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A zinc finger protein TZF is a novel corepressor of androgen receptor.

Abstract：

:Steroid hormones control the transcriptional activity of target genes mediated by intracellular nuclear receptors, and these transcriptional activities are modulated by the combination with coactivators and corepressors. We found in this study that testicular zinc finger protein (TZF) that was a nuclear protein with a zinc finger motif of the Cys2-His2 type was a novel corepressor of androgen receptor (AR). Fusion protein with green fluorescence protein GFP formed the specific foci in nuclei and TZF-dependent foci were located close to the splicing factor compartment. In addition, TZF was recruited into AR subnuclear foci after the treatment of dihydrotestosterone. Furthermore, we revealed that TZF bound to the activation function-1 (AF-1) domain (N-terminal transactivating domain) of AR protein. Transient over-expression of TZF in COS-7 cells or LNCaP human prostatic cancer cell resulted in decreased AR activity in a ligand-dependent fashion. Moreover, a transcriptional corepressor N-CoR additively decreased the transcriptional activity of AR with TZF. These findings suggest that TZF might be a novel corepressor of AR.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Ishizuka M,Kawate H,Takayanagi R,Ohshima H,Tao RH,Hagiwara H

doi

10.1016/j.bbrc.2005.04.024

subject

Has Abstract

pub_date

2005-06-17 00:00:00

pages

1025-31

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(05)00783-7

journal_volume

331

pub_type

杂志文章

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