当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Some effects of the venom of the Chilean spider Latrodectus mactans on endogenous ion-currents of Xenopus laevis oocytes.

Some effects of the venom of the Chilean spider Latrodectus mactans on endogenous ion-currents of Xenopus laevis oocytes.

Abstract：

:A study was made of the effects of the venom of the Chilean spider Latrodectus mactans on endogenous ion-currents of Xenopus laevis oocytes. 1 microg/ml of the venom made the resting plasma membrane potential more negative in cells voltage-clamped at -60 mV. The effect was potentially due to the closure of one or several conductances that were investigated further. Thus, we determined the effects of the venom on the following endogenous ionic-currents: (a) voltage-activated potassium currents, (b) voltage-activated chloride-currents, and (c) calcium-dependent chloride-currents (Tout). The results suggest that the venom exerts its action mainly on a transient outward potassium-current that is probably mediated by a Kv channel homologous to shaker. Consistent with the electrophysiological evidence we detected the expression of the mRNA coding for xKv1.1 in the oocytes.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Parodi J,Romero F,Miledi R,Martínez-Torres A

doi

10.1016/j.bbrc.2008.08.070

subject

Has Abstract

pub_date

2008-10-31 00:00:00

pages

571-5

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(08)01582-9

journal_volume

375

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Effects of oxysterols on the blood-brain barrier: implications for Alzheimer's disease.

    abstract：:Altered brain cholesterol homeostasis plays a key role in neurodegenerative diseases such as Alzheimer's disease (AD). For a long time, the blood-brain barrier (BBB) was basically considered as a barrier isolating the brain from circulating cholesterol, however, several lines of evidence now suggest that the BBB stric...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章,评审

    doi：10.1016/j.bbrc.2013.11.059

    authors： Gosselet F,Saint-Pol J,Fenart L

    更新日期：2014-04-11 00:00:00

  • The conformation formed by the domain after alanine-155 induces inversion of aspartic acid-151 in alpha A-crystallin from aged human lenses.

    abstract：:A new cleavage site, which is a post-translational modification, was found between residues His-154 and Ala-155 in alpha A-crystallin from the aged human lens. After trypsin digestion of alpha A-crystallin two peptides that include Asp-151 were obtained and have remarkable differences. That is, the stereo-configuratio...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1997.7365

    authors： Fujii N,Momose Y,Yamasaki M,Yamagaki T,Nakanishi H,Uemura T,Takita M,Ishii N

    更新日期：1997-10-29 00:00:00

  • A comparison of the antiviral agents 2'-nor-2'-deoxyguanosine and acyclovir: uptake and phosphorylation in tissue culture and kinetics of in vitro inhibition of viral and cellular DNA polymerases by their respective triphosphates.

    abstract：:A comparative study was conducted between the antiherpetic agents 2'-nor-2'-deoxyguanosine (2'NDG) and acyclovir (ACV) with respect to 1) the relative rates of uptake and phosphorylation to the "active" triphosphate species in tissue culture and 2) the in vitro inhibition of viral and cellular DNA polymerases by their...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(83)90530-2

    authors： Germershausen J,Bostedor R,Field AK,Perry H,Liou R,Bull H,Tolman RL,Karkas JD

    更新日期：1983-10-31 00:00:00

  • Effect of retinoic acid on the acylation of phospholipids in granulocytes in vitro.

    abstract：:The influence of retinoic acid on the incorporation of [1-14C]palmitic acid and [1-14C]arachidonic acid into phospholipids was examined in guinea pig peritoneal granulocytes. All-trans-retinoic acid inhibited the incorporation of both fatty acids into phosphatidic acid and phosphatidylinositol. However, it stimulated ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(83)91622-4

    authors： Tou J

    更新日期：1983-07-18 00:00:00

  • Adenosine induces apoptosis through TNFR1/RIPK1/P38 axis in colon cancer cells.

