当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > NMR structure of the glucose-dependent insulinotropic polypeptide fragment, GIP(1-30)amide.

NMR structure of the glucose-dependent insulinotropic polypeptide fragment, GIP(1-30)amide.

Abstract：

:Glucose-dependent insulinotropic polypeptide is an incretin hormone that stimulates insulin secretion and reduces postprandial glycaemic excursions. The glucose-dependent action of GIP on pancreatic beta-cells has attracted attention towards its exploitation as a potential drug for type 2 diabetes. Use of NMR or X-ray crystallography is vital to determine the three-dimensional structure of the peptide. Therefore, to understand the basic structural requirements for the biological activity of GIP, the solution structure of the major biologically active fragment, GIP(1-30)amide, was investigated by proton NMR spectroscopy and molecular modelling. The structure is characterised by a full length alpha-helical conformation between residues F(6) and A(28). This structural information could play an important role in the design of therapeutic agents based upon GIP receptor agonists.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Alaña I,Hewage CM,Malthouse JP,Parker JC,Gault VA,O'Harte FP

doi

10.1016/j.bbrc.2004.10.033

subject

Has Abstract

pub_date

2004-12-03 00:00:00

pages

281-6

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(04)02341-1

journal_volume

325

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Modulation of adenine nucleoside excretion and incorporation in adenosine deaminase deficient human lymphoma cells.

    abstract：:The availability of a human lymphoma cell line deficient in adenosine deaminase, adenosine kinase and methylthioadenosine phosphorylase enabled us to compare the effects of nucleoside transport inhibitors on the excretion of endogenously generated adenosine, deoxyadenosine and 5'-methylthioadenosine. The nucleoside tr...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(84)90212-2

    authors： Iizasa T,Kubota M,Carson DA

    更新日期：1984-06-15 00:00:00

  • Hepatitis C virus NS3 RNA helicase activity is modulated by the two domains of NS3 and NS4A.

    abstract：:To determine whether the two domains of hepatitis C virus (HCV) NS3 and the NS4A interact with each other to regulate the RNA unwinding activity, this study compares the RNA unwinding, ATPase and RNA binding activities of three forms of NS3 proteins--the NS3H protein, containing only the helicase domain, the full-leng...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.03.032

    authors： Kuang WF,Lin YC,Jean F,Huang YW,Tai CL,Chen DS,Chen PJ,Hwang LH

    更新日期：2004-04-23 00:00:00

  • Endogenous production of nitric oxide by vascular endothelial growth factor down-regulates proliferation of choriocarcinoma cells.

    abstract：:The trophoblast-like choriocarcinoma cell line BeWo expresses a receptor for vascular endothelial growth factor (VEGF) and proliferates in response to VEGF. Nitric oxide (NO) seems to play a key role in the VEGF-induced proliferation of endothelial cells but the NO mechanistic regulation of VEGF-stimulated trophoblast...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.4682

    authors： Cha MS,Lee MJ,Je GH,Kwak JY

    更新日期：2001-04-13 00:00:00

  • Isolation of a human liver ligandin cDNA clone and demonstration of sequence homology at ligandin loci in rats and humans.

    abstract：:Using a monospecific antibody to the major cytosolic glutathione-S-transferase of human liver, we have isolated a cDNA clone from a human liver cDNA expression vector library in lambda gt11. The clone cross-hybridizes with a rat liver ligandin (glutathione-S-transferase 1-2) cDNA probe. The clone has an insert of 1.25...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(87)91511-7

    authors： Butera L,Monnier JR,Campbell E,Bhargava MM

    更新日期：1987-02-13 00:00:00

  • The specific bisindolylmaleimide PKC-inhibitor GF 109203X efficiently modulates MRP-associated multiple drug resistance.

    abstract：:The newly identified drug transporter MRP is functionally linked to a multiple drug resistance independent from P-glycoprotein. Resistance modifiers for this type of MDR are rare at present. We analyzed the modulating effect of the highly selective bisindolylmaleimide PKC inhibitor GF 109203X on the MRP overexpressing...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.1017

    authors： Gekeler V,Boer R,Ise W,Sanders KH,Schächtele C,Beck J

    更新日期：1995-01-05 00:00:00

  • HSP27 phosphorylation protects against endothelial barrier dysfunction under burn serum challenge.

    abstract：:F-actin rearrangement is an early event in burn-induced endothelial barrier dysfunction. HSP27, a target of p38 MAPK/MK2 pathway, plays an important role in actin dynamics through phosphorylation. The question of whether HSP27 participates in burn-related endothelial barrier dysfunction has not been identified yet. He...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.04.152

    authors： Sun HB,Ren X,Liu J,Guo XW,Jiang XP,Zhang DX,Huang YS,Zhang JP

    更新日期：2015-07-31 00:00:00

  • Involvement of endogenous neuromedin U and neuromedin S in thermoregulation.

