The BRCC3 regulated by Cdk5 promotes the activation of neuronal NLRP3 inflammasome in Parkinson's disease models.

abstract：:This study defines the total sodium-23 magnetic resonance spectroscopy (23Na MRS) signal from in vivo heterotopic rat heart transplants in the early post-transplant period and examines the utility of this noninvasive method for monitoring allograft rejection. Measurements were performed at 4.7 T. Syngeneic (n = 6) and...

journal_title：Biochemical and biophysical research communications

authors： Waldrop SM,Alexander DZ,Lowry R,Winn KJ,Pearson TC,Constantinidis I

更新日期：1996-06-14 00:00:00

abstract：:The ocr protein of bacteriophage T7 is a structural and electrostatic mimic of approximately 24 base pairs of double-stranded B-form DNA. As such, it inhibits all Type I restriction and modification (R/M) enzymes by blocking their DNA binding grooves and inactivates them. This allows the infection of the bacterial cel...

journal_title：Biochemical and biophysical research communications

authors： Stephanou AS,Roberts GA,Tock MR,Pritchard EH,Turkington R,Nutley M,Cooper A,Dryden DT

更新日期：2009-01-02 00:00:00

abstract：:The hereditary renal carcinoma (RC) in the rat, originally reported by R. Eker in 1954, is an excellent example of a Mendelian dominantly inherited predisposition to a specific cancer in an experimental animal. Recently, we have identified a germline mutation of the sclerosis (Tsc2) gene in the Eker rat (Nature Geneti...

journal_title：Biochemical and biophysical research communications

authors： Orimoto K,Tsuchiya H,Kobayashi T,Matsuda T,Hino O

更新日期：1996-02-06 00:00:00

abstract：:The mechanism and target genes of regulation by Forkhead (FHA) domain-containing transcription factors have not yet been documented in Archaea. In this study, using a bacterial one-hybrid technique, we successfully screened and identified for the first time a target gene regulated by ST0829, an FHA domain-containing p...

journal_title：Biochemical and biophysical research communications

authors： Duan X,He ZG

更新日期：2011-04-01 00:00:00

abstract：:We constructed a system for expressing the Fab of the therapeutic human monoclonal antibody adalimumab at a yield of 20 mg/L in the methylotrophic yeast Pichia pastoris. To examine the contribution of interchain disulfide bonds to conformational stability, we prepared adalimumab Fab from which the interchain disulfide...

journal_title：Biochemical and biophysical research communications

authors： Nakamura H,Oda-Ueda N,Ueda T,Ohkuri T

更新日期：2018-01-01 00:00:00

abstract：:The expression of mouse CYP27B1 in Escherichia coli has been dramatically enhanced by coexpression of GroEL/ES. To reveal the enzymatic properties of CYP27B1, we measured its hydroxylation activity toward vitamin D3 and 1alpha-hydroxyvitamin D3 (1alpha(OH)D3) in addition to the physiological substrate 25(OH)D3. Surpri...

journal_title：Biochemical and biophysical research communications

authors： Uchida E,Kagawa N,Sakaki T,Urushino N,Sawada N,Kamakura M,Ohta M,Kato S,Inouye K

更新日期：2004-10-15 00:00:00

abstract：:Liraglutide, a glucagon-like peptide 1 (GLP-1) analogue, could reverse NAFLD-induced liver damage by improving metabolic profiles, but the exact molecular mechanism has not been elucidated. Sestrin2 is a novel antioxidant protein, essential for regulating metabolic homeostasis. However, whether sestrin2-mediated redox...

journal_title：Biochemical and biophysical research communications

authors： Han X,Ding C,Zhang G,Pan R,Liu Y,Huang N,Hou N,Han F,Xu W,Sun X

更新日期：2020-05-14 00:00:00

abstract：:We report here on the cloning and functional characterization of human LAT1, a subunit of the amino acid transport system L. The hLAT1 cDNA, obtained from a human placental cDNA library, codes for a protein of 507 amino acids. When functionally expressed in mammalian cells together with the heavy chain of the rat 4F2 ...

journal_title：Biochemical and biophysical research communications

authors： Prasad PD,Wang H,Huang W,Kekuda R,Rajan DP,Leibach FH,Ganapathy V

更新日期：1999-02-16 00:00:00

abstract：:Potassium tellurite (K(2)TeO(3)) is harmful to most organisms and specific mechanisms explaining its toxicity are not well known to date. We previously reported that the lpdA gene product of the tellurite-resistant environmental isolate Aeromonas caviae ST is involved in the reduction of tellurite to elemental telluri...

journal_title：Biochemical and biophysical research communications

authors： Castro ME,Molina RC,Díaz WA,Pradenas GA,Vásquez CC

更新日期：2009-02-27 00:00:00

abstract：:Acute respiratory distress syndrome (ARDS) is associated with high mortality and morbidity. Early diagnosis and risk stratification in patients with ARDS should improve prognosis. Unfortunately, no clinical biomarkers are available for use in early diagnosis. Quantitative proteomics is a powerful tool for biomarker di...

