Abstract:
:Helodermin belongs to the VIP family of polypeptides. Recent in vivo data suggest that helodermin-like peptides might be involved in the regulation of calcium metabolism. We show that helodermin specifically binds to a secretin-type receptor in osteoblast-like cells from fetal rat calvaria and increases the basal and PTH-stimulated cAMP concentration of these cells. In organ cultures of fetal rat calvaria, helodermin strongly inhibits bone matrix apposition and augments PTH-induced bone resorption. Helodermin-like peptides may thus be capable of enhancing the direct effects of PTH on bone metabolism.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Pfeilschifter J,Naumann A,Oechsner M,Ziegler Rdoi
10.1016/0006-291x(90)92130-rsubject
Has Abstractpub_date
1990-07-31 00:00:00pages
576-81issue
2eissn
0006-291Xissn
1090-2104pii
0006-291X(90)92130-Rjournal_volume
170pub_type
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