Low-molecular-weight peptides in bone extracts that stimulate osteoblast mitogenesis.

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) holds promising value for cancer therapy due to its capacity to induce apoptosis in cancer cells. Nevertheless, TRAIL therapy is greatly hampered by its resistance. Irigenin (Iri), isoflavonoids, can be isolated from the rhizome of Belamcanda chinensis, a...

journal_title：Biochemical and biophysical research communications

authors： Xu Y,Gao CC,Pan ZG,Zhou CW

更新日期：2018-02-12 00:00:00

abstract：:Although it is recognized that 4,5-diaminovaleric acid, formed from glutamate 1-semialdehyde, functions as the intermediate in the last step of delta-aminolevulinic acid formation from glutamate, the enantioselectivity of the participating glutamate 1-semialdehyde aminotransferase for 4,5-diaminovaleric acid has remai...

journal_title：Biochemical and biophysical research communications

authors： Friedmann HC,Duban ME,Valasinas A,Frydman B

更新日期：1992-05-29 00:00:00

abstract：:The MUC1 transmembrane glycoprotein is aberrantly overexpressed in diverse human carcinomas and has been shown to inhibit apoptosis induced by genotoxic agents. In the present work, we report that MUC1 binds to and activates JNK1, an important member of the mitogen-activated protein kinases (MAPK) superfamily. The phy...

journal_title：Biochemical and biophysical research communications

authors： Chen Q,Li D,Ren J,Li C,Xiao ZX

更新日期：2013-10-11 00:00:00

abstract：:Although it is widely accepted that insulin stimulates leptin secretion, a dual action was observed using a validated in vitro system, i.e., an early (less than 48 h) inhibitory action, followed later (48-96 h) by a clear-cut stimulation. While the inhibitory phase was observed at every glucose concentration tested (f...

journal_title：Biochemical and biophysical research communications

authors： Casabiell X,Piñeiro V,De la Cruz LF,Gualillo O,Folgar L,Diéguez C,Casanueva FF

更新日期：2000-09-24 00:00:00

abstract：:The clinical effects of serpin polymerisation include thromboembolism, emphysema, and liver disease. A through understanding of serpin polymerisation mechanisms and the structures involved will permit the rational design of therapeutic polymerisation inhibitors. Here we show that serpin polymerisation can be delayed b...

journal_title：Biochemical and biophysical research communications

authors： Bottomley SP,Chang WS

更新日期：1997-12-18 00:00:00

abstract：:Vascular endothelial growth factor (VEGF), also known as vascular permeability factor, is highly expressed in the myocardium under various stimuli including hypoxia and ischemia. On the other hand, lipopolysaccharide (LPS) causes systemic inflammatory response syndrome (SIRS), which consists of systemic pathophysiolog...

journal_title：Biochemical and biophysical research communications

authors： Sugishita Y,Shimizu T,Yao A,Kinugawa Ki,Nojiri T,Harada K,Matsui H,Nagai R,Takahashi T

更新日期：2000-02-16 00:00:00

abstract：:The effects of dopamine (DA) on 45Ca2+ ion movement and prolactin release in dispersed female rat anterior pituitary cells were studied to elucidate the mechanism for DA reduction of intracellular calcium levels. In 45Ca2+ prelabeled cells, DA inhibited fractional calcium efflux and prolactin release simultaneously an...

journal_title：Biochemical and biophysical research communications

authors： Login IS,Judd AM,MacLeod RM

更新日期：1988-03-15 00:00:00

abstract：:ELOVL3 is involved in elongating saturated and monounsaturated fatty acids, and is a critical enzyme for lipid accumulation in brown adipocytes during the early phase of tissue recruitment. In addition, ELOVL3 is related to increased fatty acid oxidation in brown adipocytes. However, the potential functions of ELOVL3 ...

journal_title：Biochemical and biophysical research communications

authors： Liu D,Xu JH,Tong HL,Li SF,Yan YQ

更新日期：2017-12-02 00:00:00

abstract：:Hepatitis C virus (HCV) causes chronic hepatitis C (CH-C) and is epidemiologically linked with the occurrence of hepatocellular carcinoma (HCC). To elucidate the comprehensive gene expression profiles of CH-C and HCC, serial analysis of gene expression (SAGE) libraries were made from CH-C and HCC tissues of a patient,...

journal_title：Biochemical and biophysical research communications

authors： Yamashita T,Kaneko S,Hashimoto S,Sato T,Nagai S,Toyoda N,Suzuki T,Kobayashi K,Matsushima K

更新日期：2001-03-30 00:00:00

abstract：:The human EBAG9 was previously identified as an estrogen responsive gene using CpG-genomic binding site cloning (Watanate et al., (1998) Mol. Cell. Biol. 18: 442-449). Recently it was revealed that the EBAG9 is identical with RCAS1 which is a cancer cell surface antigen implicated in immune escape. Here, we isolated a...

