Structural features associated with alpha- anomeric in oligo-alpha-thymidylates.

Abstract:

:Comparison between gel electrophoresis migrations of oligo-alpha-thymidylates and oligo-beta-thymidylates indicates that the migration of alpha-oligonucleotides under native conditions is different from the migration of beta-oligonucleotides when the number of thymines, part of the sequence, is higher than 5. Such difference disappears when the gels are run under denaturing conditions. This, together with UV spectra, indicates that the structure of alpha-oligonucleotides is more organized than the structure of beta-oligonucleotides and that such an organisation appears for a length higher than 5 monomeric units.

authors

Bertrand JR,Bazile D,Malvy C,Paoletti J

doi

10.1016/0006-291x(90)91944-n

subject

Has Abstract

pub_date

1990-01-15 00:00:00

pages

293-8

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(90)91944-N

journal_volume

166

pub_type

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