当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Lipopolysaccharide augments expression and secretion of vascular endothelial growth factor in rat ventricular myocytes.

Lipopolysaccharide augments expression and secretion of vascular endothelial growth factor in rat ventricular myocytes.

Abstract：

:Vascular endothelial growth factor (VEGF), also known as vascular permeability factor, is highly expressed in the myocardium under various stimuli including hypoxia and ischemia. On the other hand, lipopolysaccharide (LPS) causes systemic inflammatory response syndrome (SIRS), which consists of systemic pathophysiological changes related to vascular hyperpermeability. To test the hypothesis that VEGF is one of the important mediators of SIRS, we examined effects of LPS on the VEGF expression and secretion in cultured neonatal rat ventricular myocytes. LPS (10 microg/ml) rapidly (within 1 h) augmented the levels of VEGF mRNA in these cells. Pharmacological inhibition of nucleic factor-kappaB or tyrosine kinases did not affect the LPS-induced augmentation of VEGF mRNA expression, while these treatments markedly suppressed the up-regulation of inducible nitric oxide synthase (iNOS) expression by LPS. The VEGF concentrations in the conditioned media were also significantly increased by the LPS treatment of 6 h. In conclusion, LPS augments VEGF expression and secretion in rat ventricular myocytes, suggesting that VEGF may be involved in pathogenesis of SIRS. LPS may induce VEGF mRNA through the signaling pathways that are distinct from those responsible for the iNOS induction.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Sugishita Y,Shimizu T,Yao A,Kinugawa Ki,Nojiri T,Harada K,Matsui H,Nagai R,Takahashi T

doi

10.1006/bbrc.2000.2165

subject

Has Abstract

pub_date

2000-02-16 00:00:00

pages

657-62

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006291X0092165X

journal_volume

268

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • The H159A mutant of yeast enolase 1 has significant activity.

    abstract：:The function of His159 in the enolase mechanism is disputed. Recently, Vinarov and Nowak (Biochemistry (1999) 38, 12138-12149) prepared the H159A mutant of yeast enolase 1 and expressed this in Escherichia coli. They reported minimal (ca. 0.01% of the native value) activity, though the protein appeared to be correctly...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2000.3618

    authors： Brewer JM,Holland MJ,Lebioda L

    更新日期：2000-10-05 00:00:00

  • An amino acid exchange in exon I of the human lecithin: cholesterol acyltransferase (LCAT) gene is associated with fish eye disease.

    abstract：:The exons of the lecithin:cholesterol acyltransferase (LCAT) gene in DNA samples from two of the original Swedish Fish Eye Disease patients have been amplified by polymerase chain reactions and sequenced by the dideoxy method. The two patients apparently were unrelated. In both patients a mutation in codon 10 of the f...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(92)91772-i

    authors： Skretting G,Prydz H

    更新日期：1992-01-31 00:00:00

  • Caffeine lengthens circadian rhythms in mice.

    abstract：:Although caffeine alters sleep in many animals, whether or not it affects mammalian circadian clocks remains unknown. Here, we found that incubating cultured mammalian cell lines, human osteosarcoma U2OS cells and mouse fibroblast NIH3T3 cells, with caffeine lengthened the period of circadian rhythms. Adding caffeine ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.06.049

    authors： Oike H,Kobori M,Suzuki T,Ishida N

    更新日期：2011-07-08 00:00:00

  • Identification, structural determination, and biological activity of bovine and canine calcitonin receptor-stimulating peptides.

    abstract：:We have recently identified in porcine brain a series of new peptides, designated calcitonin receptor-stimulating peptide-1 (CRSP-1), CRSP-2, and CRSP-3, but failed to find their counterparts in humans and rodents by either database searching or experimental cross-hybridization. In this study, we isolated cDNAs encodi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2003.11.114

    authors： Katafuchi T,Hamano K,Minamino N

    更新日期：2004-01-02 00:00:00

  • Stationary phase induced alterations in mycobacterial RNA polymerase assembly: A cue to its phenotypic resistance towards rifampicin.

    abstract：:Rapid emergence of multi-drug resistance in Mycobacterium tuberculosis has necessitated the development of newer candidate drugs which can selectively inhibit the growth of the organism. Among the best targets available today, transcription machinery is, by far, the most important one and the antibiotic rifampicin bin...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.02.118

    authors： Mukherjee R,Chatterji D

    更新日期：2008-05-09 00:00:00

  • A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression.

