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Leptin enhances CC-chemokine ligand expression in cultured murine macrophage.

Abstract：

:Despite accumulating evidence, the role of leptin in chemokine expression is poorly understood. In this study, we evaluated the effects of leptin on CC-chemokine ligands (CCLs), CCL3, CCL4, and CCL5 gene expression in cultured murine macrophage, J774A.1 cells. Expression of all these CCLs mRNA was gradually increased and significant up-regulation was observed for 3-12 h exposure to leptin (1 microM). The phosphorylated signal transducer and activator of transcription 3 (pSTAT3) was significantly increased for 5-20 min exposure to leptin, and it was localized in leptin receptor-positive macrophage. Pretreatment with AG490 (100 microM), a janus kinase 2 (JAK2) inhibitor, significantly suppressed leptin-induced pSTAT3 increases and the up-regulation of CCLs mRNA expression. In conclusion, leptin enhances CCLs expression in cultured murine macrophage, through activation of a JAK2-STAT3 pathway. Therefore, a new paradigm of leptin-mediated chemokine expression may lead to the clarification of complex immune systems in future.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Kiguchi N,Maeda T,Kobayashi Y,Fukazawa Y,Kishioka S

doi

10.1016/j.bbrc.2009.04.121

subject

Has Abstract

pub_date

2009-07-03 00:00:00

pages

311-5

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(09)00826-2

journal_volume

384

pub_type

杂志文章

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