当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Synergistic apoptosis induction in leukemic cells by miR-15a/16-1 and arsenic trioxide.

Synergistic apoptosis induction in leukemic cells by miR-15a/16-1 and arsenic trioxide.

Abstract：

:MicroRNAs (miRNAs) are small noncoding RNAs that regulate target gene expression through translation repression or messenger RNA degradation. MiR-15a and 16-1 form a cluster at the chromosomal region 13q14, which is frequently deleted or down-regulated in chronic lymphocytic leukemia. Arsenic trioxide (As(2)O(3), ATO) has been successfully applied to treat acute promyelocytic leukemia (APL). Its combination with other drugs presented therapeutic activities in hematologic and solid tumors. Here we investigated the potential synergy between miR-15a/16-1 and ATO on Bcr-Abl positive leukemic K562 cells. In this study, we found that combination of miR-15a/16-1 and ATO synergistically induced growth inhibition and apoptosis in K562 cells. The apoptosis, at least in part, through regulating mitochondrial function including the release of cytochrome c and loss of mitochondrial transmembrane potential, also activation of caspase-3 and degradation of poly-adenosine diphosphate-ribose polymerase. However, the expression of Bcr-Abl was not affected by ATO and/or miR-15a/16-1. Moreover, apoptotic synergy between miR-15a/16-1 and ATO was observed in Bcr-Abl negative leukemic cell lines and primary leukemic cells. Taken together, these findings suggested that the combined regiment of miR-15a/16-1 and ATO might be a potential therapeutic remedy for the treatment of leukemia.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Gao SM,Chen C,Wu J,Tan Y,Yu K,Xing CY,Ye A,Yin L,Jiang L

doi

10.1016/j.bbrc.2010.10.137

subject

Has Abstract

pub_date

2010-12-10 00:00:00

pages

203-8

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(10)02041-3

journal_volume

403

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Activation of bovine photoreceptor guanylate cyclase by S100 proteins.

    abstract：:S100 proteins are acidic calcium-binding proteins present in high concentration in the brain and at lower concentrations in peripheral tissues. Their function remains to be elucidated in many tissues. In this report we show for the first time that S100 proteins stimulate the bovine photoreceptor membrane guanylate cyc...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.0043

    authors： Margulis A,Pozdnyakov N,Sitaramayya A

    更新日期：1996-01-05 00:00:00

  • Peroxynitrite reacts with biological nitrogen-containing cyclic molecules by a radical pathway, as demonstrated by ultraweak luminescence coupled with ESR technique.

    abstract：:Ultraweak luminescence (uwCL) was coupled with electron spin resonance to study the reactions of 3 heterocyclic compounds (tryptophan, serotonin and imidazole) with peroxynitrite at pH 8.7. Tryptophan and serotonin reacted with emission of a flash peak of light (5 s) followed by a long-living light emission of +/- 80 ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.0805

    authors： Mouithys-Mickalad A,Kohnen S,Deby C,Noels AF,Lamy M,Deby-Dupont G

    更新日期：1999-06-07 00:00:00

  • Current perspectives of molecular pathways involved in chronic inflammation-mediated breast cancer.

    abstract：:Inflammation has multifaceted role in cancer progression including initiation, promotion and invasion by affecting the immune surveillance and associated signaling pathways. Inflammation facilitates the over-expression of cytokines, chemokines and growth factors involved in progression of different cancers including b...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章,评审

    doi：10.1016/j.bbrc.2015.10.133

    authors： Suman S,Sharma PK,Rai G,Mishra S,Arora D,Gupta P,Shukla Y

    更新日期：2016-04-08 00:00:00

  • Induction of allergic contact dermatitis by astigmatid mite-derived monoterpene, alpha-acaridial.

