Modification of MDMX by sumoylation.

abstract：:The effect of Ro 28-2653, a synthetic matrix metalloproteinase (MMP) inhibitor, on adipose tissue development was studied in mice kept on a high fat diet (HFD). Five-week-old male wild-type (C57Bl/6J) mice were fed the HFD (42% kcal as fat, 20.1 kJ/g) and received daily p.o. instillations of inhibitor (30 mg/kg) or ve...

journal_title：Biochemical and biophysical research communications

authors： Demeulemeester D,Collen D,Lijnen HR

更新日期：2005-04-01 00:00:00

abstract：:The isolation and characterization of cofactor-independent phosphoglycerate mutase gene from maize (Zea mays) is here reported. This gene sequence constitutes the first described from this enzyme. The gene spans 5.4 kilo base pairs and has nine exons in the translated region. Canonical TATA and CCAAT and Sp1-like boxe...

journal_title：Biochemical and biophysical research communications

authors： Pérez de la Ossa P,Graña X,Ruiz-Lozano P,Climent F

更新日期：1994-09-15 00:00:00

abstract：:Leber's hereditary optic neuropathy (LHON) has been associated with "primary" and "secondary" mtDNA missense point mutations, and a synergistic role has been proposed for secondary mutations. No previous study has investigated the effects of LHON primary or primary plus secondary mutations on the respiratory competenc...

journal_title：Biochemical and biophysical research communications

authors： Vergani L,Martinuzzi A,Carelli V,Cortelli P,Montagna P,Schievano G,Carrozzo R,Angelini C,Lugaresi E

更新日期：1995-05-25 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPAR-gamma) decreases the growth of certain cancer cells. In the present study, we found that six different human pancreatic cancer cell lines (AsPC-1, BxPC-3, Capan-2, HPAF-II, MIA PaCa-2, and PANC-1) expressed PPAR-gamma m-RNA and synthesized the protein. The endogen...

journal_title：Biochemical and biophysical research communications

authors： Eibl G,Wente MN,Reber HA,Hines OJ

更新日期：2001-09-21 00:00:00

abstract：:Bovine conglutinin is a Ca(2+)-dependent serum lectin specific for N-acetylglucosamine. In the present study, we report the exon-intron organization and the sequence of 5'-regulatory region of the conglutinin gene. The coding region of conglutinin mRNA, which encoded the signal peptide and the sequence of the mature p...

journal_title：Biochemical and biophysical research communications

authors： Kawasaki N,Itoh N,Kawasaki T

更新日期：1994-01-28 00:00:00

abstract：:Three dnaK gene homologs have been cloned and sequenced from cyanobacterium Synechococcus sp. PCC7942 using a set of primers designed from two conserved regions of known dnaK genes. This is the first example of triple genes for dnaK from prokaryotic cells. These three genes were derived from different loci of the chro...

journal_title：Biochemical and biophysical research communications

authors： Nimura K,Yoshikawa H,Takahashi H

更新日期：1994-05-30 00:00:00

abstract：BACKGROUND:The prognosis of patients after acute kidney injury (AKI) is poor and treatment is limited. AKI is mainly caused by renal ischemia/reperfusion injury (IRI). During the extension phase of IRI, endothelial damage may participate in ischemia and inflammation. Endothelin-1 (ET-1) which is mostly secreted by endo...

journal_title：Biochemical and biophysical research communications

authors： Arfian N,Emoto N,Vignon-Zellweger N,Nakayama K,Yagi K,Hirata K

更新日期：2012-08-24 00:00:00

abstract：:Regarding the molecular mechanism of dynamin in receptor-mediated endocytosis, GTPase activity of dynamin has been thought to have a critical role in endocytic vesicle internalization. However, a recent report suggested that GTP-binding to dynamin itself activates the dynamin to recruit molecular machinery necessary f...

journal_title：Biochemical and biophysical research communications

authors： Jeong MJ,Yoo J,Lee SS,Lee KI,Cho A,Kwon BM,Moon MJ,Park YM,Han MY

更新日期：2001-04-27 00:00:00

abstract：:DNp73 is a transactivation domain (TAD)-truncated form of p73. The ability of DNp73alpha to regulate gene expression was examined using reporter assays with luciferase gene constructs. Among various promoter-regulated reporter genes tested, heat shock factor (HSF)-responsive gene expression was selectively activated b...

journal_title：Biochemical and biophysical research communications

authors： Tanaka Y,Kameoka M,Itaya A,Ota K,Yoshihara K

更新日期：2004-05-07 00:00:00

abstract：:The biological significance of isoprenoid compounds such as ubiquinones, prenols and sterols have been well established. The presence and biological function of the two quinones Q6 and Q8 in the cattle filarial parasite Setaria digitata have already been reported. Inhibition of the function of quinone was already show...

