Characterization of a second promoter for the mouse liver/bone/kidney-type alkaline phosphatase gene: cell and tissue specific expression.

Abstract:

:The second leader exon and the relative promoter of the mouse liver/bone/kidney-type alkaline phosphatase gene were identified and characterized. The transcription initiation site was determined by S1 mapping analysis. The differential expression of the two alternatively spliced transcripts was assessed in cell lines of different origin and in various tissues by polymerase chain reaction and RNase mapping analysis. The first promoter is active in embryo derived cells, whereas the second promoter is silent in basal conditions but it is activated by dibutyryl cAMP in fibroblastic cells. In the whole animal, the transcript driven by the first promoter is found in most tissues albeit at different levels, while the one driven by the second promoter is specifically expressed at high levels only in the heart.

authors

Studer M,Terao M,Gianni M,Garattini E

doi

10.1016/0006-291x(91)91722-o

subject

Has Abstract

pub_date

1991-09-30 00:00:00

pages

1352-60

issue

3

eissn

0006-291X

issn

1090-2104

pii

0006-291X(91)91722-O

journal_volume

179

pub_type

杂志文章
  • A new feature of angiotensin-converting enzyme in the brain: hydrolysis of substance P.

    abstract::Highly purified rat brain angiotensin-converting enzyme hydrolyzes substance P which contains a C-terminal amino acid with an amidated carboxyl group. The hydrolysis of substance P verified by amino-group fluorometry and by high-performance liquid chromatography is inhibited by captopril, but not by phosphoramidon. Th...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/0006-291x(83)90586-7

    authors: Yokosawa H,Endo S,Ogura Y,Ishii S

    更新日期:1983-10-31 00:00:00

  • Sulfate transport in brush border membrane vesicles prepared from human placental syncytiotrophoblast.

    abstract::Isolated brush-border membrane vesicles prepared from human placenta are known to transport amino acids via a Na+-dependent mechanism akin to that found in gut and kidney vesicle preparations. We studied sulfate transport in placental vesicles and failed to identify any Na+-dependent uptake mechanism. Rather, uptake i...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/0006-291x(84)90402-9

    authors: Cole DE

    更新日期:1984-08-30 00:00:00

  • Homeodomain protein CDX2 regulates COX-2 expression in colorectal cancer.

    abstract::CDX2 is an intestine-specific tumor suppressor gene encoding homeodomain-containing transcription factor, which is involved in a variety of developmental, proliferating, and differentiating processes. Moreover, the expression of CDX2 is reduced in a subset of primary colorectal cancers. In contrast, cyclooxygenase-2 (...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2004.01.020

    authors: Kim SP,Park JW,Lee SH,Lim JH,Jang BC,Lee SH,Jang IH,Freund JN,Suh SI,Mun KC,Song DK,Ha EM,Lee WJ,Kwon TK

    更新日期:2004-02-27 00:00:00

  • Synthetic cyclohexenyl chalcone natural products possess cytotoxic activities against prostate cancer cells and inhibit cysteine cathepsins in vitro.

    abstract::A number of cyclohexenyl chalcone Diels-Alder natural products possess promising biological properties including strong cytotoxicity in various human cancer cells. Herein, we show that natural products in this class including panduratin A and nicolaioidesin C inhibit cysteine cathepsins as indicated by protease profil...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2011.11.052

    authors: Deb Majumdar I,Devanabanda A,Fox B,Schwartzman J,Cong H,Porco JA Jr,Weber HC

    更新日期:2011-12-16 00:00:00

  • Sck interacts with KDR and Flt-1 via its SH2 domain.

    abstract::Vascular endothelial growth factor (VEGF) is one of the major angiogenesis regulators. It binds to its tyrosine kinase receptors, KDR and Flt-1. However, little is known about their downstream signal transduction properties. We screened human brain cDNA library using the yeast two-hybrid system with the KDR cytoplasmi...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1006/bbrc.1998.9442

    authors: Igarashi K,Shigeta K,Isohara T,Yamano T,Uno I

    更新日期:1998-10-09 00:00:00

  • Regulation of pituitary growth hormone-releasing factor (GRF) receptor gene expression by GRF.

    abstract::We examined how growth hormone-releasing factor (GRF) regulated pituitary GRF receptor gene expression in the conscious rat. GRF receptor mRNA levels were significantly increased by immunoneutralization of endogenous GRF with its specific antiserum. This effect was dose dependent and the maximum level was 3.8-fold hig...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1006/bbrc.1996.1068

    authors: Miki N,Ono M,Murata Y,Ohsaki E,Tamitsu K,Yamada M,Demura H

    更新日期:1996-07-16 00:00:00

  • Analysis of self-association of West Nile virus capsid protein and the crucial role played by Trp 69 in homodimerization.