    abstract：:Upon binding of a Wnt to its receptor, GSK3beta is inhibited through an unknown mechanism involving Dishevelled (Dsh), resulting in the dephosphorylation and stabilization of beta-catenin, which translocates to the nucleus and interacts with Lef/Tcf transcription factors to activate target gene expression. Axin is a s...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.1760

    authors： Jho Eh,Lomvardas S,Costantini F

    更新日期：1999-12-09 00:00:00

  • A serum exosomal microRNA panel as a potential biomarker test for gastric cancer.

    abstract：:The findings from several studies have suggested that circulating miRNAs are imbalanced with the genesis of gastric cancer (GC). Both normal and cancer cells can generate and secrete exosomes, which are nanosized membrane vesicles that can transport microRNAs and proteins. Emerging evidence indicates that the exosomes...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.10.003

    authors： Wang N,Wang L,Yang Y,Gong L,Xiao B,Liu X

    更新日期：2017-11-25 00:00:00

  • Alcohol consumption during adolescence alters the hippocampal response to traumatic brain injury.

    abstract：:Binge drinking is the consumption of large volumes of alcohol in short periods and exerts its effects on the central nervous system, including the hippocampus. We have previously shown that binge drinking alters mitochondrial dynamics and induces neuroinflammation in the hippocampus of adolescent rats. Mild traumatic ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.05.160

    authors： Mira RG,Lira M,Quintanilla RA,Cerpa W

    更新日期：2020-07-30 00:00:00

  • Trans-activation of herpes simplex virus type 1 immediate early genes is specifically inhibited by human recombinant interferons.

    abstract：:The effect of human recombinant interferons (IFNs) alpha and gamma on the transcription of Herpes Simplex virus type-1 (HSV-1) immediate early (IE) genes has been studied. Human amniotic cells (WISH) were transfected with a chimaeric plasmid containing the regulatory region of the HSV-1 IE genes controlling the expres...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(89)90011-9

    authors： De Stasio PR,Taylor MW

    更新日期：1989-03-15 00:00:00

  • Expression of Aeromonas caviae ST pyruvate dehydrogenase complex components mediate tellurite resistance in Escherichia coli.

    abstract：:Potassium tellurite (K(2)TeO(3)) is harmful to most organisms and specific mechanisms explaining its toxicity are not well known to date. We previously reported that the lpdA gene product of the tellurite-resistant environmental isolate Aeromonas caviae ST is involved in the reduction of tellurite to elemental telluri...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.01.078

    authors： Castro ME,Molina RC,Díaz WA,Pradenas GA,Vásquez CC

    更新日期：2009-02-27 00:00:00

  • Regulation of Bcl-2 protein expression during oxidative stress in neuronal and in endothelial cells.

    abstract：:The relationship between oxidative stress and Bcl-2 expression was investigated in two different experimental models of oxidative stress. Acute oxidative stress was assessed by measuring, with fluorescence microscopy and cytofluorimetry, the increase in fluorescence of the oxidation-sensitive probe dihydrorhodamine 12...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.0928

    authors： Longoni B,Boschi E,Demontis GC,Marchiafava PL,Mosca F

    更新日期：1999-07-05 00:00:00

  • Identification and biological activities of a new antiangiogenic small molecule that suppresses mitochondrial reactive oxygen species.

    abstract：:Mitochondrial reactive oxygen species (ROS) are associated with multiple cellular functions such as cell proliferation, differentiation, and apoptosis. In particular, high levels of mitochondrial ROS in hypoxic cells regulate many angiogenesis-related diseases, including cancer and ischemic disorders. Here we report a...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.12.022

    authors： Kim KH,Park JY,Jung HJ,Kwon HJ

    更新日期：2011-01-07 00:00:00

  • GTP is required to stabilize and display transamidation activity of transglutaminase 2.

    abstract：:Transglutaminase 2 (TGase 2) is a bifunctional enzyme that catalyzes calcium-dependent transamidation and GTP binding/hydrolysis. The transamidation activity is proposed to be associated with several neurodegenerative disorders such as Alzheimer's and Hungtinton's disease. However, the regulation mechanism by which TG...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/S0006-291X(02)00582-X

    authors： Jeon JH,Cho SY,Kim CW,Shin DM,Kweon JC,Choi KH,Park SC,Kim IG

    更新日期：2002-06-21 00:00:00

  • 7-Ethoxyresorufin-O-deethylase activity in human hair roots: a potential marker for toxifying species of cytochrome P-450 isozymes.

