Isolation of endo A cDNA from mouse 8-cell stage embryos.


:To analyse the species of genes expressed in a cleavage stage mouse embryo, we have constructed a cDNA library containing 3.0 x 10(5) independent clones from about 2 x 10(3) embryos at the 8-cell stage of development. Endo A cDNA prepared from parietal yolk sac endoderm like PYS-2 cells was used to screen the library. Southern blot analyses using the endo A sequence as a probe and restriction mapping analyses revealed that four independent recombinants had been inserted endo A sequence. Sequencing data of these clones showed that endo A mRNA present in the 8-cell stage embryo is identical to that of parietal yolk sac endoderm cells.


Nozaki M,Murata K,Morita T,Matsushiro A




Has Abstract


1988-08-15 00:00:00














  • Fission yeast LAMMER kinase Lkh1 regulates the cell cycle by phosphorylating the CDK-inhibitor Rum1.

    abstract::In eukaryotes, LAMMER kinases are involved in various cellular events, including the cell cycle. However, no attempt has been made to investigate the mechanisms that underlie the involvement of LAMMER kinase. In this study, we performed a functional analysis of LAMMER kinase using the fission yeast, Schizosaccharomyce...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Yu EY,Lee JH,Kang WH,Park YH,Kim L,Park HM

    更新日期:2013-03-01 00:00:00

  • Ceruloplasmin has two nearly identical sites that bind myeloperoxidase.

    abstract::Ceruloplasmin (Cp) is a copper-containing ferroxidase with potent antioxidant activity. Cp is expressed by hepatocytes and activated macrophages and has been known as physiologic inhibitor of myeloperoxidase (MPO). Enzymatic activity of MPO produces anti-microbial agents and strong prooxidants such as hypochlorous aci...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Bakhautdin B,Goksoy Bakhautdin E,Fox PL

    更新日期:2014-10-31 00:00:00

  • MicroRNA-2400 promotes bovine preadipocyte proliferation.

    abstract::MicroRNAs (miRNAs) play critical roles in the proliferation of bovine preadipocytes. miR-2400 is a novel and unique miRNA from bovines. In the present study, we separated and identified preadipocytes from bovine samples. miR-2400 overexpression increased the rate of preadipocyte proliferation, which was analyzed with ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Wei Y,Cui YF,Tong HL,Zhang WW,Yan YQ

    更新日期:2016-09-23 00:00:00

  • A novel redox-based switch: LMW-PTP oxidation enhances Grb2 binding and leads to ERK activation.

    abstract::Low molecular weight-PTP has been reported as a redox-sensitive protein during both platelet-derived growth factor and integrin signalling. In response to oxidation the phosphatase undergoes a reversible inactivation, which in turn leads to the increase in tyrosine phosphorylation of its substrates and the properly ex...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Giannoni E,Raugei G,Chiarugi P,Ramponi G

    更新日期:2006-09-22 00:00:00

  • POU-domain genes in planarian Dugesia japonica: the structure and expression.

    abstract::In fresh water planarian Dugesia japonica, two genes encoding POU-domain proteins, DjPOU1 and DjPOU2, have been identified by polymerase chain reaction (PCR). Their POU-domains are strikingly similar to class III POU-domains in mammals, frog, insects and nematode. The full-length cDNA of DjPOU1 has been cloned and seq...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Orii H,Agata K,Watanabe K

    更新日期:1993-05-14 00:00:00

  • Palmitate and inflammatory state additively induce the expression of PTP1B in muscle cells.

    abstract::The factors responsible for up-regulation of PTP1B, a negative regulator of insulin signaling, in insulin resistance state are not well understood. We performed a series of experiments in C2C12 muscle cells to determine the role of palmitate and an inflammatory state in regulation of PTP1B. Palmitate (0.75mM) induced ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Parvaneh L,Meshkani R,Bakhtiyari S,Mohammadtaghvaie N,Gorganifiruzjaee S,Taheripak G,Golestani A,Foruzandeh M,Larijani B,Taghikhani M

    更新日期:2010-05-28 00:00:00

  • Regulation of human hepatocyte gene expression by fatty acids.

