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Regulation of acetyl coenzyme-A carboxylase gene in a transgenic animal model.

Abstract：

:The gene for acetyl-CoA carboxylase, the rate-limiting enzyme in the biosynthesis of long-chain fatty acids, contains two promoters; promoter I (PI) and promoter II (PII) which are responsible for generation of class I and class II ACC mRNAs, respectively. Class I ACC mRNAs are present in adipose tissue, but only a trace was found in the liver under normal physiological conditions. However, class I mRNAs were induced under stimulated lipogenic conditions. To investigate how PI is regulated in vivo, we generated transgenic mice containing a reporter gene under the control of PI. In transgenic mice, PI is generally inactive and a small amount of PI activity was found only in the adipose tissues of female animals. Stimulated lipogenic conditions activated PI about 17-fold over normal conditions and again only in white adipose tissues of female animals.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Ekhterae D,Tae HJ,Daniel S,Moller DE,Kim KH

doi

10.1006/bbrc.1996.1543

subject

Has Abstract

pub_date

1996-10-14 00:00:00

pages

547-52

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(96)91543-0

journal_volume

227

pub_type

杂志文章

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