Functional reconstitution of rat liver cytochrome P-450 with mesohemin.

abstract：:Kallikrein 7 (hK7), a chymostatin-like serine protease, is overexpressed in pancreatic adenocarcinomas as well as other human cancers. Although it has been demonstrated to participate in normal desquamation by facilitating cell shedding at the skin surface, its role in human malignancies remains unclear. To investigat...

journal_title：Biochemical and biophysical research communications

authors： Ramani VC,Haun RS

更新日期：2008-05-16 00:00:00

abstract：:AMP-activated protein kinase (AMPK) plays a key role in maintaining intracellular and whole-body energy homeostasis. Activation of AMPK has been shown to ameliorate the symptoms of metabolic diseases, such as type 2 diabetes and obesity. Here we show that gambogic acid (GB), a known antitumor agent, activates AMPK by ...

journal_title：Biochemical and biophysical research communications

authors： Zhao B,Shen H,Zhang L,Shen Y

更新日期：2012-07-20 00:00:00

abstract：:Malignant human glioma D-298 MG amplifies a rearranged epidermal growth factor receptor (EGFR) gene (c-erbB proto-oncogene), resulting in an in-frame deletion of 83 amino acids in domain IV of the extracellular domain of the EGFR. EGF and transforming growth factor-a (TGF-a) bound to the mutant EGFR with high affinity...

journal_title：Biochemical and biophysical research communications

authors： Humphrey PA,Gangarosa LM,Wong AJ,Archer GE,Lund-Johansen M,Bjerkvig R,Laerum OD,Friedman HS,Bigner DD

更新日期：1991-08-15 00:00:00

abstract：:A rat transplantable pituitary tumor, MtT/F84, grows much faster in E2 treated rats than in normal females, but is much retarded in thyroidectomized rats. Triiodothyronine (T3) administration in a drinking water increased the tumor growth by the dose dependent manner. The tumor contained both estrogen receptor (ER) an...

journal_title：Biochemical and biophysical research communications

authors： Fujimoto N,Roy B,Watanabe H,Ito A

更新日期：1988-04-15 00:00:00

abstract：:Sepiapterin reductase (SPR) is an enzyme that acts in the third and final step of tetrahydrobiopterin (BH4) biosynthesis. The human Spr gene locates within the region of 2.5MB mapped to PARK3, an autosomal dominant form of familial Parkinson's diseases. In order to explore the role of SPR in the metabolism of BH4, we ...

journal_title：Biochemical and biophysical research communications

authors： Takazawa C,Fujimoto K,Homma D,Sumi-Ichinose C,Nomura T,Ichinose H,Katoh S

更新日期：2008-03-21 00:00:00

abstract：:Acute promyelocytic leukemia (APL) is characterized by the presence of the PML-RARα fusion protein. We have previously found that PML-RARα-regulated miR-125b is highly expressed in APL; however, the characteristics of the regulatory effects and mechanisms of miR-125b involved in APL proliferation have yet to be clarif...

journal_title：Biochemical and biophysical research communications

authors： Zhang Y,Zeng C,Lu S,Qin T,Yang L,Chen S,Chen J,Li Y

更新日期：2016-09-30 00:00:00

abstract：:Alpha-bulnesene is a sesquiterpenoid isolated from the water extract of Pogostemon cablin. It showed a potent and concentration-dependent inhibitory effect on platelet-activating factor (PAF) and arachidonic acid (AA) induced rabbit platelet aggregation. In a radioligand binding assay for the PAF receptor, alpha-bulne...

journal_title：Biochemical and biophysical research communications

authors： Hsu HC,Yang WC,Tsai WJ,Chen CC,Huang HY,Tsai YC

更新日期：2006-07-07 00:00:00

abstract：:X chromosome inactivation in mammalian females occurs early in embryonic development and renders most genes on the inactive X chromosome transcriptionally silenced. As a consequence, females will display an X chromosomal parent-of-origin mosaiscism with regard to which parental allele that is expressed. Some genes, ho...

journal_title：Biochemical and biophysical research communications

authors： Nordquist N,Oreland L

更新日期：2006-09-22 00:00:00

abstract：:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) brings about a wide spectrum of toxic and biochemical changes, most of which are mediated by the AH receptor (AHR). Recent cloning of the AHR from the two most TCDD-resistant laboratory animals, Han/Wistar (Kuopio) rats and hamsters, suggested a critical role for the C-termin...

journal_title：Biochemical and biophysical research communications

authors： Korkalainen M,Tuomisto J,Pohjanvirta R

更新日期：2001-08-03 00:00:00

abstract：:8-Hydroxyguanine (8-OH-Gua) residues were formed in DNA of Ehrlich ascites cells exposed to the carcinogen 4-nitroquinoline 1-oxide. Formation of 8-OH-Gua was confirmed by chemical treatment of calf thymus DNA with the proximate metabolite of this carcinogen, 4-hydroxyaminoquinoline 1-oxide, together with seryl-adenos...

