SDF-1alpha-induced intracellular calcium transient involves Rho GTPase signalling and is required for migration of hematopoietic progenitor cells.

abstract：:Epidemiological and experimental data suggest a role for polyunsaturated fatty acids in the etiology of breast cancer. In this report we have studied arachidonic acid and linoleic acid metabolism in the human breast carcinoma cell line BT-20 which overexpresses both EGF receptor and the homologous erbB-2 oncogene prod...

journal_title：Biochemical and biophysical research communications

authors： Reddy N,Everhart A,Eling T,Glasgow W

更新日期：1997-02-03 00:00:00

abstract：:Anchoring protein alphaKAP targets calmodulin kinase II (CaMKII) to the sarcoplasmic reticulum (SR), and in the rabbit is a substrate of CaMKII itself in fast-twitch, but not in slow-twitch muscle. This work was aimed at elucidating the molecular basis for differential phosphorylation of alphaKAP. Here we show that tw...

journal_title：Biochemical and biophysical research communications

authors： Damiani E,Sacchetto R,Salviati L,Margreth A

更新日期：2003-02-28 00:00:00

abstract：:Internal and environmental cues, including ambient temperature changes, regulate the timing of flowering in plants. Arabidopsis miR156 represses flowering and plays an important role in the regulation of temperature-responsive flowering. However, the molecular basis of miR156 processing at lower temperatures remains l...

journal_title：Biochemical and biophysical research communications

authors： Kim HE,Kim W,Lee AR,Jin S,Jun AR,Kim NK,Lee JH,Ahn JH

更新日期：2017-03-18 00:00:00

abstract：:The myelin basic proteins (MBPs) are a family of polypeptides that are predominantly expressed in the nervous system where they play a major role in myelination. We have generated four lines of transgenic mice carrying a transgene in which 1.34 kb of the 5'-flanking sequence of the mouse MBP gene was fused upstream of...

journal_title：Biochemical and biophysical research communications

authors： Asipu A,Mellor AL,Blair GE

更新日期：2001-11-09 00:00:00

abstract：:Progesterone (P4) and progesterone receptor (PR) have important functions in uterine environment. In previous studies, using high density DNA microarray analysis, we identified low density lipoprotein receptor-related protein 2 (Lrp2) is one of the genes upregulated by P4 and PR. In present studies, we examined the ex...

journal_title：Biochemical and biophysical research communications

authors： Oh SJ,Kim TH,Lim JM,Jeong JW

更新日期：2013-11-08 00:00:00

abstract：:Lysophosphatidylserine (LPS) was found to stimulate intracellular calcium increase in U87 human glioma cells. LPS also stimulated chemotactic migration of U87 human glioma cells, which was completely inhibited by pertussis toxin (PTX). Moreover, LPS was also found to stimulate ERK, p38 MAPK, JNK, and Akt activities in...

journal_title：Biochemical and biophysical research communications

authors： Lee SY,Lee HY,Kim SD,Jo SH,Shim JW,Lee HJ,Yun J,Bae YS

更新日期：2008-09-12 00:00:00

abstract：:Huntington's disease (HD) has been recently shown to have a horizontally transmitted, prion-like pathology. Thus, the migration of polyglutamine-containing aggregates to acceptor cells is important for the progression of HD. These aggregates contain glyceraldehyde-3-phosphate dehydrogenase (GAPDH), which increases the...

journal_title：Biochemical and biophysical research communications

authors： Lazarev VF,Mikhaylova ER,Dutysheva EA,Suezov RV,Guzhova IV,Margulis BA

更新日期：2017-06-03 00:00:00

abstract：:It has been generally viewed that salicylates ameliorate type 2 diabetes through interfering with the NF-kappaB signaling. Earlier studies indicated that IKKbeta was the key for the development of insulin resistance. However, it was unknown whether IKKbeta itself, or its downstream target, NF-kappaB, plays major roles...

journal_title：Biochemical and biophysical research communications

authors： Chen F

更新日期：2005-06-24 00:00:00

abstract：:In the present study, we characterized two new SF-1 binding sites, SF-209 and SF-98, in the promoter of the human ACTH receptor (hACTH-R) gene. Both sites, together with the previously described SF-35 site, are required for full constitutive activity of this gene. This was demonstrated by the use of constructs contain...

journal_title：Biochemical and biophysical research communications

authors： Naville D,Penhoat A,Durand P,Begeot M

更新日期：1999-02-05 00:00:00

abstract：:K+ channels are integral membrane proteins, which contribute to maintain vital parameters such as the cellular membrane potential and cell volume. Malaria parasites encode two K+ channel homologues, Kch1 and Kch2, which are well-conserved among members of the Plasmodium genus. In the rodent malaria parasite P. berghei...

