DNA hairpins containing a different number of deoxyguanosine residues in the loop are analyzed for their binding ability to a chemically fixed single-strand of oligo(dC). In presence of small Mg2+ concentration...

journal_title：Biochemical and biophysical research communications

authors： Baumann U,Frank R,Blöcker H

更新日期：1988-12-30 00:00:00

abstract：:Neuromedin K and neuromedin L are novel mammalian tachykinins isolated from porcine spinal cord. We have developed a highly sensitive radioimmunoassay for neuromedin K. Since the radioimmunoassay for neuromedin K has significant crossreactivity with neuromedin L and substance P, we can simultaneously determine the tis...

journal_title：Biochemical and biophysical research communications

authors： Minamino N,Masuda H,Kangawa K,Matsuo H

更新日期：1984-11-14 00:00:00

abstract：:DNA topoisomerase type I and II activities were determined by serial dilution in nuclear extracts from control and ataxia-telangiectasia lymphoblastoid cells. Topoisomerase I activity, assayed by relaxation of supercoiled plasmid DNA, was found to be approximately the same in both cell types. In order to remove interf...

journal_title：Biochemical and biophysical research communications

authors： Mohamed R,Pal Singh S,Kumar S,Lavin MF

更新日期：1987-11-30 00:00:00

abstract：:Lack or dysfunction of insulin producing β cells results in the development of type 1 and type 2 diabetes mellitus, respectively. Insulin secretion is controlled by metabolic stimuli (glucose, fatty acids), but also by monoamine neurotransmitters, like dopamine, serotonin, and norepinephrine. Intracellular monoamine l...

journal_title：Biochemical and biophysical research communications

authors： Ganic E,Johansson JK,Bennet H,Fex M,Artner I

更新日期：2015-12-25 00:00:00

abstract：:Spermine and spermidine are present in rat liver mitochondria at the concentrations of 3.5 and 1.8 nanomoles/mg protein, respectively. Addition of 50 microM Ca2+ and 1 mM Pi to respiring mitochondria induces, concomitantly with mitochondrial swelling and Mg2+ efflux, a consistent release of polyamines, which is either...

journal_title：Biochemical and biophysical research communications

authors： Tassani V,Campagnolo M,Toninello A,Siliprandi D

更新日期：1996-09-24 00:00:00

abstract：:The non-receptor tyrosine kinases c-Src and focal adhesion kinase (Fak) mediate signal transduction pathways that regulate cell proliferation, survival, invasion, and metastasis. Here, we investigated whether c-Src and Fak are activated during progression of hormone-dependent breast cancer. Maximally active c-Src was ...

journal_title：Biochemical and biophysical research communications

authors： Planas-Silva MD,Bruggeman RD,Grenko RT,Stanley Smith J

更新日期：2006-03-03 00:00:00

abstract：:The addition of low concentrations of phorbol 12-myristate 13-acetate to rabbit neutrophils induces cell aggregation, degranulation, increased oxygen consumption and an increase in the amount of actin associated with the cytoskeleton without a rise in the level of intracellular free calcium as measured using the fluor...

journal_title：Biochemical and biophysical research communications

authors： Sha'afi RI,White JR,Molski TF,Shefcyk J,Volpi M,Naccache PH,Feinstein MB

更新日期：1983-07-29 00:00:00

abstract：:Hedgehog (Hh) signaling plays key roles in animal development and tissue homeostasis. Binding of the secreted ligand to its Ptch1 receptor triggers Hh signaling through distinct canonical or noncanonical signaling pathways. Canonical Hh signaling leads to the activation of Gli transcription factors to induce Hh target...

journal_title：Biochemical and biophysical research communications

authors： Lee H,Ko HW

更新日期：2016-11-25 00:00:00

abstract：:The ability of cholecystokinin (CCK) to elevate intracellular Ca2+ levels in small cell lung cancer cells was investigated using the fluorescent Ca2+ indicator Fura 2. CCK-8 elevated the cytosolic Ca2+ levels in cell line NCI-H345 in a dose dependent manner. Nanomolar concentration of CCK-8 elevated cytosolic Ca2+ lev...

journal_title：Biochemical and biophysical research communications

authors： Staley J,Fiskum G,Moody TW

更新日期：1989-08-30 00:00:00

abstract：:Histamine H3 receptor (H3R), one of G protein-coupled receptors (GPCRs), has been known to regulate neurotransmitter release negatively in central and peripheral nervous systems. Recently, a variety of intracellular proteins have been identified to interact with carboxy (C)-termini of GPCRs, and control their intracel...

