Molecular characterization of the interleukin-8 receptor.

Abstract:

:Recently a rabbit cDNA (F3R) was characterized as binding and causing calcium mobilization induced by the formyl-methionine-leucine-phenylalanine peptide (fMLP). In the study reported here, cloned DNAs were isolated from rabbit genomic DNA by PCR based on the sequence of F3R. The cloned DNAs have several differences in the DNA sequence compared to the reported F3R sequence that alter the predicted protein sequence. COS-7 cells transfected with these clones in a mammalian expression vector bind human IL-8 with high affinity, but do not bind fMLP. We therefore believe that the cDNAs isolated encode the rabbit IL-8 receptor.

authors

Beckmann MP,Munger WE,Kozlosky C,VandenBos T,Price V,Lyman S,Gerard NP,Gerard C,Cerretti DP

doi

10.1016/0006-291x(91)91885-g

subject

Has Abstract

pub_date

1991-09-16 00:00:00

pages

784-9

issue

2

eissn

0006-291X

issn

1090-2104

pii

0006-291X(91)91885-G

journal_volume

179

pub_type

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