journal_title：Biochemical and biophysical research communications

authors： Ren S,Chen X,Jiang L,Zhu B,Jiang Q,Xi X

更新日期：2016-09-23 00:00:00

abstract：:To examine the possibility that the Orf135 protein of Escherichia coli functions as a hydrolyzing enzyme for a damaged DNA precursor (deoxyribonucleoside 5'-triphosphate), we purified the recombinant Orf135 protein and incubated it with oxidized deoxynucleotides. Of the nucleotides tested, 2-hydroxydeoxyadenosine 5'-t...

journal_title：Biochemical and biophysical research communications

authors： Kamiya H,Murata-Kamiya N,Iida E,Harashima H

更新日期：2001-11-02 00:00:00

abstract：:A baculovirus expression system has been used to express large quantities of full-length, biologically active Xenopus fibroblast growth factor receptor-1. Recombinant XFGFR-1 was purified to near homogeneity by a single step immunoaffinity purification procedure. The recombinant XFGFR-1 binds both FGF-1 and FGF-2 with...

journal_title：Biochemical and biophysical research communications

authors： Brown SA,Friesel R

更新日期：1993-06-30 00:00:00

abstract：:Hydrophobic modifications of transducin (T) gamma, such as farnesyl-and carboxyl-methylation, are essential for the association of T beta gamma with the photoreceptor disc membrane, and MEKA/phosducin is known to inhibit the association. In this study, we examined the effect of MEKA on the hydrophobicity of T beta gam...

journal_title：Biochemical and biophysical research communications

authors： Tanaka H,Kuo CH,Matsuda T,Fukada Y,Hayashi F,Ding Y,Irie Y,Miki N

更新日期：1996-06-25 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a potent and specific mitogen for vascular endothelial cells. A 3.9 kb VEGF transcript is expressed by all cardiac tissues from rat, mouse and guinea pig examined. VEGF expression was not developmentally regulated. The major form of VEGF mRNAs expressed by cardiac tissues c...

journal_title：Biochemical and biophysical research communications

authors： Ladoux A,Frelin C

更新日期：1993-09-15 00:00:00

abstract：:Baeyer-Villiger monooxygenase (BVMO) catalyzes insertion of an oxygen atom into aliphatic or cyclic ketones with high regioselectivity. The BVMOs from Parvibaculum lavamentivorans (BVMOParvi) and Oceanicola batsensis (BVMOOcean) are interesting because of their homologies, with >40% sequence identity, and reaction wit...

journal_title：Biochemical and biophysical research communications

authors： Nguyen TD,Choi GE,Gu DH,Seo PW,Kim JW,Park JB,Kim JS

更新日期：2019-05-07 00:00:00

abstract：:We have characterized a novel surface protein from urea extract of whole cells of group A Streptococcus pyogenes (GAS). A major protein band (35kD) was found to hybridize with human IgG by Western blotting. A search of the N-terminal amino acid sequence of this protein by using the GAS genome sequence database reveale...

journal_title：Biochemical and biophysical research communications

authors： Kawabata S,Tamura Y,Murakami J,Terao Y,Nakagawa I,Hamada S

更新日期：2002-09-06 00:00:00

abstract：:Employing RNA gel mobility shift assays we detected specific binding events between several dehydrogenases and various regions of the GLUT1 mRNA 3'-untranslated region. In particular, the enzymes glyceraldehyde 3-phosphate dehydrogenase (G3PDH), lactate dehydrogenase (LDH), and glucose 6-phosphate dehydrogenase (G6PDH...

journal_title：Biochemical and biophysical research communications

authors： McGowan K,Pekala PH

更新日期：1996-04-05 00:00:00

abstract：:Tyrosine kinase inhibitors (TKIs) exert potent therapeutic efficacy in non-small cell lung cancers (NSCLC) harboring epidermal growth factor receptor (EGFR) activating mutations. However, a major impediment for the effective treatment is the development of drug resistance. Some evidence supports a role for miRNAs in m...

journal_title：Biochemical and biophysical research communications

authors： Ping W,Gao Y,Fan X,Li W,Deng Y,Fu X

更新日期：2018-01-22 00:00:00

abstract：:The long-sought three-dimensional structure of the M2 proton channel of influenza A virus was successfully determined recently by the high-resolution NMR [J.R. Schnell, J.J. Chou, Structure and mechanism of the M2 proton channel of influenza A virus, Nature 451 (2008) 591-595]. Such a milestone work has provided a sol...

journal_title：Biochemical and biophysical research communications

authors： Huang RB,Du QS,Wang CH,Chou KC

更新日期：2008-12-26 00:00:00

abstract：:Three dnaK gene homologs have been cloned and sequenced from cyanobacterium Synechococcus sp. PCC7942 using a set of primers designed from two conserved regions of known dnaK genes. This is the first example of triple genes for dnaK from prokaryotic cells. These three genes were derived from different loci of the chro...

