Identification, structural determination, and biological activity of bovine and canine calcitonin receptor-stimulating peptides.

abstract：:Ritonavir, an inhibitor of HIV-1 protease, has been reported to also inhibit the Ca2+-dependent cysteine protease, calpain. We have investigated these claims with an in vitro study of the effect of ritonavir on the m-calpain and mu-calpain isoforms. Ritonavir failed to block either autolytic or hydrolytic calpain acti...

journal_title：Biochemical and biophysical research communications

authors： Cuerrier D,Nie Z,Badley AD,Davies PL

更新日期：2005-02-04 00:00:00

abstract：:Lipoprotein (a) [Lp(a)], a risk factor for coronary artery disease, is a LDL-like particle with apolipoprotein (a) [apo(a)] covalently linked to apolipoprotein B (apoB). Apo(a) has many repeats of kringle 4-like domain, classified as type 1 through type 10 (T1-T10). Deletion analysis was performed to define the functi...

journal_title：Biochemical and biophysical research communications

authors： Trieu VN,McConathy WJ

更新日期：1998-10-09 00:00:00

abstract：:In rodents, the transcription factors early growth response 2 (EGR2) and sterol regulatory element binding protein 1a (SREBP1a) regulate transcription of the stearoyl-CoA desaturase 2 (SCD2) gene during peripheral nerve myelination, which may be important for synthesis of the lipid component of myelin. Most non-rodent...

journal_title：Biochemical and biophysical research communications

authors： Lengi AJ,Corl BA

更新日期：2012-05-04 00:00:00

abstract：:The homeodomain transcription factor Phox2b is one of the key determinants involved in the development of noradrenergic (NA) neurons in both the central nervous system (CNS) and the peripheral nervous system (PNS). Using yeast two-hybrid screening, we isolated a Phox2b interacting protein, Trim11, which belongs to TRI...

journal_title：Biochemical and biophysical research communications

authors： Hong SJ,Chae H,Lardaro T,Hong S,Kim KS

更新日期：2008-04-11 00:00:00

abstract：:We tested usefulness of a target enrichment system SureSelect, a comprehensive viral nucleic acid detection method, for rapid identification of viral pathogens in feces samples of cattle, pigs and goats. This system enriches nucleic acids of target viruses in clinical/field samples by using a library of biotinylated R...

journal_title：Biochemical and biophysical research communications

authors： Oba M,Tsuchiaka S,Omatsu T,Katayama Y,Otomaru K,Hirata T,Aoki H,Murata Y,Makino S,Nagai M,Mizutani T

更新日期：2018-01-08 00:00:00

abstract：:Synthesis of melanin starts from the conversion of L-tyrosine to 3,4-dihydroxyphenylalanine (L-dopa) and then the oxidation of L-dopa yields dopaquinone by tyrosinase. Therefore, tyrosinase inhibitors have been established as important constituents of depigmentation agents. Recently, polyhydroxystilbene compounds, whi...

journal_title：Biochemical and biophysical research communications

authors： Ohguchi K,Tanaka T,Kido T,Baba K,Iinuma M,Matsumoto K,Akao Y,Nozawa Y

更新日期：2003-08-08 00:00:00

abstract：:Rearrangement of the p53 gene is frequent in virus transformed cell lines and in chronic myelogenous leukemia. It is a rare event in solid tumours and has been reported only in osteosarcomas. In this study we have examined rearrangement of the p53 gene in human breast tumours. We found rearrangement in 35% of the pati...

journal_title：Biochemical and biophysical research communications

authors： Nayak BK,Patnaik S,Das BR

更新日期：1998-04-17 00:00:00

abstract：:We questioned whether glucocorticoids alter the known potent effect of serum to increase glucose transport and GLUT-1 expression in cultured L6 myotubes. Myotubes were exposed to serum-free medium for 24h in the presence or absence of 300 nM dexamethasone and subsequently treated for 8h with 10% serum or serum free me...

journal_title：Biochemical and biophysical research communications

authors： Sivitz WI,Pasley AM

更新日期：1995-01-05 00:00:00

abstract：:It is known that fatty acids (FAs) regulate transcription through a number of FA responsive transcription factors. In order to investigate the effect of FAs on gene regulation in cultured human hepatocytes we examined the effect of palmitate on hepatic glucokinase (GK) promoter activity and expression of transcription...

journal_title：Biochemical and biophysical research communications

authors： Swagell CD,Henly DC,Morris CP

更新日期：2007-10-19 00:00:00

abstract：:Acute lung injury (ALI) is a severe clinical condition with high morbidity and mortality. Apoptosis is a key pathologic feature of ALI, and Bcl-2 plays an important role during the pathogenesis of ALI via the regulation of apoptosis. However, the regulation of Bcl-2 during ALI, particularly through microRNAs, remains ...