journal_title：Biochemical and biophysical research communications

authors： Ikeda K,Sato M,Tsutsumi O,Tsuchiya F,Tsuneizumi M,Emi M,Imoto I,Inazawa J,Muramatsu M,Inoue S

更新日期：2000-07-05 00:00:00

abstract：:Copper ions reportedly bind to the cellular prion (PrPC) and induce PrP proteinase K (PK) resistant from (PrPres). PrPC also plays a role in response to oxidative stress. By using purified human PrP23-98 containing octarepeats, we have found that Cu(II) induces PrPres determined by Western blots and atomic force micro...

journal_title：Biochemical and biophysical research communications

authors： Lu B,Zhao L,Qin K

更新日期：2018-05-15 00:00:00

abstract：:Osterix (Osx) has been shown to be an osteoblast-specific transcription factor for bone formation. Recently, it has been reported that Osx is significantly expressed in the mouse olfactory bulb, proving that Osx may play a role in olfactory bulb development, as well as bone development. Here, we studied morphological ...

journal_title：Biochemical and biophysical research communications

authors： Park JS,Park GI,Kim JE

更新日期：2016-09-09 00:00:00

abstract：:Bile acids of patients with renal failure and of healthy subjects were analyzed by capillary gas chromatography after group separation. The amount of bile acids in the total dialysate (150 L) of the patients was smaller than that in the 24-h urine of healthy subjects. Polar bile acid sulfates constituted 17.3% and 30....

journal_title：Biochemical and biophysical research communications

authors： Yamaga N,Adachi K,Kohara H,Shimizu K

更新日期：1988-04-15 00:00:00

abstract：:Yes-associated protein (YAP) is a key downstream effector of the highly conserved Hippo signaling pathway, which regulates organ size, regeneration and tumorigenesis. Known classically to function as a transcriptional co-activator, YAP interacts with TEA domain transcription factors (TEAD1-4) to induce expression of t...

journal_title：Biochemical and biophysical research communications

authors： Wen Z,Wang Y,Qi S,Ma M,Li J,Yu FX

更新日期：2020-10-15 00:00:00

abstract：:(15)N and (1)HN chemical shift data and (15)N relaxation studies have been used to characterise the binding of N-phenyl-naphthylamine (NPN) to mouse major urinary protein (MUP). NPN binds in the beta-barrel cavity of MUP, hydrogen bonding to Tyr120 and making extensive non-bonded contacts with hydrophobic side chains....

journal_title：Biochemical and biophysical research communications

authors： Pertinhez TA,Ferrari E,Casali E,Patel JA,Spisni A,Smith LJ

更新日期：2009-12-25 00:00:00

abstract：:We have used HL-60 leukemia cells to investigate phosphatidylinositol 3-kinase (PI 3-K) during granulocytic differentiation at the nuclear level. Nuclei of HL-60 cells showed a constitutive presence of PI 3-K that increased when cells were treated with differentiating doses of ATRA. PI 3-K was also detected tightly bo...

journal_title：Biochemical and biophysical research communications

authors： Marchisio M,Bertagnolo V,Colamussi ML,Capitani S,Neri LM

更新日期：1998-12-18 00:00:00

abstract：:Ritonavir, an inhibitor of HIV-1 protease, has been reported to also inhibit the Ca2+-dependent cysteine protease, calpain. We have investigated these claims with an in vitro study of the effect of ritonavir on the m-calpain and mu-calpain isoforms. Ritonavir failed to block either autolytic or hydrolytic calpain acti...

journal_title：Biochemical and biophysical research communications

authors： Cuerrier D,Nie Z,Badley AD,Davies PL

更新日期：2005-02-04 00:00:00

abstract：:To investigate the effects of ethanolamine plasmalogen, phosphatidylethanolamine, cholesterol, and alpha-tocopherol on the oxidizability of membranes, various large unilamellar vesicles (LUVs) including these lipids and antioxidant were examined for their total membrane oxidizabilities, evaluated as R(p)/R(i)(1/2) val...

journal_title：Biochemical and biophysical research communications

authors： Maeba R,Ueta N

更新日期：2003-03-07 00:00:00

abstract：:Human erythrocytes express a p57 membrane serine proteinase which cleaves C3, the third component of complement. Amino acid analysis of the first 20 N-terminal residues of the purified p57 proteinase demonstrated 100% homology with residues 910-929 of erythrocyte ankyrin, a sequence localized in its Mr = 62 kDa fragme...

journal_title：Biochemical and biophysical research communications

authors： Hermann J,Barel M,Frade R

更新日期：1994-10-28 00:00:00

abstract：:Chemerin is a chemoattractant cytokine (chemokine) produced by adipocytes and hepatocytes; it regulates insulin sensitivity and adipocyte differentiation. The objective of this study was to investigate the effect of chemerin on the expression of genes related to lactogenesis and the regulators of chemerin signaling in...