    abstract：:alpha-Acaridial [2(E)-(4-methyl-3-pentenyl)butenedial] is a novel monoterpene secreted from the house dust mites. Because of its molecular nature of a highly reactive, small lipidic compound, we addressed whether alpha-acaridial might function as a haptenic allergen that induced allergic contact dermatitis. Mice sensi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.07.148

    authors： Sasai T,Hirano Y,Maeda S,Matsunaga I,Otsuka A,Morita D,Nishida R,Nakayama H,Kuwahara Y,Sugita M,Mori N

    更新日期：2008-10-24 00:00:00

  • Hexadecane increases the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): is brown adipose tissue the primary target in TCDD-induced wasting syndrome?

    abstract：:Addition of 5% hexadecane to the diet of rats increased fecal excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) from 14 to 39% of an LD50 dose (60 micrograms/kg) during 10 days after dosing. This enhanced elimination did not result in reduced toxicity. On the contrary, the treatment has increased mortality from ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(84)91382-2

    authors： Rozman K

    更新日期：1984-12-28 00:00:00

  • Sequence specific binding of Ets-1 to the mouse cytokeratin EndoA gene enhancer.

    abstract：:Expression of the mouse cytokeratin EndoA gene is regulated by an enhancer that is located 1 kilobases (kb) 3' downstream from the gene. The EndoA enhancer consists of six direct repeats with homology to the PEA3 motif in the polyoma virus enhancer core. The PEA3 motif binds to the proto-oncogene Ets product. In this ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.1433

    authors： Hamazato F,Fujimura Y,Tamai Y,Takemoto Y,Matsushiro A,Nozaki M

    更新日期：1993-04-30 00:00:00

  • Development of xeno-free epithelial differentiation media for adherent, non-expanded adipose stromal vascular cell cultures.

    abstract：INTRODUCTION:Reconstruction of respiratory epithelium is critical for the fabrication of bioengineered airway implants. Epithelial differentiation is typically achieved using bovine pituitary extract (BPE). Due to the xenogenic nature and undefined composition of BPE, an alternative for human clinical applications, dev...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.08.104

    authors： Hintze JM,Tchoukalova YD,Sista R,Shah MK,Zhang N,Lott DG

    更新日期：2018-09-18 00:00:00

  • A pungent ingredient of mustard, allylisothiocyanate, inhibits (H+ + K+)-ATPase.

    abstract：:Allylisothiocyanate (ANCS) is shown to inhibit (H+ + K+)-ATPase isolated from the parietal cell of hog gastric mucosa. The ATPase is the proton pump in the secretory membrane of the parietal cell and is an essential component of the acid secretory mechanism. Furthermore, ANCS suppresses acid secretion by bullfrog gast...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(83)91487-0

    authors： Takeguchi N,Nishimura Y,Watanabe T,Mori Y,Morii M

    更新日期：1983-04-29 00:00:00

  • The incipient stage in thrombin-induced fibrin polymerization detected by FCS at the single molecule level.

    abstract：:We used fluorescence correlation spectroscopy (FCS) to study the activation of fibrinogen by thrombin and the subsequent aggregation of fibrin monomers into fibrin polymers at a very low and at physiological fibrinogen concentrations. In the labeling procedure used the fibrinogen was randomly labeled and the label was...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.0850

    authors： Bark N,Földes-Papp Z,Rigler R

    更新日期：1999-06-24 00:00:00

  • Metabolism of the mutagen MeIQx in vivo: metabolite screening by liquid chromatography-thermospray mass spectrometry.

    abstract：:2-Amino-3,8-dimethylimidazo(4,5-f)quinoxaline (MeIQx) is a potent mutagen found in cooked food. MeIQx and its isotopically labelled (13C, 15N2 and 14C) analogues were synthesised and used for metabolic studies in vivo. An equimolar mixture of MeIQx and its 13C, 15N2 stable isotope labelled analogue (containing tracer ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(87)80284-x

    authors： Gooderham NJ,Watson D,Rice JC,Murray S,Taylor GW,Davies DS

    更新日期：1987-11-13 00:00:00

  • Increased expression of caveolin-1 in heterozygous Niemann-Pick type II human fibroblasts.