    abstract：:Adenosine, a metabolite of ATP, ubiquitously exists in a wide range of organs and tissues. We previously reported that adenosine was implicated in apoptosis in many cancer cells by extrinsic and/or intrinsic pathways. Here, we found that adenosine suppresses the cell growth by induction of apoptosis of human colonic c...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.03.103

    authors： Yu S,Hou D,Chen P,Zhang Q,Lv B,Ma Y,Liu F,Liu H,Song EJ,Yang D,Liu J

    更新日期：2015-05-08 00:00:00

  • Characterization in vitro and in vivo of hammerhead ribozymes directed against murine tumor necrosis factoralpha.

    abstract：:A hammerhead ribozyme directed against murine TNFalpha (mTNFalpha) mRNA has been constructed. In vitro studies showed that this ribozyme was released from the parent molecule by flanking cis-acting hammerhead and hairpin ribozymes. This same anti-mTNFalpha ribozyme specifically cleaved both synthetically derived subst...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.0927

    authors： MacKay SL,Tannahill CL,Auffenberg T,Ksontini R,Copeland EM 3rd,Moldawer LL

    更新日期：1999-07-05 00:00:00

  • A novel cantharidin analog N-benzylcantharidinamide reduces the expression of MMP-9 and invasive potentials of Hep3B via inhibiting cytosolic translocation of HuR.

    abstract：:Invasion and metastasis are major causes of malignant tumor-associated mortality. The present study aimed to investigate the molecular events underlying inhibitory effect of N-benzylcantharidinamide, a novel synthetic analog of cantharidin, on matrix metalloproteinase-9 (MMP-9)-mediated invasion in highly metastatic h...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.04.035

    authors： Lee JY,Chung TW,Choi HJ,Lee CH,Eun JS,Han YT,Choi JY,Kim SY,Han CW,Jeong HS,Ha KT

    更新日期：2014-05-02 00:00:00

  • Both the PH domain and N-terminal region of oxysterol-binding protein related protein 8S are required for localization to PM-ER contact sites.

    abstract：:Oxysterol-binding protein-related proteins are implicated in the sensing and transporting lipids at the membrane contact sites. One of the members of the mammalian ORP family, ORP8, is thought to transport lipids through directly tethering both ER and PM membranes. Targeting to PM is thought to be mediated by N-termin...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.01.138

    authors： Lee M,Fairn GD

    更新日期：2018-02-19 00:00:00

  • An alpha-subunit loop structure is required for GM2 activator protein binding by beta-hexosaminidase A.

    abstract：:The alpha- and/or beta-subunits of human beta-hexosaminidase A (alphabeta) and B (betabeta) are approximately 60% identical. In vivo only beta-hexosaminidase A can utilize GM2 ganglioside as a substrate, but requires the GM2 activator protein to bind GM2 ganglioside and then interact with the enzyme, placing the termi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.09.159

    authors： Zarghooni M,Bukovac S,Tropak M,Callahan J,Mahuran D

    更新日期：2004-11-19 00:00:00

  • Lumican-null mice are susceptible to aging and isoproterenol-induced myocardial fibrosis.

    abstract：:With aging and stress, the myocardium undergoes structural remodeling, often leading to fibrosis. The purpose of this study is to examine whether lumican, one of the class II small leucine-rich proteoglycans, has a protective role in cardiac remodeling and fibrosis. In attempts to elucidate the hypothesis that lumican...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.12.033

    authors： Chen SW,Tung YC,Jung SM,Chu Y,Lin PJ,Kao WW,Chu PH

    更新日期：2017-01-22 00:00:00

  • Conformational effect of phosphorylation on T cell receptor/CD3 zeta-chain sequences.