journal_title：Biochemical and biophysical research communications

authors： Ellekvist P,Mlambo G,Kumar N,Klaerke DA

更新日期：2017-11-04 00:00:00

abstract：:It is found that secretion of pancreastatin and somatostatin from QGP-1N cells is regulated through muscarinic receptor-mediated activation of phosphatidylinositide hydrolysis system. In this report, whether the cAMP pathway interacts with the phosphoinositide turnover system for the secretion of pancreastatin and som...

journal_title：Biochemical and biophysical research communications

authors： Tateishi K,Funakoshi A,Kitayama N,Matsuoka Y

更新日期：1992-06-30 00:00:00

abstract：:The budding yeast Saccharomyces cerevisiae contains a single actin gene and the gene product, actin, is essential for growth. Two mutants of yeast actin that do not support yeast growth were prepared from yeast by coexpressing the mutant and a 6-histidine-tagged wild-type actin followed by separation of the wild-type ...

journal_title：Biochemical and biophysical research communications

authors： Frieden C,Du J,Schriefer L,Buzan J

更新日期：2000-05-10 00:00:00

abstract：:Oxidative stress contributes to tissue injury and cell death during the development of various diseases. The present study aims at investigating whether oxidative stress triggered by the exposure to hydrogen peroxide (H(2)O(2)) can induce apoptosis of induced pluripotent stem cells (iPS cells) in a mechanism mediated ...

journal_title：Biochemical and biophysical research communications

authors： Li Y,Shelat H,Geng YJ

更新日期：2012-10-05 00:00:00

abstract：:Xanthurenic acid is an endogenous molecule leading to caspase-9 and -3 activation. Here we report that xanthurenic acid targets signalling proteins 14-3-3 into lysosomes leading to interruption protein/protein interaction. Xanthurenic acid changed the localisation of 14-3-3 in the cells. At a concentration of 10 and 2...

journal_title：Biochemical and biophysical research communications

authors： Malina HZ,Frueh BE

更新日期：2003-10-17 00:00:00

abstract：:Osteogenic protein-1 (OP-1) is a member of the bone morphogenetic protein subfamily of the transforming growth factor-beta (TGF-beta) superfamily. Since members of the TGF-beta superfamily have a role in tissue development the distribution of OP-1 in developing human embryos (gestational age 5-14 weeks) was examined b...

journal_title：Biochemical and biophysical research communications

authors： Vukicevic S,Latin V,Chen P,Batorsky R,Reddi AH,Sampath TK

更新日期：1994-01-28 00:00:00

abstract：:Inflammation has been established in recent years as a hallmark of cancer. Cancer Associated Fibroblasts (CAFs) support tumorigenesis by stimulating angiogenesis, cancer cell proliferation and invasion. We previously demonstrated that CAFs also mediate tumor-enhancing inflammation in a mouse model of skin carcinoma. B...

journal_title：Biochemical and biophysical research communications

authors： Erez N,Glanz S,Raz Y,Avivi C,Barshack I

更新日期：2013-08-02 00:00:00

abstract：:Vibrio vulnificus, a halophilic estuarine bacterium causing a rapidly progressing fatal septicemia, is highly cytotoxic to eukaryotic cells. To identify new virulence factors associated with cytotoxicity, we constructed a mariner-based transposon (Tn Himar1) library of the highly virulent clinical isolate MO6-24/O hav...

journal_title：Biochemical and biophysical research communications

authors： Ran Kim Y,Haeng Rhee J

更新日期：2003-05-02 00:00:00

abstract：:KRAS is the key mutated gene in pancreatic ductal adenocarcinoma (PDAC). Emerging evidence indicates that KRas modulates endocytic uptake. The present study aimed to explore the fate of early endosomal trafficking under the control of KRas expression in PDAC. Surprisingly, PANC-1 cells lacking KRas exhibited significa...

journal_title：Biochemical and biophysical research communications

authors： Teske C,Schweitzer C,Palamidessi A,Aust DE,Scita G,Weitz J,Welsch T

更新日期：2017-11-04 00:00:00

abstract：:Complete nucleotide sequence of the genes for subunits of the H+ ATPase of E.coli has been determined and several hybrid plasmids carrying various portions of these genes have been constructed. Genetic complementation and recombination tests of about forty mutants of E.coli defective in the ATPase were performed using...

journal_title：Biochemical and biophysical research communications

authors： Noumi T,Kanazawa H

更新日期：1983-02-28 00:00:00

abstract：:Bovine bone marrow-derived macrophages (BBMM) were infected in vitro with a cytopathic (cp) and a noncytopathic (ncp) biotype of bovine viral diarrhea virus (BVDV). The virus strains used, TGAN (ncp) and TGAC (cp), originate from one animal and are antigenically closely related. Both TGAC and TGAN infected a subset of...

