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Exosome-associated hepatitis C virus in cell cultures and patient plasma.

Abstract：

:Hepatitis C virus (HCV) infects its target cells in the form of cell-free viruses and through cell-cell contact. Here we report that HCV is associated with exosomes. Using highly purified exosomes and transmission electron microscopic imaging, we demonstrated that HCV occurred in both exosome-free and exosome-associated forms. Exosome-associated HCV was infectious and resistant to neutralization by an anti-HCV neutralizing antibody. There were more exosome-associated HCV than exosome-free HCV detected in the plasma of HCV-infected patients. These results suggest exosome-associated HCV as an alternative form for HCV infection and transmission.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Liu Z,Zhang X,Yu Q,He JJ

doi

10.1016/j.bbrc.2014.10.146

subject

Has Abstract

pub_date

2014-12-12 00:00:00

pages

218-22

issue

3-4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(14)01975-5

journal_volume

455

pub_type

杂志文章

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