Respiratory syncytial virus infection activates STAT signaling in human epithelial cells.

abstract：:Infections with Pseudomonas aeruginosa (P. aeruginosa) are critical in ventilated and poly-traumatized patients. Most important, these bacteria cause frequent and chronic pulmonary infections in patients with cystic fibrosis. Therefore, identification of molecular mechanisms that mediate the infection of mammalian cel...

journal_title：Biochemical and biophysical research communications

authors： Kirschnek S,Adams C,Gulbins E

更新日期：2005-02-18 00:00:00

abstract：:GTP cyclohydrolase I is the rate-limiting enzyme in the de novo synthesis pathway of tetrahydrobiopterin which is an essential cofactor for all NO synthase isoforms. The expression of GTP cyclohydrolase I is regulated on a transcriptional level by a variety of cytokines like interleukin 1beta or tumor necrosis factor ...

journal_title：Biochemical and biophysical research communications

authors： Lapize C,Plüss C,Werner ER,Huwiler A,Pfeilschifter J

更新日期：1998-10-29 00:00:00

abstract：:The suppressor of cytokine signalling 1 protein (SOCS-1) belongs to a novel family of cytokine inducible factors which function as inhibitors of the JAK/STAT pathway. While SOCS-1 previously has been described as a single-exon gene, here we present evidence for an additional 5' exon, separated by a 509 bp intron from ...

journal_title：Biochemical and biophysical research communications

authors： Schlüter G,Boinska D,Nieman-Seyde SC

更新日期：2000-02-16 00:00:00

abstract：:p38 MAPK and nuclear factor-B (NF-B) signaling pathways play an indispensable role in the control of skeletal myogenesis. The specific contribution of these signaling pathways to the response of myoblast to the mechanical stimulation and the molecular mechanisms underlying this response remain unresolved. Using an est...

journal_title：Biochemical and biophysical research communications

authors： Ji G,Liu D,Liu J,Gao H,Yuan X,Shen G

更新日期：2010-01-01 00:00:00

abstract：:Surgery and chemotherapy are the gold-standard treatments for ovarian cancer. The major cause of treatment failure in patients with ovarian cancer is tumoral heterogeneity and drug resistance. Paclitaxel (PTX) is one of the most commonly used first-line drugs for ovarian cancer chemotherapy. Unfortunately, the mechani...

journal_title：Biochemical and biophysical research communications

authors： Hong X,Li S,Li W,Xie M,Wei Z,Guo H,Wei W,Zhang S

更新日期：2019-01-15 00:00:00

abstract：:HNK-1 antibody reactive carbohydrate epitope carried by glycolipids and glycoproteins has been shown to be involved in cell to cell interactions. It has been proposed that the HNK-1 reactive 3-sulfoglucuronyl carbohydrate epitope in glycolipids may interact with a cell surface receptor to promote the biological respon...

journal_title：Biochemical and biophysical research communications

authors： Mohan PS,Laitinen J,Merenmies J,Rauvala H,Jungalwala FB

更新日期：1992-01-31 00:00:00

abstract：:Two neuropeptides (DCCI and DCCII) in the adipokinetic/red pigment concentrating hormone-family have been isolated and purified from the corpora cardiaca of horseflies (Diptera : Tabanidae). Both peptides were purified by a sequence of three reversed phase-high performance liquid chromatographic steps. Amino acid anal...

journal_title：Biochemical and biophysical research communications

authors： Jaffe H,Raina AK,Fraser BA,Keim P,Rao KR,Zhang YS,Lancaster JL,Hayes DK

更新日期：1988-03-15 00:00:00

abstract：:In the early postnatal period, cerebellar granule cells exhibit an activity-dependent downregulation of a set of immaturation genes involved in cell growth and migration and are shifted to establishment of a mature network formation. Through the use of a granule cell culture and both pharmacological and RNA interferen...

journal_title：Biochemical and biophysical research communications

authors： Okazawa M,Abe H,Nakanishi S

更新日期：2016-05-13 00:00:00

abstract：:Small-angle X-ray scattering of one high molecular weight (HMW) subunit of wheat glutenin was measured at protein concentration ranges from 1.0 to 10.0 mg/ml. The radius of gyration of whole particles, RO, in aq. 50% (v/v) 1-propanol and 0.1M acetic acid was 16.6 +/- 0.1nm and 22.8nm, respectively, and the correspondi...

journal_title：Biochemical and biophysical research communications

authors： Matsushima N,Danno G,Sasaki N,Izumi Y

更新日期：1992-07-31 00:00:00

abstract：:Leukocyte recruitment to lymph nodes or inflammatory sites is regulated by adhesion and activation. L-selectin (CD62L) is expressed on leukocytes and mediates tethering and rolling of leukocytes on endothelial cells. Upon stimulation L-selectin is down-regulated by proteolytic cleavage but the molecular mechanisms reg...

