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Identification of miR-125b targets involved in acute promyelocytic leukemia cell proliferation.

Abstract：

:Acute promyelocytic leukemia (APL) is characterized by the presence of the PML-RARα fusion protein. We have previously found that PML-RARα-regulated miR-125b is highly expressed in APL; however, the characteristics of the regulatory effects and mechanisms of miR-125b involved in APL proliferation have yet to be clarified. In this study, we demonstrate that miR-125b promotes the proliferation of APL cells with the involvement of the PI3K/Akt and MAPK signaling pathways. Furthermore, we identified BTG2, MAP3K11, RPS6KA1 and PRDM1 as putative targets of miR-125b, which we verified using luciferase reporter constructs. Moreover, we demonstrate that the expression of miR-125b targets is downregulated in leukemic cells in patients with APL. Thus, our results provide evidence that miR-125b can modulate multiple oncogenic cell proliferation pathways and may be a novel therapeutic target for APL.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Zhang Y,Zeng C,Lu S,Qin T,Yang L,Chen S,Chen J,Li Y

doi

10.1016/j.bbrc.2016.09.020

subject

Has Abstract

pub_date

2016-09-30 00:00:00

pages

1758-63

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(16)31469-3

journal_volume

478

pub_type

杂志文章

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