journal_title：Biochemical and biophysical research communications

authors： Kumari GA,Santhamma KR,Raj RK

更新日期：1994-11-30 00:00:00

abstract：:Poly (ADP-ribose) polymerase 1 (PARP1) is an ADP- ribosylation enzyme and plays important roles in a variety of cellular processes, including DNA damage response and tumor development. However, the post-transcriptional regulation of PARP1 remains largely unknown. In this study, we identified that the mRNA of PARP1 is ...

journal_title：Biochemical and biophysical research communications

authors： Song D,Huang H,Wang J,Zhao Y,Hu X,He F,Yu L,Wu J

更新日期：2017-06-17 00:00:00

abstract：:Caspase-9 is one caspase upstream of caspase-3 and its activation is stimulated by Apaf-1/cytochrome c and inhibited by Akt signals. BAD phosphorylation by Akt is an essential step for growth factor-mediated inhibition of caspase activation. Recently, it was shown that human caspase-9 is phosphorylated by Akt and that...

journal_title：Biochemical and biophysical research communications

authors： Fujita E,Jinbo A,Matuzaki H,Konishi H,Kikkawa U,Momoi T

更新日期：1999-10-22 00:00:00

abstract：:Using a subtraction cloning approach we had previously isolated a series of murine cDNA clones representing the genes predominantly expressed in the embryonic brain and down-regulated during development. We now report that one of these cDNA clones encodes a novel type of GTP-binding protein. The predicted protein of 4...

journal_title：Biochemical and biophysical research communications

authors： Sazuka T,Tomooka Y,Ikawa Y,Noda M,Kumar S

更新日期：1992-11-30 00:00:00

abstract：:Intestinal challenge with cholera toxin induces the synthesis of a hormone-like protein which counteracts intestinal hypersecretion. This study shows that the protein also inhibits GABA transport across the plasma membrane of Deiters' cells in rabbits. The inhibitory action of the protein was dose dependent, and 10(3)...

journal_title：Biochemical and biophysical research communications

authors： Lange S,Lönnroth I,Palm A,Hydén H

更新日期：1985-08-15 00:00:00

abstract：:The patients suffering from acidosis usually sign psychological deficits. The cerebral dysfunction is reportedly caused by an acid-induced functional impairment of GABAergic neurons; however, the role of pyramidal neurons in this process remains unclear. By using electrophysiological method and changing extracellular ...

journal_title：Biochemical and biophysical research communications

authors： Zhao H,Cai Y,Yang Z,He D,Shen B

更新日期：2011-11-18 00:00:00

abstract：:Deficiency in the DNA mismatch repair (MMR) is frequently involved in various cancers. The hMSH3 gene is one of the human MMR genes whose role in bladder cancer is not known. We hypothesized that down-regulation of the hMSH3 gene might be involved in bladder cancer. In this study we analyzed this gene with regard to f...

journal_title：Biochemical and biophysical research communications

authors： Kawakami T,Shiina H,Igawa M,Deguchi M,Nakajima K,Ogishima T,Tokizane T,Urakami S,Enokida H,Miura K,Ishii N,Kane CJ,Carroll PR,Dahiya R

更新日期：2004-12-17 00:00:00

abstract：:The effect of HMG1 on the transcriptional block caused by left-handed Z-form in a highly negatively supercoiled DNA was examined using a supercoiled plasmid containing a (CG)10 sequence downstream of promoters. The transcription by E. coli RNA polymerase was blocked at the boundary of alternating CG sequence in the Z-...

journal_title：Biochemical and biophysical research communications

authors： Waga S,Mizuno S,Yoshida M

更新日期：1988-05-31 00:00:00

abstract：:Rats consume most of their daily food intake at night; serum leptin levels and adipose tissue leptin mRNA content are elevated at night in non-lactating rats fed ad libitum. Lactation induces massive hyperphagia with most food still consumed at night, but the nocturnal increase in leptin secretion was not observed in ...

journal_title：Biochemical and biophysical research communications

authors： Pickavance L,Tadayyon M,Williams G,Vernon RG

更新日期：1998-07-09 00:00:00

abstract：:A cDNA clone of an alpha subunit of the human GABA-A receptor has been isolated. The human clone (pCLL800) contains 1055 nucleotides in an open reading frame and 260 nucleotides in the 5' non-coding region. The 351 amino acid sequence of this human alpha subunit shows 97% homology with its bovine counterpart. Hybridiz...

journal_title：Biochemical and biophysical research communications

authors： Garrett KM,Duman RS,Saito N,Blume AJ,Vitek MP,Tallman JF

更新日期：1988-10-31 00:00:00

abstract：:The small heat shock proteins are the ubiquitous proteins found in a wide range of organisms and function as molecular chaperones by binding to the folding intermediates of their substrates. Although the crystal structure of HSP16.5, a small heat shock protein from Methanococcus jannaschii, revealed that it is a hollo...