journal_title：Biochemical and biophysical research communications

authors： Maeda K,Haraguchi M,Kuramasu A,Sato T,Ariake K,Sakagami H,Kondo H,Yanai K,Fukunaga K,Yanagisawa T,Sukegawa J

更新日期：2008-05-02 00:00:00

abstract：:The cAMP response element binding protein (CREB) is expressed at constitutively low levels in most cell types, and the CREB promoter possesses features that are typical of house-keeping genes. Since the CREB promoter also contains sequences which can mediate cAMP responsiveness in transfection experiments, it has been...

journal_title：Biochemical and biophysical research communications

authors： Crosson SM,Davies GF,Roesler WJ

更新日期：1996-10-23 00:00:00

abstract：:Alzheimer's disease is a neurodegenerative disorder characterised by extracellular accumulation of the Abeta peptide, derived from the amyloid precursor protein (APP). The function of APP as a cell surface receptor was examined by ligand-mimicking using an antibody against the APP extracellular domain. Alterations in ...

journal_title：Biochemical and biophysical research communications

authors： Nilsson T,Malkiewicz K,Gabrielsson M,Folkesson R,Winblad B,Benedikz E

更新日期：2006-03-24 00:00:00

abstract：:Structural determinants of L-[(3)H]nicotine binding to synthetic peptides comprising residues 188-207 of nicotinic acetylcholine receptor alpha subunits were invesitigated by equilibrium binding analysis. Two binding components were detected, one of low affinity (K(d) approximately 1.5 microM) that did not differ sign...

journal_title：Biochemical and biophysical research communications

authors： Lentz TL

更新日期：2000-02-16 00:00:00

abstract：:Rat intoxication with a single dose of the hepatotoxin carbon tetrachloride induces a significant modification of liver protein kinase C total activity which depends on the degree of the intrahepatocyte oxidative unbalance provoked by various concentrations of the haloalkane. Low carbon tetrachloride amounts stimulate...

journal_title：Biochemical and biophysical research communications

authors： Pronzato MA,Domenicotti C,Rosso E,Bellocchio A,Patrone M,Marinari UM,Melloni E,Poli G

更新日期：1993-07-30 00:00:00

abstract：:Helicobacter pylori releases VacA both as free-soluble and as outer membrane vesicle (OMV)-associated toxin. In this study, we investigated the amount of VacA released in each of the two forms and the role of each form in VacA-induced cell vacuolation in vitro. We found that: (1) free-soluble toxin accounted for about...

journal_title：Biochemical and biophysical research communications

authors： Ricci V,Chiozzi V,Necchi V,Oldani A,Romano M,Solcia E,Ventura U

更新日期：2005-11-11 00:00:00

abstract：:The importance of circular RNAs (circRNAs) in human cancers has gradually been acknowledged. In hepatocellular carcinoma (HCC), several circRNAs have been reported to regulate tumor growth and metastasis. However, the role of hsa_circ_0000673 in HCC remains largely unknown. In this study, we found that hsa_circ_000067...

journal_title：Biochemical and biophysical research communications

authors： Jiang W,Wen D,Gong L,Wang Y,Liu Z,Yin F

更新日期：2018-06-02 00:00:00

abstract：:The relation between platelet-derived growth factor (PDGF)-induced smooth muscle cell migration, measured in Boyden chambers, and cellular arachidonic acid cascade was studied by using rat aortic smooth muscle cells. Partially purified PDGF stimulated cell migration significantly at a concentration of 1.33-133.0 micro...

journal_title：Biochemical and biophysical research communications

authors： Nakao J,Ito H,Chang WC,Koshihara Y,Murota S

更新日期：1983-05-16 00:00:00

abstract：:Fibronectin, von Willebrand factor, and fibrinogen each bind to the glycoprotein IIb-IIIa complex on activated platelets via an arg-gly-asp-ser (RGDS) sequence present within the adhesive proteins. Both the IIb and IIIa polypeptides of the IIb-IIIa complex on thrombin activated platelets are specifically and extensive...

journal_title：Biochemical and biophysical research communications

authors： Santoro SA,Lawing WJ Jr

更新日期：1989-04-14 00:00:00