Chondroitin sulfate E blocks enzymatic action of heparanase and heparanase-induced cellular responses.

abstract：:Neurotrophins are essential for the development and survival of catecholaminergic neurons. However, the critical pathway for expression of the tyrosine hydroxylase (TH) gene induced by neurotrophin is still unclear. Here we found that Ras/MEK pathway is required for NGF-induced expression of the TH gene in PC12D cells...

journal_title：Biochemical and biophysical research communications

authors： Suzuki T,Kurahashi H,Ichinose H

更新日期：2004-03-05 00:00:00

abstract：:We investigated the effect of in vivo hypothyroidism on the sialylation and sulfation of thyroid-stimulating hormone (TSH) secreted by mouse pituitary explants. Oligosaccharides from secreted thyroid-stimulating hormone from hypothyroid animals contained greater sialic acid relative to sulfate in both alpha and beta s...

journal_title：Biochemical and biophysical research communications

authors： DeCherney GS,Gesundheit N,Gyves PW,Showalter CR,Weintraub BD

更新日期：1989-03-15 00:00:00

abstract：:By analyzing The Cancer Genome Atlas (TCGA) datasets, we discovered that the zinc finger protein 692 (ZNF692) were over-expressed in Lung adenocarcinoma (LUAD) tissues compared to adjacent non-tumor tissues (P < 0.0001). In this study, we investigated the function of ZNF692 in the progression of LUAD. We found that ZN...

journal_title：Biochemical and biophysical research communications

authors： Zhang Q,Zheng X,Sun Q,Shi R,Wang J,Zhu B,Xu L,Zhang G,Ren B

更新日期：2017-09-02 00:00:00

abstract：:Patient-derived xenografts (PDXs) are widely recognised as a more physiologically relevant preclinical model than standard cell lines, but are expensive and low throughput, have low engraftment rate and take a long time to develop. Our newly developed conditional reprogramming (CR) technology addresses many PDX drawba...

journal_title：Biochemical and biophysical research communications

authors： Mondal AM,Ma AH,Li G,Krawczyk E,Yuan R,Lu J,Schlegel R,Stamatakis L,Kowalczyk KJ,Philips GK,Pan CX,Liu X

更新日期：2019-09-10 00:00:00

abstract：:Glial glutamate transporter GLT-1 mRNA was selectively induced in C6 glioma cells exposed to hypertonic stress (HS), while the expression of two other subtypes, GLAST and EAAC1, was suppressed. HS increased phosphorylation of the MAPK family, ERK, p38 MAPK, and JNK. Treatment with a PKC inhibitor showed that phosphory...

journal_title：Biochemical and biophysical research communications

authors： Imura T,Shimohama S,Kageyama T,Kimura J

更新日期：1999-11-01 00:00:00

abstract：:We characterized senile plaques (SPs) immunohistochemically in cynomolgus monkey brains and also examined age-related biochemical changes of Alzheimer's disease (AD)-associated proteins in these brains from monkeys of various ages. In the neocortex of aged monkeys (>20 years old), we found SPs but no neurofibrillary t...

journal_title：Biochemical and biophysical research communications

authors： Kimura N,Tanemura K,Nakamura S,Takashima A,Ono F,Sakakibara I,Ishii Y,Kyuwa S,Yoshikawa Y

更新日期：2003-10-17 00:00:00

abstract：:Members of the heparan sulfate proteoglycan family, the syndecans have emerged as integrators of extracellular signals, such as ECM components or growth factors, that activate cytoplasmic signaling cascades and regulate cytoskeletal functions. Specifically, syndecan-2 has been implicated in various cellular processes,...

journal_title：Biochemical and biophysical research communications

authors： Contreras HR,Fabre M,Granés F,Casaroli-Marano R,Rocamora N,Herreros AG,Reina M,Vilaró S

更新日期：2001-08-31 00:00:00

abstract：:Tetrahydrobiopterin (BH(4)) synthesis is reported to be stimulated by nerve growth factor (NGF) in PC12 cells, suggesting involvement of BH(4) in the trophic effect of NGF. We have recently reported that erythropoietin (EPO) and BH(4) enhance survival of PC12 cells. In the present study, we investigated involvement of...

journal_title：Biochemical and biophysical research communications

authors： Tanaka J,Koshimura K,Sohmiya M,Murakami Y,Kato Y

更新日期：2001-11-30 00:00:00

abstract：:Colorectal cancer is one of the most common malignant tumors worldwide with rising incidence. MicroRNAs are small non-coding RNAs that implicate in multiple physiological or pathological processes. The aberrant expression of miRNA-215 (miR-215) has been illustrated in various types of cancers. However, the expression ...

journal_title：Biochemical and biophysical research communications

authors： Chen Z,Han S,Huang W,Wu J,Liu Y,Cai S,He Y,Wu S,Song W

更新日期：2016-10-21 00:00:00

abstract：:In the rat, pancreatic HCO(-)(3) secretion is believed to be mediated by duct cells with an apical Cl(-)/HCO(-)(3) exchanger acting in parallel with a cAMP-activated Cl(-) channel and protons being extruded through a basolateral Na(+)/H(+) exchanger. However, this may not be the only mechanism for HCO(-)(3) secretion ...

