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miR-25 modulates NSCLC cell radio-sensitivity through directly inhibiting BTG2 expression.

Abstract：

:A large proportion of the NSCLC patients were insensitive to radiotherapy, but the exact mechanism is still unclear. This study explored the role of miR-25 in regulating sensitivity of NSCLC cells to ionizing radiation (IR) and its downstream targets. Based on measurement in tumor samples from NSCLC patients, this study found that miR-25 expression is upregulated in both NSCLC and radio-resistant NSCLC patients compared the healthy and radio-sensitive controls. In addition, BTG expression was found negatively correlated with miR-25a expression in the both tissues and cells. By applying luciferase reporter assay, we verified two putative binding sites between miR-25 and BTG2. Therefore, BTG2 is a directly target of miR-25 in NSCLC cancer. By applying loss-and-gain function analysis in NSCLC cell lines, we demonstrated that miR-25-BTG2 axis could directly regulated BTG2 expression and affect radiotherapy sensitivity of NSCLC cells.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

He Z,Liu Y,Xiao B,Qian X

doi

10.1016/j.bbrc.2014.12.094

subject

Has Abstract

pub_date

2015-02-13 00:00:00

pages

235-41

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(14)02283-9

journal_volume

457

pub_type

杂志文章

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