    abstract：:Assay systems for the evaluation of carcinogen interaction with human tissues are essential for assessing cancer risk. Human hair roots (HHR) are a readily obtainable epithelial tissue source that have been employed for investigating inherited enzyme activities. In this study HHR were found to possess cytochrome P-450...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(87)90940-5

    authors： Merk HF,Mukhtar H,Schutte B,Kaufmann I,Das M,Bickers DR

    更新日期：1987-10-29 00:00:00

  • Effects of saponins of patrinia villosa against invasion and metastasis in colorectal cancer cell through NF-κB signaling pathway and EMT.

    abstract：BACKGROUND:Research has indicated that Herba Patriniae can suppress the growth of Several kinds of tumor cells in vitro and in vivo, thus displaying favorable antitumor activity. However, research regarding the effect of saponins of Patrinia villosa against CRC cell has not been reported. In the current study, We have ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.08.005

    authors： Xia L,Zhang B,Yan Q,Ruan S

    更新日期：2018-09-10 00:00:00

  • Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells.

    abstract：:ABCG2 (also called MXR (3), BCRP (4), or ABCP (5) is a recently-identified ABC half-transporter, which causes multidrug resistance in cancer. Here we report that the expression of the ABCG2 protein in Sf9 insect cells resulted in a high-capacity, vanadate-sensitive ATPase activity in isolated membrane preparations. AB...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.5130

    authors： Ozvegy C,Litman T,Szakács G,Nagy Z,Bates S,Váradi A,Sarkadi B

    更新日期：2001-07-06 00:00:00

  • NF-κB subunit RELA suppression of mucosa-associated lymphoid tissue lymphoma translocation protein 1 expression in oral carcinoma cells.

    abstract：:Loss of mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) expression closely associates with increased aggressive behaviors of oral carcinoma cells. It emphasizes that a mechanism to suppress the expression is an important subject for understanding carcinoma progression pathway. However, nothi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2021.01.025

    authors： Nozawa T,Mihara-Tomiyama N,Chiba T,Imai K

    更新日期：2021-01-19 00:00:00

  • ESR spin trapping investigation on peroxynitrite decomposition: no evidence for hydroxyl radical production.

    abstract：:The decomposition of peroxynitrite in the presence of 5,5-dimethyl-1-pyrroline N-oxide (DMPO) generated 5,5-dimethylpyrrolidone-(2)-oxy-(1) (DMPOX) without formation of DMPO/OH. Formate enhanced the peroxynitrite decomposition but did not generate any detectable amount of formate-derived free radicals. Glutathione, cy...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.2357

    authors： Shi X,Lenhart A,Mao Y

    更新日期：1994-09-30 00:00:00

  • Acetylsalicylic acid antagonizes the bleeding-induced changes in hemoglobin proportions in normal adult rats.

    abstract：:Normal adult Sprague-Dawley rats were made anemic by repeated phlebotomy. Ion-exchange chromatography of anemic blood showed newborn like hemoglobin proportions, involving the same six hemoglobin components as is found when newborn and adult blood are compared. However, acetylsalicylic acid intake during anemia failed...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(86)91176-9

    authors： Datta MC,Josephs J,Tolbert ME,Anderson J,Dowla H

    更新日期：1986-05-29 00:00:00

  • WITHDRAWN: Ambra1 modulates starvation-induced autophagy through AMPK signaling pathway in cardiomyocytes.

    abstract：:This article has been withdrawn at the request of the author(s). The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.05.007

    authors： Shi C,Wu J,Fu M,Zhang B,Wang J,Yang X,Chi Y

    更新日期：2014-05-10 00:00:00

  • Reconstitution of the NF1 GAP-related domain in NF1-deficient human Schwann cells.

    abstract：:Schwann cells derived from peripheral nerve sheath tumors from individuals with Neurofibromatosis Type 1 (NF1) are deficient for the protein neurofibromin, which contains a GAP-related domain (NF1-GRD). Neurofibromin-deficient Schwann cells have increased Ras activation, increased proliferation in response to certain ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.07.159

    authors： Thomas SL,Deadwyler GD,Tang J,Stubbs EB Jr,Muir D,Hiatt KK,Clapp DW,De Vries GH

    更新日期：2006-09-29 00:00:00

  • Atorvastatin inhibits angiotensin II-induced T-type Ca2+ channel expression in endothelial cells.

    abstract：:Ca2+ channels are involved in the regulation of vascular functions. Angiotensin II is implicated in the development of atherosclerosis and vascular remodeling. In this study, we demonstrated that angiotensin II preferentially increased the expression of alpha1G, a T-type Ca2+ channel subunit, via AT1 receptors in endo...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.06.084

    authors： Wang D,Hirase T,Inoue T,Node K

    更新日期：2006-08-25 00:00:00

  • A zinc finger protein TZF is a novel corepressor of androgen receptor.

