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Respiratory syncytial virus infection activates STAT signaling in human epithelial cells.

Abstract：

:Acute respiratory syncytial virus (RSV) infection causes airway inflammation and exacerbates asthma, but the mechanism of inflammation is poorly understood. The role of the STAT-signaling pathway in RSV infection in epithelial cells was examined in this study. DNA microarray analyses of RSV-infected human alveolar type II (A549) epithelial cells identified several genes whose expression was altered from -5.5 to +56.4-fold. Four of the highly expressed genes contained STAT-binding elements. In A549 and normal human bronchial epithelial cells (NHBE), RSV induced phosphorylation and nuclear translocation of STAT-1alpha that was abrogated when RSV attachment was blocked. Treatment with a JAK-2 inhibitor or transfection with dominant-negative STAT-1alpha blocked STAT-1alpha activation and RSV infection. RSV also activated STAT-3 and IL-6 specific antibodies blocked this activation. Thus, activation of the STAT-1alpha and STAT-3 pathways play a role in RSV infection.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Kong X,San Juan H,Kumar M,Behera AK,Mohapatra A,Hellermann GR,Mane S,Lockey RF,Mohapatra SS

doi

10.1016/s0006-291x(03)01008-8

subject

Has Abstract

pub_date

2003-06-27 00:00:00

pages

616-22

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006291X03010088

journal_volume

306

pub_type

杂志文章

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