journal_title：Biochemical and biophysical research communications

authors： Phong MC,Gutwein P,Kadel S,Hexel K,Altevogt P,Linderkamp O,Brenner B

更新日期：2003-01-10 00:00:00

abstract：:Trigonelline (N-methylnicotinate), a member of the pyridine alkaloids, accumulates in coffee beans along with caffeine. The biosynthetic pathway of trigonelline is not fully elucidated. While it is quite likely that the production of trigonelline from nicotinate is catalyzed by N-methyltransferase, as is caffeine synt...

journal_title：Biochemical and biophysical research communications

authors： Mizuno K,Matsuzaki M,Kanazawa S,Tokiwano T,Yoshizawa Y,Kato M

更新日期：2014-10-03 00:00:00

abstract：:HSV-2 induces the transcription of c-fos gene in both human (diploid) cell strains and mouse (heteroploid) cell lines. HSV-1 is incapable of such induction. The induction of transcription is rapid and transient in both cell types. The product of transcriptional induction of c-fos in mouse cells is mainly a 4.5 kb fos ...

journal_title：Biochemical and biophysical research communications

authors： Goswami BB

更新日期：1987-03-30 00:00:00

abstract：:The proton-translocating pyridine nucleotide transhydrogenase of Escherichia coli is composed of two types of subunits, alpha and beta, organized as an alpha(2)beta(2) tetramer. The protein contains three recognizable domains, of which domain II is the transmembrane region of the molecule containing the pathway for pr...

journal_title：Biochemical and biophysical research communications

authors： Hou C,Bragg PD

更新日期：2001-01-19 00:00:00

abstract：:The optimized geometry of the conformation of atoms constituting the 6-pyruvoyl tetrahydropterin molecule, the labile key intermediate of tetrahydrobiopterin biosynthesis, was obtained by molecular orbital calculations within the MINDO/3 framework. The stereostructure of the molecule showing the preferred mode for bin...

journal_title：Biochemical and biophysical research communications

authors： Katoh S,Sueoka T,Kurihara T

更新日期：1991-04-15 00:00:00

abstract：:Mutual interactions between adipocytes and immune cells in white adipose tissue (WAT) are involved in modulation of lipid metabolism in the tissue and also in response to omega-3 polyunsaturated fatty acids (PUFA), which counteract adverse effects of obesity. This complex interplay depends in part on in situ formed an...

journal_title：Biochemical and biophysical research communications

authors： Kuda O,Rombaldova M,Janovska P,Flachs P,Kopecky J

更新日期：2016-01-15 00:00:00

abstract：:SK24 and PT54 mutant cells, which are peroxisome-deficient Chinese hamster ovary (CHO) cells isolated using peroxisomal forms of green fluorescent protein (GFP), were found to be defective in the PEX2 gene. The nucleotide sequences of PEX2 cDNA from the mutant cells were determined to identify mutation sites in the mu...

journal_title：Biochemical and biophysical research communications

authors： Huang Y,Ito R,Miura S,Hashimoto T,Ito M

更新日期：2000-04-21 00:00:00

abstract：:The Rex-family repressors sense redox levels by alternative binding to NADH or NAD(+). RSP is the homologue of Rex in Thermoanaerobacter ethanolicus JW200(T) and regulates ethanol fermentation in this obligate anaerobe. The dimeric repressor binds to DNA by an open conformation. The crystal structure of RSP/α-NAD(+) c...

journal_title：Biochemical and biophysical research communications

authors： Zheng Y,Ko TP,Yang Y,Shao W,Guo RT

更新日期：2015-01-16 00:00:00

abstract：:Fragments of the human glutathione S-transferase pi gene and 15 kb of its 5' flanking region have been fused to the chloramphenicol acetyl transferase (CAT) reporter gene. Transfection into a number of human cell lines (Hela, HepG2, MCF7 and EJ) has demonstrated that the AP1 binding site, located between nucleotides -...

journal_title：Biochemical and biophysical research communications

authors： Xia CL,Cowell IG,Dixon KH,Pemble SE,Ketterer B,Taylor JB

更新日期：1991-04-15 00:00:00

abstract：:It is widely considered that it is not appropriate to treat beta-pairs in isolation, since other secondary structural models (such as helices, coils), protein topology and protein tertiary structures would limit beta-strand pairing. However, to understand the underlying mechanisms of beta-sheet formation, studies ough...

journal_title：Biochemical and biophysical research communications

authors： Zhang N,Ruan J,Duan G,Gao S,Zhang T

更新日期：2009-08-28 00:00:00

abstract：:Human Molt3 cDNA library was constructed using pcD vector system which permits the expression of cDNA inserts in mammalian cells. Nearly full-length human terminal deoxynucleotidyltransferase (TdT) cDNA was cloned using a fragment of bovine TdT cDNA as a probe. The human TdT cDNA contains an open reading frame of 1,55...