    abstract::It is known that fatty acids (FAs) regulate transcription through a number of FA responsive transcription factors. In order to investigate the effect of FAs on gene regulation in cultured human hepatocytes we examined the effect of palmitate on hepatic glucokinase (GK) promoter activity and expression of transcription...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Swagell CD,Henly DC,Morris CP

    更新日期:2007-10-19 00:00:00

  • Interaction of Trypanosoma cruzi with cells with altered glycosylation patterns.

    abstract::Glycosylation mutants of chinese hamster ovary cells were used to analyse the role played by surface-exposed carbohydrates on the process of interaction of Trypanosoma cruzi with the host cell. Adhesion and invasion of the parasites were markedly reduced in cells which express very few sialic acid residues. Infection ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Ciavaglia Mdo C,de Carvalho TU,de Souza W

    更新日期:1993-06-15 00:00:00

  • Polyunsaturated fatty acids do not activate AMP-activated protein kinase in mouse tissues.

    abstract::Stearoyl-CoA desaturase 1 (SCD1) deficiency partitions fatty acids away from lipid synthesis towards fatty acid oxidation in liver and skeletal muscle in part due to activation of AMP-activated protein kinase (AMPK) pathway. The mechanism of AMPK activation by SCD1 mutation is unknown, however since SCD1-/- animals ha...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Dobrzyn A,Dobrzyn P,Miyazaki M,Ntambi JM

    更新日期:2005-07-08 00:00:00

  • Identification of glycyrrhizin-binding protein kinase as casein kinase II and characterization of its associated phosphate acceptors in mouse liver.

    abstract::Two forms (G-I and G-II kinases) of casein kinase II(CK-II) in a partially purified CK-II fraction (Mono Q fraction) of mouse liver were separated by means of glycyrrhizin (GL)-affinity column chromatography. Biochemical characterization revealed that these two GL-binding kinases were identical to CK-II. Two phosphate...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Harada S,Karino A,Shimoyama Y,Shamsa F,Ohtsuki K

    更新日期:1996-10-03 00:00:00

  • Structural characterization of thymidine phosphorylase purified from human placenta.

    abstract::Human thymidine phosphorylase (dThdPase) is thought to be identical to an angiogenesis factor, platelet-derived endothelial cell growth factor (PD-ECGF). However, the whole amino acid sequence of dThdPase is still unknown. N-terminal amino acid sequencing of dThdPase isolated from human placenta gave the sequence Ac-A...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Miyadera K,Dohmae N,Takio K,Sumizawa T,Haraguchi M,Furukawa T,Yamada Y,Akiyama S

    更新日期:1995-07-26 00:00:00

  • Specific binding sites for [3H]inositol(1,3,4,5)tetrakisphosphate on membranes of HL-60 cells.

    abstract::Membranes of HL-60 cells were shown to possess saturable binding sites for [3H]inositol(1,3,4,5)tetrakisphosphate, with nanomolar affinity (KD = 90 nM) and a density of 250 fmol/mg protein. The specificity of the binding sites for Ins(1,3,4,5)P4 was assessed by competition studies utilising a variety of inositol polyp...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Bradford PG,Irvine RF

    更新日期:1987-12-16 00:00:00

  • Stimulation of aromatase activity in immature porcine Leydig cells by fibroblast growth factor (FGF).

    abstract::The effects of fibroblast growth factor (FGF) on testicular aromatase activity has been studied using primary cultures of porcine Leydig cells. After culture for 3 days in the absence or presence of FGF, the ability of the cells to produce estrogen was examined in a 4h-test period in which either (a) hCG (10(-9) M) or...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Raeside JI,Berthelon MC,Sanchez P,Saez JM

    更新日期:1988-02-29 00:00:00

  • Somatostatin inhibits interleukin 6 release from rat cortical type I astrocytes via the inhibition of adenylyl cyclase.

    abstract::Interleukin 6 is a pleiotropic cytokine produced in the central nervous system (CNS) that has been involved in both direct neurotrophic activities and in the regulation of the production of acute phase proteins both at peripheral and central levels. In rat cortical type I astrocytes, interleukin 6 release is under the...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Grimaldi M,Florio T,Schettini G

    更新日期:1997-06-09 00:00:00

  • Treadmill running attenuates neonatal hypoxia induced adult depressive symptoms and promoted hippocampal neural stem cell differentiation via modulating AMPK-mediated mitochondrial functions.

