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Overexpression of prothymosin alpha, concomitant with c-myc, during rat hepatic carcinogenesis.

Abstract：

:By using a subtraction-enhanced display technique, we identified a cDNA clone representing alpha-prothymosin, from rat hepatocellular carcinoma (HCC). alpha-Prothymosin has been reported to be involved in cell proliferation and regulated by c-myc gene in vitro. In the present study, we investigated the gene expression pattern of alpha-prothymosin and analyzed its correlation with c-myc during rat hepatic carcinogenesis and liver regeneration. Hepatic alpha-prothymosin mRNA levels, concomitant with c-myc, were increased at the early stage of hepatic carcinogenesis (6 weeks), and remained nearly 10 fold higher as the tumor progressed. In comparison, alpha-prothymosin mRNA levels were only slightly and moderately increased at early (3-6 hr) and at later stage (24-30 hr) of liver regeneration after 70% partial hepatectomy. In situ hybridization revealed that overexpressed alpha-prothymosin mRNA was restricted to the tumor nodules and to tumor cells invading blood vessels. These data provide evidence that overexpression of alpha-prothymosin, concomitant with c-myc, is related to rat hepatic carcinogenesis.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Wu CG,Boers W,Reitsma PR,van Deventer SJ,Chamuleau RA

doi

10.1006/bbrc.1997.6377

subject

Has Abstract

pub_date

1997-03-27 00:00:00

pages

817-21

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(97)96377-4

journal_volume

232

pub_type

杂志文章

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