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Regulation of Bcl-2 protein expression during oxidative stress in neuronal and in endothelial cells.

Abstract：

:The relationship between oxidative stress and Bcl-2 expression was investigated in two different experimental models of oxidative stress. Acute oxidative stress was assessed by measuring, with fluorescence microscopy and cytofluorimetry, the increase in fluorescence of the oxidation-sensitive probe dihydrorhodamine 123, both in retinal rod receptor cells exposed to bright light (0.32 mW/cm(2) for 15 minutes) and in human endothelial cells treated with the immunosuppressant cyclosporin A (200 microM for 21 h). In both cell types, acute oxidative stress reduced Bcl-2 expression and also caused a significant increase in the level of nucleosomes. Interestingly, chronic treatment with clinical concentrations of cyclosporin A (0.5-2.5 microM for 8 days) led to a significant increase in Bcl-2 expression, while nucleosomes were similar to control level. This suggests that up-regulation of Bcl-2 protein by low levels of oxidants may represent a critical factor in cellular adaptation to drug toxicity.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Longoni B,Boschi E,Demontis GC,Marchiafava PL,Mosca F

doi

10.1006/bbrc.1999.0928

subject

Has Abstract

pub_date

1999-07-05 00:00:00

pages

522-6

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(99)90928-2

journal_volume

260

pub_type

杂志文章

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