    abstract：:Human Niemann-Pick type II fibroblasts, which encompass the panethnic type C (NPC) and Nova Scotia Acadian type D (NPD) variants, exhibit altered expression of caveolin-1 protein when examined by immunoblotting using an anti-caveolin-1 monoclonal antibody. Unexpectedly, caveolin-1 in heterozygous fibroblasts was signi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1997.6929

    authors： Garver WS,Hsu SC,Erickson RP,Greer WL,Byers DM,Heidenreich RA

    更新日期：1997-07-09 00:00:00

  • Angiotensin II inhibitory peptide found in the receptor sequence using peptide array.

    abstract：:Peptide array consisting of hundreds of peptides spatially addressed and synthesized on a cellulose membrane support was used to screen ligand-inhibitory peptides. As a model, angiotensin II (Ang II), a significant peptide related to the treatment of cardiovascular diseases, was chosen as the target ligand. Peptide ar...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.01.016

    authors： Kato R,Kunimatsu M,Fujimoto S,Kobayashi T,Honda H

    更新日期：2004-02-27 00:00:00

  • A histone 1-like antigen is a component of the nuclear envelope.

    abstract：:Rabbit antibodies have been raised against rat liver nuclear envelopes. An enzyme-linked immunosorbent assay (ELISA) demonstrated high titer antiserum specific for the nuclear envelope preparation. Immunocytochemical studies showed that the antiserum stained the nuclear envelopes, but not intra-nuclear components of H...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(88)80895-7

    authors： Venkatraman JT,Gohill J,Fritzler MJ,Lefebvre YA

    更新日期：1988-10-31 00:00:00

  • Effect of ionomycin on cell pH in isolated renal proximal tubules.

    abstract：:In isolated rabbit proximal tubules the addition of 2.0 microM but not 0.2 microM ionomycin induced a sustained increase in cell pH ([pH]i). This [pH]i response to 2.0 microM ionomycin was shown to be independent of several transporters such as Na+/H+ exchanger, Na(+)-HCO3- cotransporter, Cl-/HCO3- exchanger, or H(+)-...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.1156

    authors： Yamada H,Seki G,Taniguchi S,Uwatoko S,Suzuki K,Kurokawa K

    更新日期：1996-08-05 00:00:00

  • A lentiviral vector with novel multiple cloning sites: stable transgene expression in vitro and in vivo.

    abstract：:Gene delivery has become an important tool for biological research and gene therapy trials. Lentiviral vector (LV) mediated gene transfer is a preferred approach for stable, sustained transgenic expression. We report here step-wise development of an Indian human immunodeficiency virus type 2 (HIV-2) isolate derived th...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.04.106

    authors： Santhosh CV,Tamhane MC,Kamat RH,Patel VV,Mukhopadhyaya R

    更新日期：2008-07-04 00:00:00

  • Folate-modified PLGA nanoparticles for tumor-targeted delivery of pheophorbide a in vivo.

    abstract：:Targeted drug delivery has been an important issue for tumor therapy including photodynamic therapy (PDT). The purpose of our study is to increase the targeting efficiency of photosensitizer (PS) using folate-modified nanoparticles (NPs) to tumor site in vivo. Folate receptor is over-expressed on the surface of many h...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.03.013

    authors： Son J,Yang SM,Yi G,Roh YJ,Park H,Park JM,Choi MG,Koo H

    更新日期：2018-04-06 00:00:00

  • Defective GATA-3 expression in Th2 LCR-deficient mice.

    abstract：:Th2 cell differentiation is critically influenced by transcription factor GATA-3 and by various cis-acting elements including enhancers, silencers and a locus control region (LCR) in the Th2 cytokine locus. Th2 LCR-deficient Th2 cells completely lost the expression of GATA-3 and the phosphorylation of STAT6. Histone 3...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.06.080

    authors： Hwang SS,Kim K,Lee GR

    更新日期：2011-07-15 00:00:00

  • Tetraphenylborate potentiates the respiratory inhibition by the dopaminergic neurotoxin MPP+ in both electron transport particles and intact mitochondria.