journal_title：Biochemical and biophysical research communications

authors： Thévenod F,Roussa E,Schmitt BM,Romero MF

更新日期：1999-10-14 00:00:00

abstract：:In the clinical field, cell-based therapies are used to treat bone defects. Adipose tissues contain many osteoblast progenitors, among other cell types. We separated mouse adipose tissue-derived stromal cells (ATSCs) according to their cell adhesive properties. Cells in a fraction adherent to the culture dishes 0.5h a...

journal_title：Biochemical and biophysical research communications

authors： Hattori H,Ishihara M,Fukuda T,Suda T,Katagiri T

更新日期：2006-05-19 00:00:00

abstract：:A novel protein methyltransferase has been recently described that catalyzes the esterification of the C-terminal leucine residue of the catalytic subunit of protein phosphatase 2A in a variety of eucaryotic cells. This reaction can potentially modulate the phosphatase's activity, subunit interactions, or interactions...

journal_title：Biochemical and biophysical research communications

authors： Xie H,Clarke S

更新日期：1994-09-30 00:00:00

abstract：:The addition of low concentrations of the chemotactic factor fMet-Leu-Phe to rabbit neutrophils in the absence of cytochalasin B produces very little superoxide. This level of superoxide can be greatly increased in neutrophils pretreated for 30 min with 10 microM of the diacyl-glycerol kinase inhibitor R59022. This po...

journal_title：Biochemical and biophysical research communications

authors： Gomez-Cambronero J,Molski TF,Becker EL,Sha'afi RI

更新日期：1987-10-14 00:00:00

abstract：:Glucose-dependent insulinotropic polypeptide is an incretin hormone that stimulates insulin secretion and reduces postprandial glycaemic excursions. The glucose-dependent action of GIP on pancreatic beta-cells has attracted attention towards its exploitation as a potential drug for type 2 diabetes. Use of NMR or X-ray...

journal_title：Biochemical and biophysical research communications

authors： Alaña I,Hewage CM,Malthouse JP,Parker JC,Gault VA,O'Harte FP

更新日期：2004-12-03 00:00:00

abstract：:Coenzyme Q10 (CoQ10) protects retinal ganglion cells (RGCs) in experimental retinal ischemia and glaucoma by scavenging reactive oxygen species. We tested whether a diet supplemented with ubiquinol, the reduced form of CoQ10, promotes RGC survival and blocks the apoptotic pathway in ischemic mouse retina induced by ac...

journal_title：Biochemical and biophysical research communications

authors： Ju WK,Shim MS,Kim KY,Bu JH,Park TL,Ahn S,Weinreb RN

更新日期：2018-09-18 00:00:00

abstract：:Using genomic restriction analysis of 14 unrelated patients with salt-losing congenital adrenal hyperplasia, we identified three different CA21HB mutation patterns: no detectable restriction fragment abnormalities (16/28 haplotypes), deletion of the active CA21HB gene (9/28), and apparent conversion of the active CA21...

journal_title：Biochemical and biophysical research communications

authors： Jospe N,Donohoue PA,Van Dop C,McLean RH,Bias WB,Migeon CJ

更新日期：1987-02-13 00:00:00

abstract：:Different groups including ours have shown that curcumin induces melanoma cell apoptosis, here we focused the role of mammalian Sterile 20-like kinase 1 (MST1) in it. We observed that curcumin activated MST1-dependent apoptosis in cultured melanoma cells. MST1 silencing by RNA interference (RNAi) suppressed curcumin-i...

journal_title：Biochemical and biophysical research communications

authors： Yu T,Ji J,Guo YL

更新日期：2013-11-08 00:00:00

abstract：:Heme oxygenase-1 (HO-1) is an inducible form of heme oxygenase that catabolizes heme to carbon monoxide, biliverdin, and ferrous iron. We have investigated whether HO-1 can induce angiogenic effects in vivo. Rats were subjected to a bolus injection of either wild type adenovirus (ad-wt) or adenovirus encoding HO-1 (ad...

journal_title：Biochemical and biophysical research communications

authors： Suzuki M,Iso-o N,Takeshita S,Tsukamoto K,Mori I,Sato T,Ohno M,Nagai R,Ishizaka N

更新日期：2003-02-28 00:00:00

abstract：:To study the role of Rab3A in regulated secretion, recombinant Rab3A protein plus various guanine nucleotides were perfused into bovine adrenal chromaffin cells via a patch pipette, and depolarization-evoked catecholamine secretion from individual cells was measured by amperometry. Rab3A plus GTP, GDP, and GTP gamma S...

journal_title：Biochemical and biophysical research communications

authors： Lin CG,Pan CY,Kao LS

更新日期：1996-04-25 00:00:00

abstract：:Semicarbazide-sensitive amine oxidase (SSAO) activity in plasma is increased in diabetes, and in particular, in diabetic patients with vascular complications. It has been speculated that SSAO is involved in the development of such complications due to the production of cytotoxic compounds. In this work, we have induce...

