Effects of helodermin on fetal rat bone metabolism in vitro.

Abstract:

:Helodermin belongs to the VIP family of polypeptides. Recent in vivo data suggest that helodermin-like peptides might be involved in the regulation of calcium metabolism. We show that helodermin specifically binds to a secretin-type receptor in osteoblast-like cells from fetal rat calvaria and increases the basal and PTH-stimulated cAMP concentration of these cells. In organ cultures of fetal rat calvaria, helodermin strongly inhibits bone matrix apposition and augments PTH-induced bone resorption. Helodermin-like peptides may thus be capable of enhancing the direct effects of PTH on bone metabolism.

authors

Pfeilschifter J,Naumann A,Oechsner M,Ziegler R

doi

10.1016/0006-291x(90)92130-r

subject

Has Abstract

pub_date

1990-07-31 00:00:00

pages

576-81

issue

2

eissn

0006-291X

issn

1090-2104

pii

0006-291X(90)92130-R

journal_volume

170

pub_type

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