    abstract：:The cytotoxicity of 1-methyl-4-phenylpyridinium (MPP+) is believed to arise as a consequence of its time- and energy-dependent accumulation inside mitochondria, followed by inhibition of electron transport at Complex I of the respiratory chain. Consistent with our proposal that the accumulation of MPP+ represents a pa...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(89)92672-7

    authors： Sayre LM,Wang F,Hoppel CL

    更新日期：1989-06-15 00:00:00

  • Expression of the fetal-oncogenic fibroblast growth factor-8/17/18 subfamily in human hematopoietic tumors.

    abstract：:The fibroblast growth factors (FGFs) are involved in hematopoiesis and tumorigenesis. However, little is known about the contribution of the FGFs identified within the past 10 years to leukemogenesis. To elucidate whether these FGFs (FGF-8, -9, -10, -11, -12, -13, -14, -16, -17, -18, -19, -20, and -21) are expressed i...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.07.153

    authors： Nezu M,Tomonaga T,Sakai C,Ishii A,Itoga S,Nishimura M,Matsuo Y,Tagawa M,Nomura F

    更新日期：2005-09-30 00:00:00

  • The l-isoform but not d-isoforms of a JNK inhibitory peptide protects pancreatic beta-cells.

    abstract：:The activation of c-jun N-terminal kinase (JNK) in pancreatic islets is associated with impaired function and viability, and JNK inhibitory peptides (JNKIs) are cytoprotective. In particular, l-isoforms of JNKIs were shown to improve islets viability, while the d-retroinverso isoform of JNKI (RI-JNKI), with a higher t...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.12.186

    authors： Fornoni A,Cobianchi L,Sanabria NY,Pileggi A,Molano RD,Ichii H,Rosero S,Inverardi L,Ricordi C,Pastori RL

    更新日期：2007-03-02 00:00:00

  • Wnt/β-catenin pathway mediates (-)-Epigallocatechin-3-gallate (EGCG) inhibition of lung cancer stem cells.

    abstract：:Cancer stem cells (CSCs) play essential role in the progression of many tumors. Wnt/β-catenin pathway is crucial in maintaining the stemness of CSCs. (-)-Epigallocatechin-3-gallate (EGCG), the major bioactive component in green tea, has been shown to possess anti-cancer activity. To date, the interventional effect of ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.11.038

    authors： Zhu J,Jiang Y,Yang X,Wang S,Xie C,Li X,Li Y,Chen Y,Wang X,Meng Y,Zhu M,Wu R,Huang C,Ma X,Geng S,Wu J,Zhong C

    更新日期：2017-01-01 00:00:00

  • Zyxin is up-regulated during megakaryocytic differentiation of human UT-7/c-mpl cells.

    abstract：:To characterize genes involved in megakaryocytic commitment, we compared expression profiles of bipotent cells (UT-7/c-mpl) with those of the same cells induced to differentiate towards megakaryopoiesis in the presence of TPO. Using cDNA arrays, we showed that 12 out of 2260 genes changed their expression level after ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.04.047

    authors： Decraene C,Garçon L,Lacout C,Sabri S,Auffray C,Vainchenker W,Duménil D,Piétu G,Svinartchuk F

    更新日期：2004-05-28 00:00:00

  • Retinoic acid signaling regulates embryonic clock hairy2 gene expression in the developing chick limb.

    abstract：:Embryo development proceeds under strict temporal control and an embryonic molecular clock (EC), evidenced by cyclic gene expression, is operating during somite formation and limb development, providing temporal information to precursor cells. In somite precursor cells, EC gene expression and periodicity depends on Re...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.06.077

    authors： Sheeba CJ,Palmeirim I,Andrade RP

    更新日期：2012-07-13 00:00:00

  • The BRCC3 regulated by Cdk5 promotes the activation of neuronal NLRP3 inflammasome in Parkinson's disease models.