    abstract：:Steroid hormones control the transcriptional activity of target genes mediated by intracellular nuclear receptors, and these transcriptional activities are modulated by the combination with coactivators and corepressors. We found in this study that testicular zinc finger protein (TZF) that was a nuclear protein with a...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.04.024

    authors： Ishizuka M,Kawate H,Takayanagi R,Ohshima H,Tao RH,Hagiwara H

    更新日期：2005-06-17 00:00:00

  • Paradoxical stimulation of both lipocortin and prostaglandin production in human amnion cells by dexamethasone.

    abstract：:Glucocorticoids inhibit prostaglandin biosynthesis by inducing the formation of lipocortins. In human amnion cells dexamethasone elicited a concentration-dependent increase in prostaglandin production and raised intracellular lipocortin 1 concentrations. Dexamethasone could also potentiate the epidermal growth factor ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(88)90569-4

    authors： Mitchell MD,Lytton FD,Varticovski L

    更新日期：1988-02-29 00:00:00

  • OK-1035, a selective inhibitor of DNA-dependent protein kinase.

    abstract：:Screening for inhibitors of DNA-dependent protein kinase (DNA-PK) revealed 3-cyano-5-(4-pyridyl)-6-hydrazonomethyl-2-pyridone, designated OK-1035, to be a potent and selective inhibitor. When a synthetic peptide was used as a substrate, OK-1035 caused 50% inhibition of DNA-PK activity at 8 microM, a concentration more...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.2431

    authors： Take Y,Kumano M,Hamano Y,Fukatsu H,Teraoka H,Nishimura S,Okuyama A

    更新日期：1995-10-04 00:00:00

  • Translocation of p190rho guanosine triphosphatase-activating protein from cytosol to the membrane in human neutrophils stimulated with different agonists.

    abstract：:In this paper, we investigated the subcellular distribution of p190rho guanosine triphosphatase-activating protein (p190 GAP) in human neutrophils stimulated with different agonists. The results show that in neutrophils treated with formyl-methionyl-leucyl-phenylalanine (FMLP) (1) p190 GAP was translocated from the cy...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.0323

    authors： Dusi S,Donini M,Wientjes F,Rossi F

    更新日期：1996-02-27 00:00:00

  • Effect of Ca2+ on the secondary structure of linear and cyclic collagen sequence analogs.

    abstract：:To investigate the role of secondary structure in the substrate specificity of human 72 kDa type IV collagenase, we synthesised linear and cyclic collagen sequence analogs. As Ca2+ plays a crucial role in the enzyme activity, the CD and FTIR spectra of the peptides were also measured in the presence of Ca2+. Most of t...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.1512

    authors： Likó Z,Botyánszki J,Bódi J,Vass E,Majer Z,Hollósi M,Süli-Vargha H

    更新日期：1996-10-14 00:00:00

  • Neutrophils and monocytes transport tumor cell antigens from the peritoneal cavity to secondary lymphoid tissues.

    abstract：:Antigen-transporting cells take up pathogens, and then migrate from sites of inflammation to secondary lymphoid tissues to induce an immune response. Among antigen-transporting cells, dendritic cells (DCs) are believed to be the most potent and professional antigen-presenting cells that can stimulate naïve T cells. Ho...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.10.011

    authors： Terasawa M,Nagata K,Kobayashi Y

    更新日期：2008-12-12 00:00:00

  • In situ hybridization patterns of zebrafish homeobox genes homologous to Hox-2.1 and En-2 of mouse.

    abstract：:Vertebrate homeobox genes have been identified on the basis of sequence homology to Drosophila segmentation and homeotic genes. We have analyzed the spatial distribution patterns in hatching larvae of transcripts from two different types of zebrafish (Brachydanio rerio) homeobox genes. Tritiated DNA fragments from one...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(88)80266-3

    authors： Njølstad PR,Fjose A

    更新日期：1988-12-15 00:00:00

  • 3D model of human arylamine N-acetyltransferase 2: structural basis of the slow acetylator phenotype of the R64Q variant and analysis of the active-site loop.

    abstract：:The human arylamine N-acetyltransferase NAT2 is responsible for the biotransformation of numerous arylamine drugs and carcinogens. A common polymorphism of the NAT2 gene has been associated with susceptibility to drug toxicity and various malignancies. In this study, we used the crystal structure of the Salmonella typ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2002.6414

    authors： Rodrigues-Lima F,Dupret JM

    更新日期：2002-02-15 00:00:00