journal_title：Biochemical and biophysical research communications

authors： Kohda K,Tada M,Kasai H,Nishimura S,Kawazoe Y

更新日期：1986-09-14 00:00:00

abstract：:Recently, Bmi1 was shown to control the proliferation and self-renewal of neural stem cells (NSCs). In this study, we demonstrated the induction of NSC-like cells (NSCLCs) from mouse astrocytes by Bmi1 under NSC culture conditions. These NSCLCs exhibited the morphology and growth properties of NSCs, and expressed NSC ...

journal_title：Biochemical and biophysical research communications

authors： Moon JH,Yoon BS,Kim B,Park G,Jung HY,Maeng I,Jun EK,Yoo SJ,Kim A,Oh S,Whang KY,Kim H,Kim DW,Kim KD,You S

更新日期：2008-06-27 00:00:00

abstract：:Computing the ligand-protein binding affinity (or the Gibbs free energy) with chemical accuracy has long been a challenge for which many methods/approaches have been developed and refined with various successful applications. False positives and, even more harmful, false negatives have been and still are a common occu...

journal_title：Biochemical and biophysical research communications

authors： Villarreal OD,Yu L,Rodriguez RA,Chen LY

更新日期：2017-01-29 00:00:00

abstract：:A study was made of the effects of the venom of the Chilean spider Latrodectus mactans on endogenous ion-currents of Xenopus laevis oocytes. 1 microg/ml of the venom made the resting plasma membrane potential more negative in cells voltage-clamped at -60 mV. The effect was potentially due to the closure of one or seve...

journal_title：Biochemical and biophysical research communications

authors： Parodi J,Romero F,Miledi R,Martínez-Torres A

更新日期：2008-10-31 00:00:00

abstract：:Osteoblasts mediate much of the hormonal responsiveness of osteoclasts. We and others have found that one mechanism through which this regulation is effected is by release of osteoclast resorption-stimulating activity (ORSA) into culture supernatants. However, although hormonal responsiveness is regularly observed in ...

journal_title：Biochemical and biophysical research communications

authors： Fuller K,Gallagher AC,Chambers TJ

更新日期：1991-11-27 00:00:00

abstract：:We have previously demonstrated that homeodomain proteins, MEIS1 and PBXs, transactivate the PF4 gene through the novel regulatory element termed TME. This study focuses on Pbx regulating protein 1 (PREP1), a MEIS1 homolog protein, for its transcriptional activity in the PF4 promoter. PREP1 binds to the TME in HEL cel...

journal_title：Biochemical and biophysical research communications

authors： Okada Y,Matsuura E,Nagai R,Sato T,Watanabe A,Morita I,Doi T

更新日期：2003-05-23 00:00:00

abstract：:In order to investigate tooth development, several cell lines of the dental epithelium and ectomesenchyme have been established. However, no attempt has been reported to regenerate teeth with cell lines. Here, we have established several clonal cell lines of the dental epithelium from a p53-deficient fetal mouse. They...

journal_title：Biochemical and biophysical research communications

authors： Komine A,Suenaga M,Nakao K,Tsuji T,Tomooka Y

更新日期：2007-04-13 00:00:00

abstract：:The current studies were designed to explore the effects of C-receptor-binding atrial natriuretic peptide analogues on serum-induced mitogenesis in cultured rat aortic smooth muscle cells. To this end, rANF99-126 and a series of truncated (rANF103-126, rANF103-125), ring-deleted (des[Gln116, Ser117, Gly118, Leu119, Gl...

journal_title：Biochemical and biophysical research communications

authors： Cahill PA,Hassid A

更新日期：1991-09-30 00:00:00

abstract：:Store-operated Ca(2+) entry (SOCE) is crucial for various physiological responses in immune cells. Although it is known that STIM1 relocates into discrete puncta juxtaposed to the plasma membrane to initiate SOCE, the machinery modulating the function of STIM1 remains unclear. We explored to find its modulators using ...

journal_title：Biochemical and biophysical research communications

authors： Fujii Y,Shiota M,Ohkawa Y,Baba A,Wanibuchi H,Kinashi T,Kurosaki T,Baba Y

更新日期：2012-06-15 00:00:00

abstract：:Up to now, all reported Ca(2+)-regulated photoproteins, except for mnemiopsin, have been cloned and expressed in Escherichia coli. In this study, the cDNA for an isotype of mnemiopsin, from the ctenophore Mnemiopsis leidyi, has been cloned, sequenced, and functionally expressed. The full length cDNA encoding mnemiopsi...

journal_title：Biochemical and biophysical research communications

authors： Jafarian V,Sariri R,Hosseinkhani S,Aghamaali MR,Sajedi RH,Taghdir M,Hassannia S

更新日期：2011-09-23 00:00:00

abstract：:A melanin (melanosome) concentrating hormone, MCH, was synthesized and the methodology for its synthesis is detailed. This heptadecapeptide, H-Asp-Thr-Met-Arg-Cys-Met-Val-Gly-Arg-Val-Tyr-Arg-Pro-Cys-Trp-Glu-Val-OH , stimulated melanosome concentration (centripetal aggregation) within melanophores of all species of tel...