    abstract：:The effect of tyrosine-phosphorylation on the conformation of three tyrosine-based immunoreceptor activation motifs, zeta(69-86), zeta(106-126), and zeta(138-155), located in the T cell receptor/CD3 zeta-chain was investigated. Circular dichroism and Fourier-transform infrared spectroscopy of the nonphosphorylated and...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1997.7989

    authors： Laczkó I,Hollósi M,Vass E,Hegedüs Z,Monostori E,Tóth GK

    更新日期：1998-01-26 00:00:00

  • Yeast proteins with reactivity to antibodies elicited against mammalian apolipoproteins.

    abstract：:Hyperimmunized rabbit anti-rat apolipoprotein antibodies showed reactivity to proteins in Saccharomyces cerevisiae. Antiapolipoproteins A1, B and E reacted with proteins in both a crude extract and a lipid enriched fraction. Protein reactivity was dependent on antisera dilution. Furthermore, the different antiapolipop...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(91)91464-n

    authors： Keesler GA,Moore S,Usher DC,Parks LW

    更新日期：1991-01-31 00:00:00

  • The effect of VEGF on blood vessels and blood cells during Xenopus development.

    abstract：:Vascular endothelial growth factor (VEGF) is known to play an essential role in vascular development. We have overexpressed VEGF122 or VEGF170, which are equivalent to mouse VEGF120 and VEGF164, in developing Xenopus embryos. Overexpression of VEGF170 but not VEGF122 demonstrated an absence of expression of hematopoie...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.03.140

    authors： Koibuchi N,Taniyama Y,Nagao K,Ogihara T,Kaneda Y,Morishita R

    更新日期：2006-05-26 00:00:00

  • Protein tyrosine phosphorylation triggered by human Fc gamma RII.

    abstract：:The role of the cytoplasmic domain of human Fc gamma RII in cellular activation was studied by transfecting P815 cells with different isoforms or deletion mutants of this receptor and then assaying protein tyrosine phosphorylation after crosslinking with anti-CD32 monoclonal antibodies. Fc gamma RIIa, but not Fc gamma...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.1775

    authors： Liu Z,Pudiak D,Looney RJ

    更新日期：1994-06-15 00:00:00

  • Identification of brain-specific angiogenesis inhibitor 2 as an interaction partner of glutaminase interacting protein.

    abstract：:The vast majority of physiological processes in living cells are mediated by protein-protein interactions often specified by particular protein sequence motifs. PDZ domains, composed of 80-100 amino acid residues, are an important class of interaction motif. Among the PDZ-containing proteins, glutaminase interacting p...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.07.029

    authors： Zencir S,Ovee M,Dobson MJ,Banerjee M,Topcu Z,Mohanty S

    更新日期：2011-08-12 00:00:00

  • The heat shock response inhibits inducible nitric oxide synthase gene expression by blocking I kappa-B degradation and NF-kappa B nuclear translocation.

    abstract：:We investigated the mechanisms by which the heat shock response inhibits inducible nitric oxide synthase (iNOS) gene expression. Incubation of cultured murine lung epithelium (MLE-15) at temperatures ranging from 39 to 43 degrees C, for 1 h, demonstrated that only severe thermal stress (41 to 43 degrees C) was suffici...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1997.6076

    authors： Wong HR,Ryan M,Wispé JR

    更新日期：1997-02-13 00:00:00

  • Beta-catenin control of T-cell transcription factor 4 (Tcf4) importation from the cytoplasm to the nucleus contributes to Tcf4-mediated transcription in 293 cells.

    abstract：:Beta-catenin has essential roles in morphogenesis and human cancer, both as a subunit of adhesive complexes in the cell membrane and as a transcriptional coactivator in the Wnt signaling pathway. In addition, beta-catenin also has the ability to transport lymphoid enhancer binding factor-1 into the nucleus. In this st...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.02.193

    authors： Hsu HT,Liu PC,Ku SY,Jung KC,Hong YR,Kao C,Wang C

    更新日期：2006-05-12 00:00:00

  • Unprocessed barley aleurone endo-beta-1,4-xylanase X-I is an active enzyme.