    abstract::The understanding of capsid (C) protein interactions with itself would provide important data on how the core is organized in flaviviruses during assembly. In this study, West Nile (WN) virus C protein was shown to form homodimers using yeast two-hybrid analysis in conjunction with mammalian two-hybrid and in vivo co-...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2005.01.121

    authors: Bhuvanakantham R,Ng ML

    更新日期:2005-04-01 00:00:00

  • A new and rapid method for visualising DNA replication in spread DNA by immunofluorescence detection of incorporated 5-iododeoxyuridine.

    abstract::We have developed a new and rapid immunofluorescent method for visualisation of replicated regions on fixed DNA fibers. Using this method we have found in 5-fluorodeoxyuridine (FrdU)-blocked human cells distinct replication units covering about 60 kb of DNA and corresponding in size to single replicons or chromatin lo...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1006/bbrc.1993.1039

    authors: Tomilin N,Rosanov Yu,Zenin V,Bozhkov V,Vig B

    更新日期:1993-01-15 00:00:00

  • Ten tandem repeats of beta-hCG 109-118 enhance immunogenicity and anti-tumor effects of beta-hCG C-terminal peptide carried by mycobacterial heat-shock protein HSP65.

    abstract::The beta-subunit of human chorionic gonadotropin (beta-hCG) is secreted by many kinds of tumors and it has been used as an ideal target antigen to develop vaccines against tumors. In view of the low immunogenicity of this self-peptide,we designed a method based on isocaudamer technique to repeat tandemly the 10-residu...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2006.05.022

    authors: Yankai Z,Rong Y,Yi H,Wentao L,Rongyue C,Ming Y,Taiming L,Jingjing L,Jie W

    更新日期:2006-07-14 00:00:00

  • Activation of (Na+ + K+)-ATPase induces positive inotropy in intact mouse heart in vivo.

    abstract:OBJECTIVE:We have recently identified an activation site on (Na+ + K+)-ATPase and found that binding of antibody SSA412 to this specific site of the enzyme markedly augments (Na+ + K+)-ATPase catalytic activity. Demonstration of whether activation of (Na+ + K+)-ATPase affects heart function in animal in vivo was the ob...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2006.08.070

    authors: Xu KY,Takimoto E,Fedarko NS

    更新日期:2006-10-20 00:00:00

  • Coordinate upregulation of proteolytic-related genes in rat muscle during late fasting.

    abstract::The present study examines whether and to what extent the profiles of proteolytic-related genes are altered in atrophying muscle during prolonged food deprivation. Long-term fasted animals exhibited three metabolic phases characterized by changes in lipid and protein utilization. Starvation induced an increase in some...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2003.10.091

    authors: Bertile F,Le Maho Y,Raclot T

    更新日期:2003-11-28 00:00:00

  • The unit event of sliding of the chemo-mechanical enzyme composed of myosin and actin with regulatory proteins.

    abstract::Various myosin-actin systems do not always show the same sliding behaviors. To make the situation clear, discussions are concentrated on the unit event of sliding of the chemo-mechanical enzyme composed of a single myosin head and a single actin filament with regulatory proteins. The popular idea of the one-to-one cor...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章,评审

    doi:10.1016/j.bbrc.2007.11.186

    authors: Oosawa F

    更新日期:2008-04-25 00:00:00

  • Glycolysis and lipid synthesis in brown adipose tissue during ageing in the rat.

    abstract::The maximal activity of the enzymes hexokinase and 6-phosphofructokinase were measured in interscapular brown adipose tissue during ageing in the rat. The activity of these glycolytic enzymes increased markedly during the suckling-weaning transition (20-22 days of age), but from 30 to 100 days of age the activities pe...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/0006-291x(86)91107-1

    authors: Simpson ML,Cooney GJ,Caterson ID,Newsholme EA

    更新日期:1986-10-15 00:00:00

  • The association of small heat shock protein Hsp16.3 with the plasma membrane of Mycobacterium tuberculosis: dissociation of oligomers is a prerequisite.

    abstract::Hsp16.3, a small heat shock protein from Mycobacterium tuberculosis (MTB), was originally identified as an immuno-dominant antigen and later found to be a major membrane protein. In vitro studies show that Hsp16.3 exists as nonamers and undergoes dynamic dissociation/re-association equilibrium in solutions. Neverthele...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2005.03.092

    authors: Zhang H,Fu X,Jiao W,Zhang X,Liu C,Chang Z

    更新日期:2005-05-20 00:00:00

  • A novel cantharidin analog N-benzylcantharidinamide reduces the expression of MMP-9 and invasive potentials of Hep3B via inhibiting cytosolic translocation of HuR.