    abstract：:We investigated the possible involvement of neuromedin U (NMU) and neuromedin S (NMS) in thermoregulation in rats. Intracerebroventricular (icv) injection of NMU or NMS increased the back surface temperature (BS-T) in a dose-dependent manner during both the light and dark periods. Pre-treatment with the β3 blocker SR5...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.01.155

    authors： Nakahara K,Akagi A,Shimizu S,Tateno S,Qattali AW,Mori K,Miyazato M,Kangawa K,Murakami N

    更新日期：2016-02-19 00:00:00

  • Nucleophosmin/B23 regulates PCNA promoter through YY1.

    abstract：:Ectopic over-expression of nucleophosmin/B23 caused a marked up-regulation in the amounts of Yin Yang 1 (YY1) and proliferating cellular nuclear antigen (PCNA) proteins. Transfection with nucleophosmin/B23-targeting siRNA induced a decrease in the intracellular amounts of nucleophosmin/B23, YY1, and PCNA. PCNA express...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.07.150

    authors： Weng JJ,Yung BY

    更新日期：2005-09-30 00:00:00

  • Proprotein convertases regulate insulin-like growth factor 1-induced membrane-type 1 matrix metalloproteinase in VSMCs via endoproteolytic activation of the insulin-like growth factor-1 receptor.

    abstract：:The IGF-1 receptor (IGF-1R) and MT1-MMP are synthesized as larger precursor proproteins, which require endoproteolytic activation by the proprotein convertases (PCs) furin/PC5 to gain full biological activity. The aim of this study was to investigate the contribution of PCs to IGF-1R and/or MT1-MMP activation in vascu...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.07.001

    authors： Stawowy P,Kallisch H,Kilimnik A,Margeta C,Seidah NG,Chrétien M,Fleck E,Graf K

    更新日期：2004-08-27 00:00:00

  • Butyrate suppresses Cox-2 activation in colon cancer cells through HDAC inhibition.

    abstract：:Cox-2 plays an important role in colon carcinogenesis and inflammation. Studying the HT-29 colon cancer cell line as a model, we found that Cox-2 expression and activity is increased approximately 25-fold by TNF-alpha. As previously reported for other Cox-2 inducers, this activation appears to result from a p38-mediat...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.03.066

    authors： Tong X,Yin L,Giardina C

    更新日期：2004-04-30 00:00:00

  • Synthesis and in vitro activity of a hormone-diphtheria toxin fragment A hybrid.

    abstract：:The synthesis and in vitro biological activity of a hybrid protein composed of intact human chorionic gonadotropin and fragment A of diphtheria toxin in a disulfide conjugate is reported. This hybrid retained greater than 90% of the binding ability of uncoupled hCG and was shown to be specifically toxic to a mouse Ley...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(85)90924-6

    authors： Oeltmann TN

    更新日期：1985-12-17 00:00:00

  • Two forms of AMP deaminase from chicken liver.

    abstract：:Chromatography of chicken liver AMP deaminase on phosphocellulose and DEAE-Sephacel revealed the existence of two separate peaks of enzyme activity. Significant differences have been observed between form I and II of the enzyme in respect to substrate specificity and their kinetic and regulatory properties. ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(83)90662-9

    authors： Spychała J,Makarewicz W

    更新日期：1983-08-12 00:00:00

  • Metabolomic analysis revealed mitochondrial dysfunction and aberrant choline metabolism in MPP+-exposed SH-SY5Y cells.

    abstract：:1-Methyl-4-phenylpyridinium (MPP+)-treated human neuroblastoma SH-SY5Y cells have been generally accepted as a cellular model for Parkinson's disease. To understand comprehensive metabolic disturbances in this model, both cell lysates and culture supernatants were subjected to metabolomic analysis. As expected from th...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.09.031

    authors： Amo T,Oji Y,Saiki S,Hattori N

    更新日期：2019-11-12 00:00:00

  • Measurement of intracellular IP3 during Ca2+ oscillations in mouse eggs with GFP-based FRET probe.

    abstract：:Intracellular Ca2+ oscillations in fertilized mammalian eggs, the key signal that stimulates egg activation and early embryonic development, are regulated by inositol 1,4,5-trisphosphate (IP3) signaling pathway. We investigated temporal changes in intracellular IP3 concentration ([IP3]i) in mouse eggs, using a fluores...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.04.133

    authors： Shirakawa H,Ito M,Sato M,Umezawa Y,Miyazaki S

    更新日期：2006-06-30 00:00:00

  • Classical NF-κB pathway is responsible for APOBEC3B expression in cancer cells.