journal_title：Biochemical and biophysical research communications

authors： Zhao J,Li X,Zou M,He J,Han Y,Wu D,Yang H,Wu J

更新日期：2014-10-03 00:00:00

abstract：:Abnormal proliferation of vascular smooth muscle cells is a key event in the formation of atherosclerotic plaques in humans. It has been suggested that modulation of platelet derived growth factor chain A (PDGF-A) gene expression may contribute to atherosclerosis. Using an 'in situ hybridization' technique the present...

journal_title：Biochemical and biophysical research communications

authors： Zwijsen RM,Japenga SC,Heijen AM,van den Bos RC,Koeman JH

更新日期：1992-08-14 00:00:00

abstract：:Female Wistar rats were fed on a high fat diet for 18 weeks, during which their energy intake increased by 25% and body weight by 50% due to a doubling of adipose tissue tissue stores. Animals were then treated with increasing doses of a sheep polyclonal antiserum to rat adipocytes on days 1-4 and 7 after which they r...

journal_title：Biochemical and biophysical research communications

authors： Flint DJ

更新日期：1998-11-09 00:00:00

abstract：:The interaction of adrenodoxin (Adx) and NADPH cytochrome P450 reductase (CPR) with human microsomal steroidogenic cytochrome P450s was studied. It is found that Adx, mitochondrial electron transfer protein, is able to support reactions catalyzed by human microsomal P450s: full length CYP17, truncated CYP17, and trunc...

journal_title：Biochemical and biophysical research communications

authors： Pechurskaya TA,Harnastai IN,Grabovec IP,Gilep AA,Usanov SA

更新日期：2007-02-16 00:00:00

abstract：:Hypothalamic peptides, gonadotropin-releasing hormone (GnRH) and gonadotropin inhibitory hormone (GnIH), play pivotal roles in the control of reproduction and gonadal maturation in fish. In the present study we tested the possibility that stress-mediated reproductive dysfunction in teleost may involve changes in GnRH ...

journal_title：Biochemical and biophysical research communications

authors： Choi YJ,Habibi HR,Kil GS,Jung MM,Choi CY

更新日期：2017-04-01 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) expression is increased by hypertonicity. Therefore we hypothesized that hypertonicity increased PGE(2) can modulate the sodium transporters (Na(+)/K(+)-ATPase: NKA, epithelial sodium channel: ENaC, and sodium hydrogen exchanger: NHE) in M1 cortical collecting duct (CCD) cells. We demonstrated...

journal_title：Biochemical and biophysical research communications

authors： Nasrallah R,Paris G,Hébert RL

更新日期：2012-02-10 00:00:00

abstract：:This study examines the effect of TNFα on whole bovine intervertebral discs in organ culture and its association with changes characteristic of intervertebral disc degeneration (IDD) in order to inform future treatments to mitigate the chronic inflammatory state commonly found with painful IDD. Pro-inflammatory cytoki...

journal_title：Biochemical and biophysical research communications

authors： Purmessur D,Walter BA,Roughley PJ,Laudier DM,Hecht AC,Iatridis J

更新日期：2013-03-29 00:00:00

abstract：:Oxygen evolution from Triton X-100 prepared photosystem II particles from spinach was inhibited 70-80% after treatment of the particles with high concentrations of salt (0.5 or 1 M NaCl). The salt-washed preparations were depleted of 16 and 24 kilodalton polypeptides. Nearly complete restoration of herbicide-sensitive...

journal_title：Biochemical and biophysical research communications

authors： Nakatani HY

更新日期：1984-04-16 00:00:00

abstract：:Previous studies in our laboratory showed that ANP inhibits increases in endothelial monolayer permeability to macromolecules induced by thrombin. In this present study, we investigated the second messenger system involved in the influence of ANP on monolayer permeability. In bovine aortic endothelial cells (BAEC), AN...

journal_title：Biochemical and biophysical research communications

authors： Lofton CE,Newman WH,Currie MG

更新日期：1990-10-30 00:00:00

abstract：:We have isolated and purified to apparent homogeneity a serum protein which appears to be a biological marker for active rheumatoid arthritis. The protein has been found in the sera in all 44 active rheumatoid arthritis patients thus far studied and is absent from, or present in undetected amounts, in sera from normal...

journal_title：Biochemical and biophysical research communications

authors： Rosano CL,Parhami N,Hurwitz C

更新日期：1985-05-16 00:00:00

abstract：:Eukaryotic gene regulation is closely correlated with histone covalent modifications. Recently, histone H2B lysine-123 (H2B-K123) ubiquitination has been implicated in regulation of transcription as well as histone H3 lysine-4 (H3-K4) methylation which is further associated with active transcription. However, whether ...

journal_title：Biochemical and biophysical research communications

authors： Shukla A,Bhaumik SR

更新日期：2007-07-27 00:00:00

abstract：:Treatment of the cells of the 311 cell line, a pluripotent mouse teratocarcinoma cell line, with 12-O-tetradecanoylphorbol-13-acetate (TPA) modulates c-mos expression. Transient suppression of 6.1 and 4.6 kilobases (kb) transcripts and activation of 1.8 transcript indicate that TPA mediates concurrently positive and n...