    abstract：:Endo-beta-1,4-xylanase X-I is a major hydrolase produced by the aleurone tissue of germinating barley grain. It was previously reported that this cytosolic enzyme is synthesized as an inactive precursor which is proteolytically processed to active forms upon its programmed cell death dependent release. We here demonst...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.03.066

    authors： Van Campenhout S,Pollet A,Bourgois TM,Rombouts S,Beaugrand J,Gebruers K,De Backer E,Courtin CM,Delcour JA,Volckaert G

    更新日期：2007-05-11 00:00:00

  • Mice lacking Smad3 are protected against streptozotocin-induced diabetic glomerulopathy.

    abstract：:Transforming growth factor-beta (TGF-beta) has been implicated in the development of diabetic glomerulopathy. In order to evaluate a role of Smad3, one of the major signaling molecules downstream of TGF-beta, in the pathogenesis of diabetic glomerulopathy, Smad3-null mice were made diabetic with streptozotocin injecti...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(03)00885-4

    authors： Fujimoto M,Maezawa Y,Yokote K,Joh K,Kobayashi K,Kawamura H,Nishimura M,Roberts AB,Saito Y,Mori S

    更新日期：2003-06-13 00:00:00

  • Interleukin-6 negatively regulates the expression of pregnane X receptor and constitutively activated receptor in primary human hepatocytes.

    abstract：:The marked impairment of hepatic drug metabolism during inflammation and infections has been known for many years and shown to result from down-regulation of cytochrome P450s (CYP) by cytokines. However, the mechanism of this repression is unknown. Using primary cultures of human hepatocytes, we show here that interle...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2000.3219

    authors： Pascussi JM,Gerbal-Chaloin S,Pichard-Garcia L,Daujat M,Fabre JM,Maurel P,Vilarem MJ

    更新日期：2000-08-11 00:00:00

  • Structure-function studies of the epidermal growth factor domains of human thrombomodulin.

    abstract：:Structure-function relationships in the 6 epidermal growth factor-like domains of human thrombomodulin (TME, residues 227-462) were studied by deletion mutagenesis. Purified and characterised proteins were used for kinetic studies. Deletion of EGF1, EGF2 and residues 310-332 in EGF3 had no effect on thrombin binding (...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(92)91662-a

    authors： Parkinson JF,Nagashima M,Kuhn I,Leonard J,Morser J

    更新日期：1992-06-15 00:00:00

  • Comparative studies of polyhemic cytochromes c isolated from Desulfovibrio vulgaris (Hildenborough) and Desulfovibrio desulfuricans (Norway).

    abstract：:Cytochrome c3 (Mr 26,000) has been characterized in Desulfovibrio vulgaris (Hildenborough) and its properties compared with polyhemic cytochromes c isolated from the same organism and from D. desulfuricans (Norway). It can be described as an octaheme cytochrome c3 constituted of two identical subunits. Absorption spec...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(89)90047-8

    authors： Loutfi M,Guerlesquin F,Bianco P,Haladjian J,Bruschi M

    更新日期：1989-03-15 00:00:00

  • Lithium prevents early cytosolic calcium increase and secondary injurious calcium overload in glycolytically inhibited endothelial cells.

    abstract：:Cytosolic free calcium concentration ([Ca(2+)]i) is a central signalling element for the maintenance of endothelial barrier function. Under physiological conditions, it is controlled within narrow limits. Metabolic inhibition during ischemia/reperfusion, however, induces [Ca(2+)]i overload, which results in barrier fa...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.03.047

    authors： Bosche B,Schäfer M,Graf R,Härtel FV,Schäfer U,Noll T

    更新日期：2013-05-03 00:00:00

  • The myosin head can bind two actin monomers.