journal_title：Biochemical and biophysical research communications

authors： Koiwai O,Kaneda T,Morishita R

更新日期：1987-04-14 00:00:00

abstract：:Signalling through the chemokine stromal derived factor (SDF)-1alpha and its receptor CXCR4 has been recognized as a key event in the migratory response of hematopoietic stem and progenitor cells (HPC). Small GTPases of the Rho/Rac family might be involved in SDF-1alpha signalling at several different levels. In the p...

journal_title：Biochemical and biophysical research communications

authors： Henschler R,Piiper A,Bistrian R,Möbest D

更新日期：2003-11-28 00:00:00

abstract：:Imatinib mesylate, commercially known as Gleevec/Glivec, is the first targeted anticancer drug that inhibits activity of the tyrosine kinases, c-ABL, c-KIT, and PDGFR. A number of studies have shown that treatment with imatinib mesylate elicits extracellular signal-related kinase (ERK) activation, which, in turn, has ...

journal_title：Biochemical and biophysical research communications

authors： Lee J,Ko J,Kim HJ,Im H,Kim EJ,Yi JY

更新日期：2018-12-02 00:00:00

abstract：:During the late stage of homologous recombination in prokaryotes, RuvA binds to the Holliday junction intermediate and executes branch migration in association with RuvB. The RuvA subunits form two distinct complexes with the Holliday junction: complex I with the single RuvA tetramer on one side of the four way juncti...

journal_title：Biochemical and biophysical research communications

authors： Mayanagi K,Fujiwara Y,Miyata T,Morikawa K

更新日期：2008-01-11 00:00:00

abstract：:The human MEP1A gene encodes the meprin alpha subunit that consists of a protease domain conserved in the astacin family of metalloendopeptidases and several C-terminal interaction domains present in other proteins. Using the alpha subunit cDNA, we identified two clones from a human P1-derived artificial chromosome (P...

journal_title：Biochemical and biophysical research communications

authors： Jiang W,Beatty BG

更新日期：1999-07-22 00:00:00

abstract：:Lipoprotein lipase (LPL) catalyzes the hydrolysis of the triacylglycerol component of triacylglycerol-rich lipoproteins. There are 4 cysteine pairs that are completely conserved among LPLs of all species known. We examined the functional importance of each of the cysteine pairs in enzyme catalysis by examining LPLs pr...

journal_title：Biochemical and biophysical research communications

authors： Lo JY,Smith LC,Chan L

更新日期：1995-01-05 00:00:00

abstract：:Fructose is a key dietary factor in the development of nonalcoholic fatty liver disease (NAFLD). Here we investigated whether WAY-362450 (WAY), a potent synthetic and orally active FXR agonist, protects against fructose-induced steatosis and the underlying mechanisms. C57BL/6J mice, fed 30% fructose for 8 weeks, were ...

journal_title：Biochemical and biophysical research communications

authors： Liu X,Xue R,Ji L,Zhang X,Wu J,Gu J,Zhou M,Chen S

更新日期：2014-07-18 00:00:00

abstract：:Inhibition experiments with D-mannose oligosaccharides establish that conglutinin recognises terminal alpha 1----2 mannobiosyl units present in the glycopeptide of the alpha-chain of the complement component C3b. On the basis of its three domain structure and the homology of its N-terminal amino-acid sequence to that ...

journal_title：Biochemical and biophysical research communications

authors： Young NM,Leon MA

更新日期：1987-03-13 00:00:00

abstract：:A two-component regulatory system involving StyS and StyR is involved in the regulation of indigo synthesis in Pseudomonas sp. However, the function of the styR gene in indigo synthesis and the detailed mechanisms through which StyR enhances the expression of the styAB operon are unclear. Accordingly, in this study, w...

journal_title：Biochemical and biophysical research communications

authors： Cheng L,Yue J,Yin S,Ren M,Wang C

更新日期：2019-10-29 00:00:00

abstract：:The 5'-untranslated sequence of tobacco mosaic virus RNA--the so called omega leader--is a well-known translational enhancer. The structure of the omega RNA has unusual features. Despite the absence of extensive secondary structure of the Watson-Crick type, the omega RNA possesses a stable compact conformation. The ce...

journal_title：Biochemical and biophysical research communications

authors： Agalarov SC,Sogorin EA,Shirokikh NE,Spirin AS

更新日期：2011-01-07 00:00:00

abstract：:Bacillus thuringiensis (Bt), considered a safe insecticide, produces insecticidal proteins named Cry during sporulation, which possess exceptional immunological properties. In this work using an immunohistochemical test we demonstrated that Cry1Ac protoxin (pCry1Ac) binds to the mucosal surface of the mouse small inte...

journal_title：Biochemical and biophysical research communications

authors： Vázquez-Padrón RI,Gonzáles-Cabrera J,García-Tovar C,Neri-Bazan L,Lopéz-Revilla R,Hernández M,Moreno-Fierro L,de la Riva GA

更新日期：2000-04-29 00:00:00