    abstract::Invasion and metastasis are major causes of malignant tumor-associated mortality. The present study aimed to investigate the molecular events underlying inhibitory effect of N-benzylcantharidinamide, a novel synthetic analog of cantharidin, on matrix metalloproteinase-9 (MMP-9)-mediated invasion in highly metastatic h...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2014.04.035

    authors: Lee JY,Chung TW,Choi HJ,Lee CH,Eun JS,Han YT,Choi JY,Kim SY,Han CW,Jeong HS,Ha KT

    更新日期:2014-05-02 00:00:00

  • Appearance of membrane-bound tyrosine kinase during differentiation of HL-60 leukemia cells by immune interferon and tumor necrosis factor.

    abstract::The effect of immune interferon (IFN-gamma) and recombinant tumor necrosis factor (rTNF-alpha) on cellular differentiation was investigated in human promyelocytic leukemia cell line HL-60. Both IFN-gamma and rTNF-alpha induced the appearance of the monocytic phenotype in a dose- and time-dependent manner as assessed b...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/0006-291x(86)90721-7

    authors: Glazer RI,Chapekar MS,Hartman KD,Knode MC

    更新日期:1986-11-14 00:00:00

  • Evaluation of glycated insulin in diabetic animals using immunocytochemistry and radioimmunoassay.

    abstract::Glycated insulin was evaluated in plasma and biological tissues of diabetic animal models by immunocytochemistry (ICC) and a novel radioimmunoassay. Glycated insulin circulated at 0.10 +/- 0.04 ng/ml and 2.20 +/- 0.14 ng/ml in lean and diabetic obese (ob/ob) mice, corresponding to 12.5 and 9.8% total plasma insulin, r...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1006/bbrc.2001.5447

    authors: McKillop AM,Mooney MH,Harriott P,Flatt PR,O'Harte FP

    更新日期:2001-08-24 00:00:00

  • Evaluation of viral and mammalian promoters for driving transgene expression in mouse liver.

    abstract::Fifteen luciferase plasmid constructs driven by various promoters including cytomegalovirus (CMV), Rous sarcoma virus (RSV), human serum albumin (SA), alpha-1 antitrypsin (AAT), cytochrome P450 CYP1A2, CYP2C9, CYP2C18, CYP2D6, CYP3A4, mouse CYP2b10, human amyloid precursor protein (APP), chicken beta actin (ACT), nucl...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2005.11.063

    authors: Al-Dosari M,Zhang G,Knapp JE,Liu D

    更新日期:2006-01-13 00:00:00

  • Depletion of uracil-DNA glycosylase activity is associated with decreased cell proliferation.

    abstract::Uracil-DNA glycosylase (UNG) is the primary enzyme responsible for removing uracil residues from DNA. Increasing evidence suggests that UNG may be a potential target for the development of novel antiviral and/or anticancer agents. To determine whether the uracil-DNA glycosylase inhibitor protein (UGI) could be used to...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2005.06.118

    authors: Studebaker AW,Ariza ME,Williams MV

    更新日期:2005-08-26 00:00:00

  • Effects of antibodies to adipocytes on body weight, food intake, and adipose tissue cellularity in obese rats.

    abstract::Female Wistar rats were fed on a high fat diet for 18 weeks, during which their energy intake increased by 25% and body weight by 50% due to a doubling of adipose tissue tissue stores. Animals were then treated with increasing doses of a sheep polyclonal antiserum to rat adipocytes on days 1-4 and 7 after which they r...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1006/bbrc.1998.9622

    authors: Flint DJ

    更新日期:1998-11-09 00:00:00

  • Kinetic analysis of the binding of guanine nucleotide to bovine brain smg p25A.

    abstract::Bovine brain smg p25A, a guanine nucleotide-binding protein with a Mr of about 25,000, bound specifically GTP, guanosine 5'-(3-O-thio)triphosphate (GTP gamma S) and GDP. The initial velocities of the binding of GTP gamma S to GDP-bound smg p25A and the dissociation of GDP from this protein increased by decreasing Mg2+...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/0006-291x(89)91992-x

    authors: Shoji I,Kikuchi A,Kuroda S,Takai Y

    更新日期:1989-07-14 00:00:00

  • Semicarbazide-sensitive amine oxidase in transgenic mice with diabetes.

