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The AH receptor of the most dioxin-sensitive species, guinea pig, is highly homologous to the human AH receptor.

Abstract：

:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) brings about a wide spectrum of toxic and biochemical changes, most of which are mediated by the AH receptor (AHR). Recent cloning of the AHR from the two most TCDD-resistant laboratory animals, Han/Wistar (Kuopio) rats and hamsters, suggested a critical role for the C-terminal transactivation domain structure in TCDD sensitivity. Here we cloned the AHR from the most TCDD-susceptible species, guinea pig. The N-terminus of its AHR was highly similar to that in the resistant animals. However, the C-terminal Q-rich subdomain was only about half the size of this subunit in the hamster AHR. There was a distinct correlation across published mammalian species between the number of glutamine residues in the Q-rich subdomain and sensitivity to the acute lethality of TCDD. The closest homolog of the Guinea pig receptor turned out to be the human AHR, which may be relevant for dioxin risk assessment.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Korkalainen M,Tuomisto J,Pohjanvirta R

doi

10.1006/bbrc.2001.5317

subject

Has Abstract

pub_date

2001-08-03 00:00:00

pages

1121-9

issue

5

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(01)95317-3

journal_volume

285

pub_type

杂志文章

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