    abstract：:APOBEC3B (A3B) is a DNA cytosine deaminase and catalyzes cytosine deamination, resulting in mutations in genomic DNA. A3B is aberrantly expressed in a variety of cancers and considered to be a source of genomic mutations that contribute to cancer progression and metastasis. However, the mechanisms through which A3B ex...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.08.148

    authors： Maruyama W,Shirakawa K,Matsui H,Matsumoto T,Yamazaki H,Sarca AD,Kazuma Y,Kobayashi M,Shindo K,Takaori-Kondo A

    更新日期：2016-09-23 00:00:00

  • Induction of the ethanol-inducible form of rabbit liver microsomal cytochrome P-450 by inhibitors of alcohol dehydrogenase.

    abstract：:Cytochrome P-450 LMeb was purified from liver microsomes obtained from rabbits treated with either benzene or imidazole and was shown to have identical N-terminal amino acid sequence as that of cytochrome P-450 LM3a. The amino acid compositions of the proteins were indistinguishable. Quantitation of P-450 LMeb in vari...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(84)91563-8

    authors： Ingelman-Sundberg M,Jörnvall H

    更新日期：1984-10-30 00:00:00

  • 6-sulfooxymethylbenzo[a]pyrene is an ultimate electrophilic and carcinogenic form of the intermediary metabolite 6-hydroxymethylbenzo[a]pyrene.

    abstract：:Previous experiments have demonstrated that the intermediary metabolite 6-hydroxymethylbenzo[a] pyrene (HMBP) can be activated to the electrophilic mutagen, 6-sulfooxymethylbenzo[a]pyrene (SMBP), by rat and mouse liver PAPS-dependent sulfotransferase activity or by chemical synthesis. This aralkylating metabolite and ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1997.6679

    authors： Flesher JW,Horn J,Lehner AF

    更新日期：1997-05-29 00:00:00

  • IL-2-mediated upregulation of uPA and uPAR in natural killer cells.

    abstract：:Urokinase plasminogen activator (uPA) and its receptor uPAR play a major role in immune cell-mediated, including natural killer (NK) cell-mediated, degradation of extracellular matrices. Herein, we investigate the effects of IL-2 on NK cell uPA and uPAR. RNA and protein analyses showed upregulation of uPA and uPAR fol...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2002.6627

    authors： Al-Atrash G,Shetty S,Idell S,Xue Y,Kitson RP,Halady PK,Goldfarb RH

    更新日期：2002-03-22 00:00:00

  • Evaluation of viral and mammalian promoters for driving transgene expression in mouse liver.

    abstract：:Fifteen luciferase plasmid constructs driven by various promoters including cytomegalovirus (CMV), Rous sarcoma virus (RSV), human serum albumin (SA), alpha-1 antitrypsin (AAT), cytochrome P450 CYP1A2, CYP2C9, CYP2C18, CYP2D6, CYP3A4, mouse CYP2b10, human amyloid precursor protein (APP), chicken beta actin (ACT), nucl...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.11.063

    authors： Al-Dosari M,Zhang G,Knapp JE,Liu D

    更新日期：2006-01-13 00:00:00

  • Expression of c-myc oncogene during differentiation of human burst-forming unit, erythroid (BFU-E).

    abstract：:We investigated the serial expression of c-myc oncogene during differentiation of normal human burst-forming unit, erythroid (BFU-E), in vitro, together with the replating efficiency and the expression of transferrin receptors. We found that the c-myc oncogene was expressed in the early progeny of BFU-E and that this ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(86)90025-2

    authors： Umemura T,Umene K,Nishimura J,Fukumaki Y,Sakaki Y,Ibayashi H

    更新日期：1986-03-13 00:00:00

  • Effective treatment of glioblastoma requires crossing the blood-brain barrier and targeting tumors including cancer stem cells: The promise of nanomedicine.

    abstract：:Glioblastoma multiforme (GBM) is the most aggressive and lethal type of brain tumor. Both therapeutic resistance and restricted permeation of drugs across the blood-brain barrier (BBB) play a major role in the poor prognosis of GBM patients. Accumulated evidence suggests that in many human cancers, including GBM, ther...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章,评审

    doi：10.1016/j.bbrc.2015.06.137

    authors： Kim SS,Harford JB,Pirollo KF,Chang EH

    更新日期：2015-12-18 00:00:00

  • Respiratory syncytial virus infection activates STAT signaling in human epithelial cells.

    abstract：:Acute respiratory syncytial virus (RSV) infection causes airway inflammation and exacerbates asthma, but the mechanism of inflammation is poorly understood. The role of the STAT-signaling pathway in RSV infection in epithelial cells was examined in this study. DNA microarray analyses of RSV-infected human alveolar typ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(03)01008-8

    authors： Kong X,San Juan H,Kumar M,Behera AK,Mohapatra A,Hellermann GR,Mane S,Lockey RF,Mohapatra SS

