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Endotoxin protects the gastric mucosa against ulcerogenic stimuli.

Abstract：

:It is well-documented that large amounts of endotoxin produce hemorrhagic mucosal lesions in the stomach. To determine whether endotoxin, when injected at small doses, similarly exerts ulcerogenic actions, endotoxin (0.4-40 micrograms/kg) was injected into 24 hr-fasted rats. These small doses of endotoxin did not affect the integrity of the gastric mucosa. Unexpectedly, however, pretreatment with these minute amounts of endotoxin protected the gastric mucosa against various ulcerogenic stimuli such as stress, nonsteroidal anti-inflammatory drugs and ethanol. The anti-ulcer actions of endotoxin were not observed in endotoxin-insensitive animals (C3H/HeJ mice), thereby suggesting that endogenous cytokines such as interleukin-1 may mediate these protective actions. These findings stand in contrast to the toxic effect of endotoxin as an ulcerogen and indicate that endotoxin, albeit its term "toxin," may have a beneficial effect for the host.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Tsuji K,Uehara A,Santos SB,Namiki M

doi

10.1006/bbrc.1993.2622

subject

Has Abstract

pub_date

1993-12-30 00:00:00

pages

1326-33

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(83)72622-7

journal_volume

197

pub_type

杂志文章

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