    abstract::Neonatal hypoxia can induce the persisting brain dysfunctions and subsequently result in the behavioral abnormalities in adulthood. Improving mitochondrial functions were suggested as the effective strategy for brain functional recovery. In this study, we tested the effects of physical exercise, a well-established way...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Sun L,Ye R,Liang R,Xing F

    更新日期:2020-03-05 00:00:00

  • Bortezomib prevents the expression of MMP-13 and the degradation of collagen type 2 in human chondrocytes.

    abstract::The structural backbone of extracellular matrix in cartilage is the collagen fibril, which is mainly composed of type II collagen. A measurable increase in type II collagen denaturation and degradation has been found in early Osteoarthritis (OA). Pro-inflammatory cytokine such as TNF-α produced in OA cartilage induced...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Hu W,Zhang W,Li F,Guo F,Chen A

    更新日期:2014-09-26 00:00:00

  • Purification and characterization of 2-keto-3-deoxy-6-phosphogluconate aldolase from Azotobacter vinelandii: evidence that the enzyme is bifunctional towards 2-keto-4-hydroxy glutarate cleavage.

    abstract::2-keto-3-deoxy-6-phosphogluconate aldolase (E.C. has been purified in two chromatographic steps to 99% purity in 73% overall yield from Azotobacter vinelandii. The pure enzyme is a 70 kD trimeric Class I aldolase, inhibitable by bromopyruvate or pyruvate plus sodium borohydride, with a specific activity of 6...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Taha TS,Deits TL

    更新日期:1994-04-15 00:00:00

  • Targeting of renal proximal tubule Na,K-ATPase by salt-inducible kinase.

    abstract::The renal proximal tubule (RPT) is a central locale for Na+ reabsorption, and blood pressure regulation. Na+ reabsorption in the RPT depends upon the Na,K-ATPase, which is controlled by a complex regulatory network, including Salt-Inducible Protein Kinase (SIK). SIKs are recently discovered members of the AMP-activate...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章,评审


    authors: Taub M,Springate JE,Cutuli F

    更新日期:2010-03-12 00:00:00

  • IFN-gamma acts as anti-angiogenic cytokine in the human cornea by regulating the expression of VEGF-A and sVEGF-R1.

    abstract::Inflammatory processes within the cornea are known to be associated with corneal neovascularization (CN). We examined the effects of inflammatory mediators on the expression of angiogenic factors by corneal cells. TNF-alpha and IL-1 induced VEGF-A secretion by corneal fibroblasts (HCRF) and this was inhibited signific...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Kommineni VK,Nagineni CN,William A,Detrick B,Hooks JJ

    更新日期:2008-09-26 00:00:00

  • Phospholipase C mimics tumor promoter-induced chemiluminescence in murine epidermal cells.

    abstract::Treatment of newborn murine epidermal cells with phospholipase C results in the generation of a chemiluminescence response similar to that previously described for phorbol ester tumor promoters. Based on inhibitor studies, the oxidant, believed to be superoxide anion, is most likely generated from lipoxygenase metabol...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Fischer SM,Baldwin JK,Adams LM

    更新日期:1985-09-30 00:00:00

  • Mutual suppression of miR-125a and Lin28b in human hepatocellular carcinoma cells.

    abstract::MicroRNA-125a exhibits an antiproliferative activity and is downregulated in several types of tumors, including hepatocellular carcinoma where it targets sirtuin-7, matrix metalloproteinase-11, and c-Raf. Another target of miR-125a is Lin28, a pluripotency factor that is generally undetectable in differentiated cells ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Panella M,Mosca N,Di Palo A,Potenza N,Russo A

    更新日期:2018-06-07 00:00:00

  • Atrial natriuretic peptide, ANP(99-126), receptors in rat thymocytes and spleen cells.

    abstract::A single class of saturable, specific binding sites for the circulating form of atrial natriuretic peptides, ANP(99-126), was identified in rat thymus and spleen and in isolated thymocytes and spleen cells using quantitative autoradiographic techniques. In the thymus, the relative potency of ANP analogs to inhibit [12...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Kurihara M,Katamine S,Saavedra JM

    更新日期:1987-06-15 00:00:00

  • TopBP1 associates with NBS1 and is involved in homologous recombination repair.