journal_title：Biochemical and biophysical research communications

authors： Kim DR,Lee I,Ha SC,Kim KK

更新日期：2003-08-08 00:00:00

abstract：:We have deduced the exon structure of the 5' untranslated region of the human cardiac alpha-myosin heavy chain gene by cloning a cDNA for this region using the polymerase chain reaction. Comparison of the cDNA and genomic DNA sequences demonstrates that the 5' non-coding region of the alpha-myosin heavy chain gene is ...

journal_title：Biochemical and biophysical research communications

authors： Brand NJ,Dabhade N,Yacoub M,Barton PJ

更新日期：1991-09-30 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) may play important roles during hepatitis B virus (HBV) infection. In this study, we used a recombinant human soluble death receptor 5 (sDR5) to explore its effect in a mouse model of HBV-induced acute hepatitis. By measuring blood transaminase activity a...

journal_title：Biochemical and biophysical research communications

authors： Liu YG,Liu SX,Liang XH,Zhang Q,Gao LF,Han LH,Cao YL,Hou N,Du J,Sun WS

更新日期：2007-01-12 00:00:00

abstract：:The ubiquitously expressed Calpains 1 and 2 belong to a family of calcium-dependent intracellular cysteine proteases. Both calpains are heterodimers consisting of a large subunit and a small regulatory subunit encoded by the gene Capns1. To investigate a role for the calpain small subunit in cells of the osteoblast li...

journal_title：Biochemical and biophysical research communications

authors： Kashiwagi A,Fein MJ,Shimada M

更新日期：2011-06-03 00:00:00

abstract：:Using baculoviral and bacterial systems, we expressed biologically active recombinant rat IL-13 and generated neutralizing rat IL-13 antiserum. Recombinant rat IL-13 produced by baculovirus-infected insect cells stimulated proliferation of TF-1 premyeloid cell line and induced expression of 15-lipoxygenase mRNA in hum...

journal_title：Biochemical and biophysical research communications

authors： Lakkis FG,Cruet EN,Nassar GM,Badr KF,Pascual DW

更新日期：1997-06-27 00:00:00

abstract：:The addition of the tumor-promoting phorbol 12-myristate, 13-acetate to rabbit neutrophils greatly potentiates the effect of the calcium ionophore A23187 on [3H]-arachidonic acid release and [32P]-phosphatidic acid generation. At 5 X 10(-8) M A23187, the addition of 20 ng/ml PMA potentiates the action of the ionophore...

journal_title：Biochemical and biophysical research communications

authors： Volpi M,Molski TF,Naccache PH,Feinstein MB,Sha'afi RI

更新日期：1985-04-30 00:00:00

abstract：:Although a majority of regulatory peptides elaborated by neuroendocrine cells are small, i.e., less than 50-60 residues, no low-molecular-weight, bone-derived mitogenic peptides have been described. We have size-fractionated extracts of neonatal mouse calvaria, a rapidly forming bone, and assayed for osteoblast prolif...

journal_title：Biochemical and biophysical research communications

authors： Birnbaum RS,Andress DL

更新日期：1990-11-30 00:00:00

abstract：:When human ovarian carcinoma cells are challenged with endotoxin, an I kappa B kinase is transiently induced within 3 to 5 min. This enzyme activity causes the hyperphosphorylation and subsequent degradation of I kappa B which allows NF-kappa B to translocate to the nucleus where it activates transcription. When endot...

journal_title：Biochemical and biophysical research communications

authors： Kohler NG,Joly A

更新日期：1997-03-27 00:00:00

abstract：:The 65 kDa C8-binding protein or homologous restriction factor (C8bp/HRF) protects cells from complement (C)-mediated lysis by binding to C8 and abrogating lytic channel formation. Human C8bp/HRF is shown here to be immunologically related to human C8 and C9 and to murine lymphocyte poreforming protein (PFP, perforin)...

journal_title：Biochemical and biophysical research communications

authors： Young JD,Rosse WF,Hasselkus-Light CS

更新日期：1990-01-30 00:00:00

abstract：:Thrombomodulin (TM) is a cell-surface glycoprotein and a critical mediator of endothelial anticoagulant function. TM exists as both a chondroitin sulfate (CS) proteoglycan (PG) form and a non-PG form lacking a CS chain (α-TM); therefore, TM can be described as a part-time PG. Previously, we reported that α-TM bears an...

journal_title：Biochemical and biophysical research communications

authors： Izumikawa T,Kitagawa H

更新日期：2015-05-01 00:00:00

abstract：:Apigenin, a plant flavonoid, induced the reversion of transformed phenotypes of v-H-ras-transformed NIH 3T3 cells at a quite low concentration of 12.5 microM. In the present study, we have examined the components of this Ras-mediated signaling transduction to determine whether they were involved in the apigenin-induce...

journal_title：Biochemical and biophysical research communications

authors： Kuo ML,Yang NC

更新日期：1995-07-26 00:00:00