DISC1-kendrin interaction is involved in centrosomal microtubule network formation.

Abstract:

:Disrupted-In-Schizophrenia 1 (DISC1) was identified as a novel gene disrupted by a (1;11)(q42.1;q14.3) translocation segregating with schizophrenia, bipolar disorder and other major mental illnesses in a Scottish family. We previously identified 446-533 amino acids of DISC1 as the kendrin-binding region by means of a directed yeast two-hybrid interaction assay and showed that the DISC1-kendrin interaction is indispensable for the centrosomal localization of DISC1. In this study, to confirm the DISC1-kendrin interaction, we examined the interaction between deletion mutants of DISC1 and kendrin. Then, we demonstrated that the carboxy-terminus of DISC1 is indispensable for the interaction with kendrin. Furthermore, the immunocytochemistry revealed that the carboxy-terminus of DISC1 is also required for the centrosomal targeting of DISC1. Overexpression of the DISC1-binding region of kendrin or the DISC1 deletion mutant lacking the kendrin-binding region impairs the microtubule organization. These findings suggest that the DISC1-kendrin interaction plays a key role in the microtubule dynamics.

authors

Shimizu S,Matsuzaki S,Hattori T,Kumamoto N,Miyoshi K,Katayama T,Tohyama M

doi

10.1016/j.bbrc.2008.10.100

subject

Has Abstract

pub_date

2008-12-26 00:00:00

pages

1051-6

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(08)02039-1

journal_volume

377

pub_type

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