    更新日期：2003-06-27 00:00:00

  • Differential expression of wild-type and variant ER mRNAs by stocks of MCF-7 breast cancer cells may account for differences in estrogen responsiveness.

    abstract：:The MCF-7 human breast cancer cell line is routinely used as a model system for the study of ER+, estrogen-responsive human breast cancer. Although most investigators have found these cells to be estrogen-responsive, there are reports that some stocks of MCF-7 cells may be either insensitive or may display decreased s...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.1702

    authors： Klotz DM,Castles CG,Fuqua SA,Spriggs LL,Hill SM

    更新日期：1995-05-16 00:00:00

  • Rosiglitazone enhances the radiosensitivity of p53-mutant HT-29 human colorectal cancer cells.

    abstract：:Combined-modality treatment has improved the outcome in cases of various solid tumors, and radiosensitizers are used to enhance the radiotherapeutic efficiency. Rosiglitazone, a synthetic ligand of peroxisome proliferator-activated receptors gamma used in the treatment of type-2 diabetes, has been shown to reduce tumo...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.03.068

    authors： Chiu SJ,Hsaio CH,Tseng HH,Su YH,Shih WL,Lee JW,Chuah JQ

    更新日期：2010-04-09 00:00:00

  • The adult polyglucosan body disease mutation GBE1 c.1076A>C occurs at high frequency in persons of Ashkenazi Jewish background.

    abstract：:Mutations of the glycogen branching enzyme gene, GBE1, result in glycogen storage disease (GSD) type IV, an autosomal recessive disorder having multiple clinical forms. One mutant allele of this gene, GBE1 c.1076A>C, has been reported in Ashkenazi Jewish cases of an adult-onset form of GSD type IV, adult polyglucosan ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.08.089

    authors： Hussain A,Armistead J,Gushulak L,Kruck C,Pind S,Triggs-Raine B,Natowicz MR

    更新日期：2012-09-21 00:00:00

  • MicroRNA-29a mitigation of toll-like receptor 2 and 4 signaling and alleviation of obstructive jaundice-induced fibrosis in mice.

    abstract：:Cholestasis and hepatitis can cause continuous liver damage that may ultimately result in liver fibrosis. In a previous study, we demonstrated that microRNA-29a (miR-29a) protects against liver fibrosis. Toll-like receptor 2 (TLR2) and TLR4 are pattern recognition receptors of bacterial lipoprotein and lipopolysacchar...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.01.132

    authors： Lin YC,Wang FS,Yang YL,Chuang YT,Huang YH

    更新日期：2018-02-12 00:00:00

  • Establishment of a novel method for the identification of fertilization defective mutants in Arabidopsis thaliana.

    abstract：:Plant reproduction is an extremely important phenomenon, as it is strongly associated with plant genetics and early development. Additionally, foundations of the reproductive system have direct implications on plant breeding and agriculture. Investigation of the functions of male and female gametophytes is critical si...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.11.028

    authors： Liu X,Wu X,Adhikari PB,Zhu S,Kinoshita Y,Berger F,Higashiyama T,Kasahara RD

    更新日期：2020-01-22 00:00:00

  • Wnt-16a, a novel Wnt-16 isoform, which shows differential expression in adult human tissues.

    abstract：:The WNT genes encode a large family of secreted glycoprotein signalling molecules important from the earliest stages of development through to the adult. We have identified a novel isoform of the recently described WNT family member, Wnt16, following analysis of chromosome 7q31 genomic sequence. We find differential o...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2000.3852

    authors： Fear MW,Kelsell DP,Spurr NK,Barnes MR

    更新日期：2000-11-30 00:00:00

  • Platelet activation during tumor development, the potential role of BDNF-TrkB autocrine loop.

    abstract：:Platelets are an important place for the storage of angiogenic factors, such as vascular endothelial growth factor (VEGF) and brain-derived neurotrophic factor (BDNF). The present study aims to investigate the interaction between BDNF-TrkB pathway and platelet activation during tumor development. In an orthotopic hepa...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.06.007

    authors： Yang ZF,Ho DW,Lau CK,Tam KH,Lam CT,Poon RT,Fan ST

    更新日期：2006-08-04 00:00:00

  • Impaired growth of pancreatic exocrine cells in transgenic mice expressing human activin betaE subunit.

    abstract：:Activins, TGF-beta superfamily members, have multiple functions in a variety of cells and tissues. Recently, additional activin beta subunit genes, betaC and betaE, have been identified. To explore the role of activin E, we created transgenic mice overexpressing human activin betaE subunit. There were pronounced diffe...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.12.205

    authors： Hashimoto O,Ushiro Y,Sekiyama K,Yamaguchi O,Yoshioka K,Mutoh K,Hasegawa Y

    更新日期：2006-03-10 00:00:00