journal_title：Biochemical and biophysical research communications

authors： Ogiso Y,Kitagawa K,Nishino H,Iwashima A

更新日期：1988-07-15 00:00:00

abstract：:A synthetic inhibitor of calpain protects rat erythrocyte membrane-associated cytoskeletal proteins from proteolytic degradation (IC50 = 1 microM) which occurs when the cells are rendered permeable to Ca++. Leupeptin, a naturally occurring inhibitor of the enzyme, does not afford any protection at concentrations up to...

journal_title：Biochemical and biophysical research communications

authors： Mehdi S,Angelastro MR,Wiseman JS,Bey P

更新日期：1988-12-30 00:00:00

abstract：:We have observed previously that Ca2+ pump-mediated Ca2+ efflux is elevated in cultured aortic smooth muscle cells from spontaneously hypertensive rats compared to those from Wistar-Kyoto rat controls. The objective of this work was to determine if these strains differ in mRNA levels for the PMCA1 isoform of the plasm...

journal_title：Biochemical and biophysical research communications

authors： Monteith GR,Kable EP,Kuo TH,Roufogalis BD

更新日期：1997-01-13 00:00:00

abstract：:To better understand the mechanism of interactions between G-protein-coupled melatonin receptors and their ligands, our previously reported homology model of human MT2 receptor with docked 2-iodomelatonin was further refined and used to select residues within TM3, TM6, and TM7 potentially important for receptor-ligand...

journal_title：Biochemical and biophysical research communications

authors： Mazna P,Berka K,Jelinkova I,Balik A,Svoboda P,Obsilova V,Obsil T,Teisinger J

更新日期：2005-07-08 00:00:00

abstract：:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) brings about a wide spectrum of toxic and biochemical changes, most of which are mediated by the AH receptor (AHR). Recent cloning of the AHR from the two most TCDD-resistant laboratory animals, Han/Wistar (Kuopio) rats and hamsters, suggested a critical role for the C-termin...

journal_title：Biochemical and biophysical research communications

authors： Korkalainen M,Tuomisto J,Pohjanvirta R

更新日期：2001-08-03 00:00:00

abstract：:Although insulin-like growth factors (IGF) I and II bind with high affinity to structurally discrete receptors, they bind with a lesser affinity to each other's receptor. We have evaluated the affinity of five different IGF-I preparations (three natural IGF-I preparations, one synthetic preparation, and one recombinan...

journal_title：Biochemical and biophysical research communications

authors： Rosenfeld RG,Conover CA,Hodges D,Lee PD,Misra P,Hintz RL,Li CH

更新日期：1987-02-27 00:00:00

abstract：:Anglerfish prosomatostatin II, the precursor of somatostatin-28 II, is produced in different cells from prosomatostatin I, by a cleavage at Arg73. Antibodies were raised against the carboxy-terminal [64-72] portion of the precursor II upstream from somatostatin-28 II sequence. These antibodies recognized only this epi...

journal_title：Biochemical and biophysical research communications

authors： Bourdais J,Devilliers G,Girard R,Morel A,Benedetti L,Cohen P

更新日期：1990-08-16 00:00:00

abstract：:Fas-associated protein with death domain (FADD) has been implicated in T lymphocytes, but the nature of FADD-dependent mechanism in early T cell development has not been completely elucidated. In this study, using T-cell specific deletion mice, we observed that FADD deficiency in thymocytes led to increased apoptosis ...

journal_title：Biochemical and biophysical research communications

authors： Zhang XY,Yang BY,Wang JY,Mo X,Zhang J,Hua ZC

更新日期：2014-08-22 00:00:00

abstract：:Heat shock proteins 60 (hsp60) and 10 (hsp10) are essential for the formation and restoration of many supramolecular structures. For reconstitution of these structures, we isolated stable hsps of 61kDa and 12kDa, which are similar to hsp60 and hsp10, respectively, from the supernatant fraction of thermophilic bacteriu...

journal_title：Biochemical and biophysical research communications

authors： Tamada H,Ohta T,Hamamoto T,Otawara-Hamamoto Y,Yanagi M,Hiraiwa H,Hirata H,Kagawa Y

更新日期：1991-08-30 00:00:00

abstract：:The effect of N-ethyl-5-phenylisoxazolium 3"-sulfonate (Woodward's reagent K, WRK), a reagent forming covalent bonds with protein carboxyl groups, on the activity of the mitochondrial phosphate carrier was investigated. Treatment with WRK of mitochondria or of extracted carrier incorporated into liposomes, inhibited p...

journal_title：Biochemical and biophysical research communications

authors： Wolf G,Genchi G,Palmieri F

更新日期：1989-07-14 00:00:00