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RBM14 is indispensable for pluripotency maintenance and mesoderm development of mouse embryonic stem cells.

Abstract：

:The pluripotency of embryonic stem cells (ESCs) is maintained by core pluripotency transcription factors, cofactors and several signaling pathways. RBM14 is a component of the para-speckle complex, which has been implicated in multiple important biological processes. The role of RBM14 in ESCs and lineage differentiation remains to be elucidated. In the present study, we provided evidence that RBM14 plays important roles in maintaining pluripotency and in the early differentiation of ESCs. RBM14 was demonstrated to be expressed in mouse embryonic stem cells (mESCs) and localized in the nucleus. RBM14 expression was depleted in mESCs using clustered regularly interspaced short palindromic repeats (CRISPR) technology. Our results also showed that RBM14 depletion altered the gene expression profiles of mESCs. In particular, pluripotency-associated genes and genes involved in the Wnt and TGF-β signaling pathways were downregulated in RBM14 knockout mESCs. Furthermore, RBM14 was found to be essential for mesoderm development in vitro and in vivo. The specific effects of RBM14 depletion were verified by conducting a rescue experiment. Our findings demonstrated that RBM14 not only plays an important role in maintaining the pluripotency of mESCs but is also indispensable for mesoderm development.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Chen G,Zhang D,Zhang L,Feng G,Zhang B,Wu Y,Li W,Zhang Y,Hu B

doi

10.1016/j.bbrc.2018.04.231

subject

Has Abstract

pub_date

2018-06-18 00:00:00

pages

259-265

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(18)31035-0

journal_volume

501

pub_type

杂志文章

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