journal_title：Biochemical and biophysical research communications

authors： Gokturk C,Nordquist J,Sugimoto H,Forsberg-Nilsson K,Nilsson J,Oreland L

更新日期：2004-12-17 00:00:00

abstract：:We proposed to use a novel stepwise sequence-constructive SELEX method to develop DNA aptamers that can recognize Globo H which is a tumor-associated carbohydrate antigen. A combinatorial synthetic library that consisted of DNA molecules with randomized regions of 15-bases was used as the starting library for the firs...

journal_title：Biochemical and biophysical research communications

authors： Wang CY,Wu CY,Hung TC,Wong CH,Chen CH

更新日期：2014-09-26 00:00:00

abstract：:Human Molt3 cDNA library was constructed using pcD vector system which permits the expression of cDNA inserts in mammalian cells. Nearly full-length human terminal deoxynucleotidyltransferase (TdT) cDNA was cloned using a fragment of bovine TdT cDNA as a probe. The human TdT cDNA contains an open reading frame of 1,55...

journal_title：Biochemical and biophysical research communications

authors： Koiwai O,Kaneda T,Morishita R

更新日期：1987-04-14 00:00:00

abstract：:Contact inhibition is a crucial mechanism regulating proliferation in vitro and in vivo. Despite its generally accepted importance for maintaining tissue homeostasis knowledge about the underlying molecular mechanisms of contact inhibition is still scarce. Since the MAPK ERK1/2 plays a pivotal role in the control of p...

journal_title：Biochemical and biophysical research communications

authors： Küppers M,Faust D,Linz B,Dietrich C

更新日期：2011-03-18 00:00:00

abstract：UNLABELLED:The L-arginine-nitric oxide (NO) pathway was investigated in human internal mammary artery (HIMA) in vitro. HIMA rings were mounted in organ bath, and then incubated in Krebs buffer for 1 to 8 hrs, relaxing agents were tested. Under these conditions, L-arginine (0.1 microM - 1 mM) elicited only minor relaxat...

journal_title：Biochemical and biophysical research communications

authors： Qi X,Chen D,Nottin R,Mace L,Herve P,Weiss M

更新日期：1993-08-31 00:00:00

abstract：:Although a large collection of cancer cell lines are useful surrogates for patient samples, the physiological relevance of observed molecular phenotypes in cell lines remains controversial. Because transcriptome data are a representative set of molecular phenotypes in cancers, we systematically analyzed the discrepanc...

journal_title：Biochemical and biophysical research communications

authors： Hong Y,Kim N,Li C,Jeong E,Yoon S

更新日期：2017-05-27 00:00:00

abstract：:Phosphatases play an important role in cellular signaling and are often found dysregulated in cancers including glioblastoma (GBM). A comprehensive bioinformatics analysis of phosphatases (n = 403) in multiple datasets revealed their deregulation in GBM. Among the differentially regulated phosphatases (n = 186; 46.1%)...

journal_title：Biochemical and biophysical research communications

authors： Tomar VS,Baral TK,Nagavelu K,Somasundaram K

更新日期：2019-07-12 00:00:00

abstract：:A two fold stimulation in the incorporation of [3H-methyl] groups from [3H-methyl] methionine into phospholipids was seen in intact pancreatic islets within six minutes of exposure to a glucose concentration that stimulates insulin release. Nonstimulatory sugars, L-glucose and D-galactose, as well as dibutyryl cAMP, d...

journal_title：Biochemical and biophysical research communications

authors： Kowluru A,Rana RS,MacDonald MJ

更新日期：1984-07-31 00:00:00

abstract：:Mycobacterium tuberculosis, the causative agent of tuberculosis disease, is one among the deadliest pathogens in the world. Due to long treatment regimen, HIV co-infection, persistence of bacilli in latent form and development of XDR and TDR strains of Mtb, tuberculosis has posed serious concerns for managing the dise...

journal_title：Biochemical and biophysical research communications

authors： Gopalan A,Bhagavat R,Chandra N,Subbarao SH,Raja A,Bethunaickan R

更新日期：2018-02-12 00:00:00

abstract：:Using a culture system that facilitates osteogenic differentiation of bone marrow-derived human mesenchymal stem cells, we analyzed gene-expression profiles during the mineralization process by means of a cDNA microarray system consisting of 23,040 genes. We compared expression profiles of the cells at days 3, 15, and...

journal_title：Biochemical and biophysical research communications

authors： Doi M,Nagano A,Nakamura Y

更新日期：2002-01-11 00:00:00

abstract：:Aggregation of amyloid beta-peptide (Abeta), a key pathological event in Alzheimer's disease, has been shown in vitro to be profoundly promoted by Zn(II). This fact suggests that some factors in the normal brain protect Abeta from the Zn(II)-induced aggregation. We demonstrate for the first time that Cu(II) effectivel...

journal_title：Biochemical and biophysical research communications

authors： Suzuki K,Miura T,Takeuchi H

更新日期：2001-07-27 00:00:00