    abstract::TopBP1 is involved in DNA replication and DNA damage checkpoint. Recent studies have demonstrated that TopBP1 is a direct positive effecter of ATR. However, it is not known how TopBP1 recognizes damaged DNA. Here, we show that TopBP1 formed nuclear foci after exposure to ionizing radiation, but such TopBP1 foci were a...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Morishima K,Sakamoto S,Kobayashi J,Izumi H,Suda T,Matsumoto Y,Tauchi H,Ide H,Komatsu K,Matsuura S

    更新日期:2007-11-03 00:00:00

  • Site directed mutagenesis of two cysteine residues in the E. coli ogt O6-alkylguanine DNA alkyltransferase protein.

    abstract::The E. coli ogt O6-alkylguanine-DNA alkyltransferase has two cysteine residues positioned identically with respect to cysteines in the E. coli ada O6-alkylguanine-DNA alkyltransferase. In order to assess their function, these residues were each substituted by a glycine to generate altered forms of the ogt protein. Mut...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Harris LC,Potter PM,Margison GP

    更新日期:1992-08-31 00:00:00

  • Recombinant adenovirus infection suppresses hTERT expression through virus-associated RNA-mediated induction of type 1 interferon.

    abstract::Adenovirus vector is one of the most widely used vectors in gene therapy applications for the treatment of diverse human diseases including cancer. In this study, we showed that infection with E1E3-deleted recombinant human adenovirus serotype 5 reduced human telomerase reverse transcriptase (hTERT) mRNA levels in hep...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Lee CH,Kim HW,Kim T,Lee SW

    更新日期:2015-03-20 00:00:00

  • Isolation of silicate ionophore(s) from the apochlorotic diatom Nitzschia alba.

    abstract::An organic extract of Nitzschia alba cells possesses ionophoretic activity towards silicate, as it induces silicate transport across an organic phase or across synthetic lipid membranes. The activity is dependent upon Na+ and prefers silicon to germanium, a congener. The activity can be resolved into two apparently pu...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Bhattacharyya P,Volcani BE

    更新日期:1983-07-18 00:00:00

  • Electron microscopy and in vitro deneddylation reveal similar architectures and biochemistry of isolated human and Flag-mouse COP9 signalosome complexes.

    abstract::The COP9 signalosome (CSN) is a regulator of the ubiquitin (Ub) proteasome system (UPS). In the UPS, proteins are Ub-labeled for degradation by Ub ligases conferring substrate specificity. The CSN controls a large family of Ub ligases called cullin-RING ligases (CRLs), which ubiquitinate cell cycle regulators, transcr...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Rockel B,Schmaler T,Huang X,Dubiel W

    更新日期:2014-07-25 00:00:00

  • Polymorphic and differential expression of the Trypanosoma cruzi alleles containing universal minicircle binding protein.

    abstract::DNA replication mechanisms are poorly understood in most of trypanosomatids, in particular the replication of the peculiar mitochondrial DNA, the kinetoplast DNA (kDNA). To contribute to the knowledge on the mechanism of kDNA replication in Trypanosoma cruzi, we have previously characterized the Universal Minicircle S...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Coelho ER,Rodrigues Dde C,Urményi TP,Rondinelli E,Silva R

    更新日期:2006-03-10 00:00:00

  • Oligomerization of the transmembrane domain of IRE1α in SDS micelles.

    abstract::IRE1α (Inositol-requiring enzyme 1 α), an endoplasmic reticulum (ER)-resident sensor for mammalian unfolded protein response, is a type I transmembrane protein which has a bifunctional enzyme containing kinase and RNase domains. Although the luminal domain and cytosolic domain of IRE1α are thought to play crucial role...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Cho H,Lamarca R,Chan C

    更新日期:2012-11-02 00:00:00

  • Residue Glu83 plays a major role in negatively regulating alpha-synuclein amyloid formation.

    abstract::Alpha-synuclein (alpha-syn) amyloid filaments are the major ultrastructural component of pathological inclusions that define several neurodegenerative disorders, including Parkinson disease and other disorders that are collectively termed synucleinopathies. Since the aggregation of alpha-syn is associated with the eti...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Waxman EA,Emmer KL,Giasson BI

    更新日期:2010-01-15 00:00:00