journal_title：Biochemical and biophysical research communications

authors： Wilkes BC,Hruby VJ,Sherbrooke WC,Castrucci AM,Hadley ME

更新日期：1984-07-31 00:00:00

abstract：:Glutamate-gated chloride (GluCl) channels are pentameric receptors for the inhibitory neurotransmitter glutamate in invertebrates and are a major target for macrolide anthelmintics. Three amino acids in GluCl channels are reported to render macrolide resistance in nematodes and insects. To examine whether these three ...

journal_title：Biochemical and biophysical research communications

authors： Yamaguchi M,Sawa Y,Matsuda K,Ozoe F,Ozoe Y

更新日期：2012-03-16 00:00:00

abstract：:Metallosphaera sedula is a thermoacidophilic autotrophic archaeon and known to utilize the 3-hydroxypropionate/4-hydroxybutyrate cycle (3-HP/4-HB cycle) as a carbon fixation pathway. The 3-HP/4-HB cycle in M. sedula is associated with central metabolism, and malate dehydrogenase (MDH) is an enzyme involved in the cent...

journal_title：Biochemical and biophysical research communications

authors： Lee D,Hong J,Kim KJ

更新日期：2019-02-12 00:00:00

abstract：:It has been suggested that the positive inotropic effect of the vasoactive peptide hormone, endothelin-1 (ET-1), involves inhibition of cardiac K(+) currents. In order to identify the K(+) currents modulated by ET-1, the outward K(+) currents of isolated rat ventricular myocytes were investigated using whole-cell patc...

journal_title：Biochemical and biophysical research communications

authors： James AF,Ramsey JE,Reynolds AM,Hendry BM,Shattock MJ

更新日期：2001-06-22 00:00:00

abstract：:A phosphoprotein with associated tyrosine kinase activity has been purified from a 26,000 x g particulate fraction of rat spleen. The molecular weight of the native kinase is 85-90 kDa as estimated by gel permeation chromatography on Superdex 200 while SDS/PAGE of an autophosphorylated sample indicated a single 28-kDa...

journal_title：Biochemical and biophysical research communications

authors： Borowski P,Medem S,Laufs R

更新日期：1993-07-30 00:00:00

abstract：:The post-transcriptional regulation of gene expression plays an important role in many essential biological processes. The RNA decapping enzyme Dcp2 is a crucial enzyme involved in RNA degradation. Dcp2 proteins are highly expressed in the testis and brain in adult mice. This study aimed to investigate the in vivo fun...

journal_title：Biochemical and biophysical research communications

authors： Li RM,Zhang MN,Tang QY,Song MG

更新日期：2020-05-28 00:00:00

abstract：:Oxidative stress is involved in a multitude of pathological conditions. In the present study, cell cycle arrest was demonstrated in monolayer cultures of Chinese hamster ovary cells subjected to low-level oxidative stress induced by the addition of hydrogen peroxide. Fluorescence-activated cell sorting analysis charac...

journal_title：Biochemical and biophysical research communications

authors： Clopton DA,Saltman P

更新日期：1995-05-05 00:00:00

abstract：:Female Wistar rats were fed on a high fat diet for 18 weeks, during which their energy intake increased by 25% and body weight by 50% due to a doubling of adipose tissue tissue stores. Animals were then treated with increasing doses of a sheep polyclonal antiserum to rat adipocytes on days 1-4 and 7 after which they r...

journal_title：Biochemical and biophysical research communications

authors： Flint DJ

更新日期：1998-11-09 00:00:00

abstract：:Interleukin (IL)-18 bioactivity and dsRNA sensing by receptors of innate immunity are key components of anti-viral host defense. Despite extensive data on signal transduction activated by both pathways knowledge on cross-communication is incomplete. By using human PBMC and predendritic KG1 cells, as prototypic IL-18-r...

journal_title：Biochemical and biophysical research communications

authors： Balah A,Akool el-S,Bachmann M,Pfeilschifter J,Mühl H

更新日期：2009-11-27 00:00:00

abstract：:The most recently described region of alternate splicing of fibronectin mRNA results in expression of an isoform which includes the type III repeat termed ED B (EIII B). To date this isoform has been detected in transformed cells in culture, in the synovial membrane and ovary but in no other adult tissue, and in embry...

journal_title：Biochemical and biophysical research communications

authors： Burton-Wurster N,Lust G,Wert R

更新日期：1989-12-15 00:00:00

abstract：:The effects of endothelins (ETs) on the production of stromelysins, a sub-family of matrix metalloproteinases, were examined in cultured astrocytes. The treatment of cultured rat astrocytes with ET-1 increased stromelysin-1 mRNA levels, while stromelysin-2 and -3 mRNAs were not affected. Immunocytochemical observation...

journal_title：Biochemical and biophysical research communications

authors： Koyama Y,Tanaka K

更新日期：2008-07-11 00:00:00