    abstract::Semicarbazide-sensitive amine oxidase (SSAO) activity in plasma is increased in diabetes, and in particular, in diabetic patients with vascular complications. It has been speculated that SSAO is involved in the development of such complications due to the production of cytotoxic compounds. In this work, we have induce...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2004.10.140

    authors: Gokturk C,Nordquist J,Sugimoto H,Forsberg-Nilsson K,Nilsson J,Oreland L

    更新日期:2004-12-17 00:00:00

  • Differential subcellular localisation of two isoforms of p70 S6 protein kinase.

    abstract::Ribosomal protein S6 phosphorylation is stimulated by a variety of hormones and growth factors. In mammalian cells the predominant S6 kinase is a 70 kDa enzyme which exists in two forms differing only in their amino terminal region. To determine whether this difference is functionally significant we have examined the ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1006/bbrc.1994.1112

    authors: Coffer PJ,Woodgett JR

    更新日期:1994-01-28 00:00:00

  • Nanomolar concentrations of lysophosphatidylcholine recruit monocytes and induce pro-inflammatory cytokine production in macrophages.

    abstract::Lysophosphatidylcholine (LPC) has been attributed a pro-inflammatory role in atherosclerosis. Cell culture studies have identified stimulation of cytokine expression and chemotaxis by micromolar (muM) concentrations of LPC. In the present study we have investigated if LPC, in similarity with many other lipid mediators...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2008.03.087

    authors: Olofsson KE,Andersson L,Nilsson J,Björkbacka H

    更新日期:2008-05-30 00:00:00

  • The anti-malarial atovaquone selectively increases chemosensitivity in retinoblastoma via mitochondrial dysfunction-dependent oxidative damage and Akt/AMPK/mTOR inhibition.

    abstract::Mitochondria has been identified as a promising target in several cancers. However, little is known on the effects of targeting mitochondria in retinoblastoma. In this work, we show that anti-malarial atovaquone, at clinically achievable concentration, demonstrates inhibitory effects to retinoblastoma cells, to a more...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2018.06.049

    authors: Ke F,Yu J,Chen W,Si X,Li X,Yang F,Liao Y,Zuo Z

    更新日期:2018-10-02 00:00:00

  • Measurement of nitric oxide release in the isolated perfused rat lung.

    abstract::In this study we have continuously measured real-time production of nitric oxide (NO) in the isolated, perfused rat lung by using an NO monitor (model NO-501, Inter Medical Co., Nagoya, Japan) with an NO-selective resin microsensor. A stable NO response was obtained when the sensor was placed in the pulmonary artery o...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1006/bbrc.1995.1435

    authors: Wang D,Hsu K,Hwang CP,Chen HI

    更新日期:1995-03-28 00:00:00

  • Oligomerization of an archaeal group II chaperonin is mediated by N-terminal salt bridges.

    abstract::Group II chaperonins (Cpns) are essential mediators of cellular protein folding in eukaryotes and archaea. They consist of two back-to-back rings forming symmetrical cavities in which non-native substrates undergo appropriate folding, but the primary structural basis for the double ring formation remains unclear. To a...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2011.08.112

    authors: Luo H,Zhang P,Robb FT

    更新日期:2011-09-23 00:00:00

  • Genomic cloning of the human histo-blood group ABO locus.

    abstract::A P1 phage clone containing the near complete protein coding region of the human histo-blood group ABO gene locus was isolated and characterized. The insert was estimated at approximately 41 kp, and an approximately 20 kbp BamHI fragment contained the near complete coding region as evaluated by Southern blot analysis....

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1006/bbrc.1995.1044

    authors: Bennett EP,Steffensen R,Clausen H,Weghuis DO,van Kessel AG

    更新日期:1995-01-05 00:00:00

  • Cisplatin and TNF-alpha downregulate transcription of Bcl-xL in murine malignant mesothelioma cells.

    abstract::Malignant mesothelioma (MM) is an aggressive and highly chemo-resistant tumour. In this study, we examined cisplatin-induced apoptosis in mouse models of this disease and investigated the role of constitutive and inducible expression of apoptosis related genes in this process. All of the four mouse MM cell lines exami...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2005.09.147

    authors: Fox SA,Kusmiaty,Loh SS,Dharmarajan AM,Garlepp MJ

    更新日期:2005-11-25 00:00:00

  • Vanadate stimulates Na+/H+ exchange activity in A431 cells.

    abstract::Recent studies have established that polypeptide growth factors cause an elevation of the cytoplasmic pH (pHi) in cultured mammalian cells by stimulating Na+/H+ exchange. We show that vanadate, previously found to act as a mitogen for a number of cells, reversibly activates Na+/H+ exchange at micromolar concentrations...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/0006-291x(84)91356-1

    authors: Cassel D,Zhuang YX,Glaser L

    更新日期:1984-01-30 00:00:00