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Inhibition of the mitochondrial phosphate carrier by a reaction with a carboxyl group reagent.

Abstract：

:The effect of N-ethyl-5-phenylisoxazolium 3"-sulfonate (Woodward's reagent K, WRK), a reagent forming covalent bonds with protein carboxyl groups, on the activity of the mitochondrial phosphate carrier was investigated. Treatment with WRK of mitochondria or of extracted carrier incorporated into liposomes, inhibited phosphate transport in a reconstituted liposomal system. Increasing the binding of WRK resulted in increased inhibition: the modified carrier protein showed a reduced affinity for phosphate, but binding of WRK had no effect on the Vmax of phosphate transport. It was concluded that WRK caused a conformational change in the carrier protein not involving the phosphate or H+ carrier sites such that its affinity for phosphate was lowered.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Wolf G,Genchi G,Palmieri F

doi

10.1016/0006-291x(89)91983-9

subject

Has Abstract

pub_date

1989-07-14 00:00:00

pages

212-6

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(89)91983-9

journal_volume

162

pub_type

杂志文章

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