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Synergistic effects of combination treatment using EGCG and suramin against the chikungunya virus.

Abstract：

:Chikungunya is a severe disease that results from infection with the chikungunya virus (CHIKV), an arbovirus. Thus, we (1) explored a new approach to combining previously researched drugs that have shown the potential to inhibit CHIKV infection; and (2) demonstrated the antiviral effects of (-)-Epigallocatechin-3-gallate (EGCG) and the underlying mechanisms. Specifically, we used U2OS cells infected with CHIVK to assess the synergistic antiviral activities of EGCG and suramin. EGCG presented the ability to inhibit the viral RNA, progeny yield, and cytopathic effect (CPE) of CHIKV and also demonstrated the ability to protect against virus entry, replication, and release. Moreover, the results confirmed that EGCG and suramin can have synergistic effects against CHIKV strain S27 infection and two other clinical isolates of CHIKV. Our findings suggest that treatment with a combination of EGCG and suramin could provide a basis for the development of novel stretages against CHIKV infection.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Lu JW,Hsieh PS,Lin CC,Hu MK,Huang SM,Wang YM,Liang CY,Gong Z,Ho YJ

doi

10.1016/j.bbrc.2017.07.157

subject

Has Abstract

pub_date

2017-09-23 00:00:00

pages

595-602

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(17)31524-3

journal_volume

491

pub_type

杂志文章

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