    abstract：:BRCA1-BRCA2-containing complex subunit 3 (BRCC3), a Lys-63-specific deubiquitinase, is a member of the JAMM/MPN family of zinc metalloproteases. BRCC3 have been shown to promote the inflammasome activation by deubiquitinating NOD-like receptor containing pyrin domain 3 (NLRP3). We reported the involvement of neuronal ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.11.141

    authors： Cheng X,Xu S,Zhang C,Qin K,Yan J,Shao X

    更新日期：2020-02-12 00:00:00

  • A new fluorescence-based method to monitor the pH in the thylakoid lumen using GFP variants.

    abstract：:The ΔpH-dependent/Tat pathway is unique for using only the proton motive force for driving proteins transport across the thylakoid membrane in chloroplasts. 9-aminoacridine fluorescence quenching is widely used to monitor the ΔpH developed across the thylakoid membrane in the light. However, this method suffers from l...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.12.032

    authors： Yang H,Pu X,Wang L,Liu L,Theg SM

    更新日期：2017-04-22 00:00:00

  • Involvement of activation of PLIN5-Sirt1 axis in protective effect of glycycoumarin on hepatic lipotoxicity.

    abstract：:Licorice is a popular medicinal plant, and it has been used to treat various diseases, including liver diseases. Glycycoumarin (GCM) is a major coumarin compound isolated from licorice with favorable bioavailability property. Our previous studies have shown that GCM is capable of inhibiting lipoapoptosis in both cell ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.05.072

    authors： Zhang E,Yin S,Zhao C,Fan L,Hu H

    更新日期：2020-07-12 00:00:00

  • Remodeling of ion channel expression may contribute to electrophysiological consequences caused by methamphetamine in vitro and in vivo.

    abstract：:Methamphetamine (MA) is a psychostimulant. MA may induce numerous cardiotoxic effects, leading to cardiac arrhythmias, heart failure, eventually leading to sudden cardiac death. The deleterious effects of methamphetamine work in tandem to disrupt the coordinated electrical activity of the heart and have been associate...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.11.114

    authors： Qu YH,Leung KP,Qiao DF,Li DR,Liu C,Yue X,Wang HJ

    更新日期：2014-01-10 00:00:00

  • Rapid heat production associated with excitation of electric organs of the electric eel.

    abstract：:By constructing a new type of thermal detector, rapid production of heat was demonstrated during the rising phase of the action potential of the eel electric organs evoked by direct electric stimulation. Following the indirect (synapse-mediated) action potential of the organs, the existence of very large and variable ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.2565

    authors： Tasaki I,Byrne PM

    更新日期：1993-12-15 00:00:00

  • The SH2 domain containing inositol 5-phosphatase SHIP2 controls phosphatidylinositol 3,4,5-trisphosphate levels in CHO-IR cells stimulated by insulin.

    abstract：:The lipid phosphatase SHIP2 (SH2 domain containing inositol 5-phosphatase 2) has recently been shown to be a potent negative regulator of insulin signaling and insulin sensitivity in vivo. We show here that SHIP2 is expressed in Chinese hamster ovary cells overexpressing the insulin receptor (CHO-IR cells) and tyrosin...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.4639

    authors： Blero D,De Smedt F,Pesesse X,Paternotte N,Moreau C,Payrastre B,Erneux C

    更新日期：2001-04-06 00:00:00

  • Epidermal growth factor inhibits both cholecystokinin octapeptide-induced inositol 1,4,5-trisphosphate production and [CA2+]i increase in rat pancreatic acinar cells.

    abstract：:We have studied the effects of epidermal growth factor (EGF) on both cholecystokinin octapeptide (CCK-OP)-induced inositol-1,4,5 trisphosphate (IP3) production and on cytosolic free calcium concentrations [Ca2+]i by fluorescence measurements in fura-2-loaded pancreatic acini. Our data show that EGF inhibits CCK-OP ind...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(05)81150-7

    authors： Pröfrock A,Piiper A,Eckhardt L,Schulz I

    更新日期：1991-10-31 00:00:00