    abstract：:Force impulse is thought to be generated in muscle when myosin head (S-1), while weakly bound to actin filament, undergoes orientational change to form a strong (rigor) bond with actin. There is ample evidence that this bond involves interaction of 1 myosin head with 1 actin monomer. However, X-ray diffraction data of...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(91)91990-t

    authors： Andreev OA,Borejdo J

    更新日期：1991-05-31 00:00:00

  • Isolation of a keto sugar specific agglutinin from rat uterus.

    abstract：:A ketosugar-specific agglutinin has been identified and purified to apparent homogeneity by affinity chromatography from the three days post-coital rat uterus. This protein is not found in other stages of estrous cycle. The agglutinin is glycoprotein, moves as single band with molecular weight 37,000 in polyacrylamide...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(86)90884-3

    authors： Chowdhury M

    更新日期：1986-04-14 00:00:00

  • Inhibitory effect of 11-carbonyl-beta-boswellic acid on non-small cell lung cancer H446 cells.

    abstract：BACKGROUND:The anti-lung tumor potential of 11-carbonyl-β-boswellic acid was investigated. MATERIALS & METHODS:The inhibitory effects of 11-carbonyl-β-boswellic acid on non-small cell lung cancer (NSCLC) was assessed by proliferation, apoptosis, cell cycle and molecular mechanisms in NSCLC H446 cells in vitro. The res...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.06.137

    authors： Huang G,Yang J,Zhang L,Cao L,Zhang M,Niu X,Zhou Z,Zhang X,Li P,Liu JF

    更新日期：2018-09-18 00:00:00

  • Enhanced SUMOylation in polyglutamine diseases.

    abstract：:Small ubiquitin-like modifiers (SUMOs) are proteins homologous to ubiquitin that possibly regulate intranuclear protein localization, nuclear transport, and ubiquitination. We examined patients of DRPLA, SCA1, MJD, and Huntington's disease and found that neurons in affected regions of the brain react strongly to SUMO-...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/S0006-291X(02)00211-5

    authors： Ueda H,Goto J,Hashida H,Lin X,Oyanagi K,Kawano H,Zoghbi HY,Kanazawa I,Okazawa H

    更新日期：2002-04-26 00:00:00

  • Gamma-interferon counteracts interleukin-1 alpha stimulated expression of urokinase-type plasminogen activator in human endothelial cells in vitro.

    abstract：:The effect of gamma-interferon (gamma-IFN) on the interleukin-1 alpha (IL-1 alpha) induced stimulation of urokinase-type plasminogen activator (u-PA) expression in human foreskin microvascular endothelial cells (HFMEC) and in human umbilical vein endothelial cells (HUVEC) was investigated. When gamma-IFN and IL-1 alph...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(92)92407-o

    authors： Wojta J,Zoellner H,Gallicchio M,Hamilton JA,McGrath K

    更新日期：1992-10-15 00:00:00

  • Structural characterization of BRCT-tetrapeptide binding interactions.

    abstract：:BRCT(BRCA1) plays a major role in DNA repair pathway, and does so by recognizing the conserved sequence pSXXF in its target proteins. Remarkably, tetrapeptides containing pSXXF motif bind with high specificity and micromolar affinity. Here, we have characterized the binding interactions of pSXXF tetrapeptides using NM...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.01.098

    authors： Joseph PR,Yuan Z,Kumar EA,Lokesh GL,Kizhake S,Rajarathnam K,Natarajan A

    更新日期：2010-03-05 00:00:00

  • Differential regulation of dynein-driven melanosome movement.

    abstract：:Cytoplasmic dyneins are multisubunit minus-end-directed microtubule motors. Different isoforms of dynein are thought to provide a means for independent movement of different organelles. We investigated the differential regulation of dynein-driven transport of pigment organelles (melanosomes) in Xenopus melanophores. A...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2003.08.047

    authors： Reilein AR,Serpinskaya AS,Karcher RL,Dujardin DL,Vallee RB,Gelfand VI

    更新日期：2003-09-26 00:00:00