journal_title：Biochemical and biophysical research communications

authors： Suzuki Y,Haga S,Katoh D,So KH,Choi KC,Jung US,Lee HG,Katoh K,Roh SG

更新日期：2015-10-23 00:00:00

abstract：:The extended exposure of proteins to reducing sugars leads to nonenzymatic glycation with the accumulation of advanced glycation end products (AGEs). Long-lived proteins, such as collagen and crystallins, are subjected to this modification, and are implicated as causal factors in several diseases including diabetic co...

journal_title：Biochemical and biophysical research communications

authors： Hong SB,Lee KW,Handa JT,Joo CK

更新日期：2000-08-18 00:00:00

abstract：:In isolated rat pancreatic acini, protein expression of RhoA and Rho-associated kinase, ROCK-II, and the formation of immunocomplex of RhoA with ROCK-II were enhanced by CCK-8, carbachol, and the phorbol ester TPA. The ROCK-specific inhibitor, Y-27632, did not alter basal amylase secretion, whereas it potentiated CCK-...

journal_title：Biochemical and biophysical research communications

authors： Kusama K,Nozu F,Awai T,Tanaka S,Honma I,Tsunoda Y,Mitamura K

更新日期：2003-05-30 00:00:00

abstract：:Plasma membrane receptors can undergo translocation in the plane of plasma membrane after binding of polyvalent ligands. Ligand/receptor clusters, named patches, can collect into a polar cap, presumably due to their association with the submembrane actin-based cytoskeleton. We found that the assembly of Fcgamma recept...

journal_title：Biochemical and biophysical research communications

authors： Kwiatkowska K,Sobota A

更新日期：1999-06-07 00:00:00

abstract：:A Y-box binding protein ChYB-1 was discovered as a ChHsc70 promoter-associated protein in Crassostrea hongkongensis by DNA-affinity purification and mass spectrometry analysis. The overexpression of ChYB-1 in heterologous HEK293T cells led to clear enhancement of ChHsc70 promoter expression, while ChYB-1 depletion cor...

journal_title：Biochemical and biophysical research communications

authors： Liu H,Xu D,Cui M,Hou T,Zhang Q

更新日期：2018-01-22 00:00:00

abstract：:Lipocortin I-S100 (calcyclin) heterotetramer exhibited ATPase activity in the presence of dsDNA but not ssDNA. To demonstrate its helicase activity, an 80-mer polynucleotide complementary to the replication origin of M13mp18 was synthesized, and the oligonucleotide, (dC)(20), was ligated to either its 5'- or 3'- end f...

journal_title：Biochemical and biophysical research communications

authors： Hirata A,Hirata F

更新日期：2002-02-22 00:00:00

abstract：:A direct radioimmunoassay for the rapid and accurate detection of human ANP from unextracted plasma is described. The sensitivity was approximately 50 pg/ml, respectively 2.5 pg/tube, the intra-assay variation 4%, and the inter-assay variation less than 12%. Rat ANP (1-28, 5-25, 5-27 and 5-28), oxydized and reduced hA...

journal_title：Biochemical and biophysical research communications

authors： Jüppner H,Brabant G,Kapteina U,Kirschner M,Klein H,Hesch RD

更新日期：1986-09-30 00:00:00

abstract：:Rapidly activating Kv4 voltage-gated ion channels are found in heart, brain, and diverse other tissues including colon and uterus. Kv4.3 can co-assemble with KChIP ancillary subunits, which modify kinetic behavior. We examined the affinity and use dependence of nifedipine block on Kv4.3 and its modulation by KChIP2b. ...

journal_title：Biochemical and biophysical research communications

authors： Bett GC,Morales MJ,Strauss HC,Rasmusson RL

更新日期：2006-02-24 00:00:00

abstract：:15(S)-15-methyl-prostaglandin E1 and prostaglandin I2 rapidly and reversibly inhibit formyl-methionyl-leucyl-phenylalanine induced superoxide production by human neutrophils. In contrast, 15(S)-15-methyl-prostaglandin E1 and prostaglandin I2 did not alter the rate or the total amount of superoxide production by human ...

journal_title：Biochemical and biophysical research communications

authors： Fantone JC,Kinnes DA

更新日期：1983-06-15 00:00:00

abstract：:Pigment epithelial-derived factor (PEDF) is a multifunctional secreted glycoprotein, which could protect against hypoxia-induced cell death related to its anti-oxidative effect in cultured cardiomyocytes. However, the pathway mediating this cytoprotective process has not been fully established. Here we confirmed that ...

journal_title：Biochemical and biophysical research communications

authors： Wang X,Zhang Y,Lu P,Zhang H,Li Y,Dong H,Zhang Z

更新日期：2015-09-25 00:00:00

abstract：:To simultaneously assess the effects of exonic mutations on RNA splicing and protein functions, we report here an intron-inclusive cDNA (Intinc) expression system. As a test model, twenty-four mutations in exon 9 of the phenylalanine hydroxylase (PAH) gene were examined in an Intinc expression plasmid composed of the ...

journal_title：Biochemical and biophysical research communications

authors： Ho PY,Huang MZ,Fwu VT,Lin SC,Hsiao KJ,Su TS

更新日期：2008-09-05 00:00:00