journal_title：Biochemical and biophysical research communications

authors： Adler H,Frech B,Meier P,Jungi TW,Peterhans E

更新日期：1994-08-15 00:00:00

abstract：:We have recorded multi-frequency EPR spectra of 63Cu- and 65Cu-labeled, water-soluble CuA-protein from the cytochrome ba3 of T. thermophilus. The spectrum taken at the highest frequency (34.03 GHz) shows no hyperfine structure and is nominally axial with apparent gz approximately 2.18 and gxy approximately 2.00. The s...

journal_title：Biochemical and biophysical research communications

authors： Fee JA,Sanders D,Slutter CE,Doan PE,Aasa R,Karpefors M,Vänngård T

更新日期：1995-07-06 00:00:00

abstract：BACKGROUND:Intestinal ischemia-reperfusion (I-R) injury is a serious abdominal condition leading to multiple organ failure with high mortality. However, no reliable treatment is available. A redox nanoparticle (RNPO) was recently developed, and its efficacy for several intestinal inflammatory conditions has been report...

journal_title：Biochemical and biophysical research communications

authors： Ueda T,Takagi T,Katada K,Iida T,Mizushima K,Dohi O,Okayama T,Yoshida N,Kamada K,Uchiyama K,Handa O,Ishikawa T,Konishi H,Naito Y,Nagasaki Y,Itoh Y

更新日期：2018-01-08 00:00:00

abstract：:Mitofusin1 (Mfn1) mediates outer mitochondrial membrane (OMM) fusion in Opisthokonts. The uncharacterized TM comprises to two helices (namely, the TM1 and TM2) connected by an intermembrane loop. Consistent with previous studies, our results from in silico analyses show that all mitofusins lack N terminal-MTS and the ...

journal_title：Biochemical and biophysical research communications

authors： Sinha S,Aradhyam GK

更新日期：2019-02-12 00:00:00

abstract：:MicroRNAs (miRNAs) are small noncoding RNAs that regulate target gene expression through translation repression or messenger RNA degradation. MiR-15a and 16-1 form a cluster at the chromosomal region 13q14, which is frequently deleted or down-regulated in chronic lymphocytic leukemia. Arsenic trioxide (As(2)O(3), ATO)...

journal_title：Biochemical and biophysical research communications

authors： Gao SM,Chen C,Wu J,Tan Y,Yu K,Xing CY,Ye A,Yin L,Jiang L

更新日期：2010-12-10 00:00:00

abstract：:Estrogens play an important role in the regulation of longitudinal bone growth in man, as demonstrated by recent descriptions of individuals with estrogen insensitivity or aromatase deficiency. Two estrogen receptors, ERalpha and ERbeta, have been cloned. The aim of the present study was to investigate the function of...

journal_title：Biochemical and biophysical research communications

authors： Vidal O,Lindberg M,Sävendahl L,Lubahn DB,Ritzen EM,Gustafsson JA,Ohlsson C

更新日期：1999-11-19 00:00:00

abstract：:This article has been withdrawn at the request of the editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Biochemical and biophysical research communications

authors： Gou X,Yang HA,He WY,Xiao MC,Wang M

更新日期：2010-05-10 00:00:00

abstract：:ARF-related protein 1 (ARFRP1) is a membrane-associated GTPase which inhibits the ARF/Sec7-dependent activation of phospholipase D. We have recently shown that deletion of Arfrp1 in mice results in increased apoptosis of mesodermal cells during gastrulation, leading to early embryonic lethality. Here we describe the o...

journal_title：Biochemical and biophysical research communications

authors： Mueller AG,Joost HG,Schürmann A

更新日期：2002-03-22 00:00:00

abstract：:Hematopoiesis is a complex process tightly controlled by sets of transcription factors in a context-dependent and stage-specific manner. Smad2/3 transcription factor plays a central role in differentiation and survival of erythroid cells. Here we report that follistatin-like 1 (FSTL1) treatment impairs hemin-induced e...

journal_title：Biochemical and biophysical research communications

authors： Wu J,Dong Y,Teng X,Cheng M,Shen Z,Chen W

更新日期：2015-10-30 00:00:00

abstract：:The anthrax lethal factor (LF) is a Zn(2+)-endopeptidase specific for mitogen-activated protein kinase kinases (MAPKKs), which are cleaved within their N-terminal region. Much line of effort was carried out to elucidate the catalytic activity of LF for designing the inhibitor and to understand the cellular mechanism o...

journal_title：Biochemical and biophysical research communications

authors： Kim J,Chai YG,Yoon MY

更新日期：2004-01-02 00:00:00

abstract：:The role of small ras homologous GTP-binding proteins in the regulation of smooth muscle contractility has become increasingly apparent but there is still little information about the presence of these proteins in human uterine smooth muscle. Messenger RNAs for p21-activated protein kinase isoforms (PAK1, PAK2, and PA...

journal_title：Biochemical and biophysical research communications

authors： Moore F,Da Silva C,Wilde JI,Smarason A,Watson SP,López Bernal A

更新日期：2000-03-16 00:00:00