journal_title：Biochemical and biophysical research communications

authors： Nimura K,Yoshikawa H,Takahashi H

更新日期：1994-05-30 00:00:00

abstract：:The downregulation of gene expression by RNA interference holds great potential for genetic analysis and gene therapy. However, a more efficient delivery system for small interfering RNA (siRNA) into the target cells is required for wide fields such as cell biology, physiology, and clinical application. Non-viral vect...

journal_title：Biochemical and biophysical research communications

authors： Inoh Y,Furuno T,Hirashima N,Kitamoto D,Nakanishi M

更新日期：2011-10-28 00:00:00

abstract：:Exposure of mesangial cells to ionic Cd(2+) induces the proto-oncogene c-fos, while activating both Erk and stress-activated protein kinase (SAPK) MAP kinase pathways. While we have previously used a pharmacological inhibitor of Erk activation to implicate involvement of this pathway in the induction of c-fos by Cd(2+...

journal_title：Biochemical and biophysical research communications

authors： Ding W,Templeton DM

更新日期：2000-07-05 00:00:00

abstract：:The Rv2477c protein of Mycobacterium tuberculosis (Mtb) belongs to the ATP-binding cassette (ABC) subfamily F that contains proteins with tandem nucleotide-binding domains but lacking transmembrane domains. ABC-F subfamily proteins have been implicated in diverse cellular processes such as translation, antibiotic resi...

journal_title：Biochemical and biophysical research communications

authors： Daniel J,Abraham L,Martin A,Pablo X,Reyes S

更新日期：2018-01-01 00:00:00

abstract：:A bovine brain calmodulin-dependent protein kinase undergoes autophosphorylation with a maximal incorporation of 10 mol phosphate per mol enzyme. The autophosphorylated enzyme is fully active, independent of Ca2+ and calmodulin. Although the autophosphorylation reaction depends on Ca2+ and calmodulin, it can be render...

journal_title：Biochemical and biophysical research communications

authors： Zhang GY,Wang JH,Sharma RK

更新日期：1993-03-15 00:00:00

abstract：:The discovery of small molecule kinase inhibitors for use as drugs is a promising approach for the treatment of cancer and other diseases, but the discovery of highly specific agents is challenging because over 850 kinases are expressed in mammalian cells. Systematic modification of the 4-anilino functionality of a se...

journal_title：Biochemical and biophysical research communications

authors： Bhattacharya SK,Cox ED,Kath JC,Mathiowetz AM,Morris J,Moyer JD,Pustilnik LR,Rafidi K,Richter DT,Su C,Wessel MD

更新日期：2003-07-25 00:00:00

abstract：:The products of the human hepatitis B virus (HBV) and woodchuck hepatitis B virus X genes (pXs) transactivate homologous and heterologous genes including the HBV-X and core promoters, the human immunodeficiency viruses 1 (HIV-1) and 2 (HIV-2) long terminal repeats and the beta interferon regulatory sequences. We repor...

journal_title：Biochemical and biophysical research communications

authors： Balsano C,Avantaggiati ML,Natoli G,De Marzio E,Will H,Perricaudet M,Levrero M

更新日期：1991-05-15 00:00:00

abstract：:The reaction of peroxynitrite anion (O=N-OO-) with CO2 results in the formation of an unstable nitrosoperoxycarbonate anion adduct, O=N-OOCO-2 (1). Adduct 1 can serve as a source for several reactive intermediates, including the nitrocarbonate anion (O2N-OCO-2), the carbonate radical ion/nitrogen dioxide radical pair,...

journal_title：Biochemical and biophysical research communications

authors： Uppu RM,Pryor WA

更新日期：1996-12-24 00:00:00

abstract：:The aims of this study are to identify the sex steroid-metabolizing cytochrome P450 enzymes of the vomeronasal organ (VNO) and to determine the activities of VNO microsomes to metabolize estradiol, progesterone, and testosterone. Several P450 isoforms, including CYP1A2, CYP2A, CYP2B, CYP2C, CYP2G1, and CYP3A, NADPH P4...

journal_title：Biochemical and biophysical research communications

authors： Gu J,Dudley C,Su T,Spink DC,Zhang QY,Moss RL,Ding X

更新日期：1999-12-09 00:00:00

abstract：:Interstitial fibrosis and loss of parenchymal tubular cells are the common outcomes of progressive renal diseases. Pro-inflammatory cytokines have been known contributing to the damage of tubular cells and fibrosis responses after renal injury. Interleukin (IL)-33 is a tissue-derived nucleus alarmin that drives inflam...

journal_title：Biochemical and biophysical research communications

authors： Chen WY,Chang YJ,Su CH,Tsai TH,Chen SD,Hsing CH,Yang JL

更新日期：2016-05-13 00:00:00

abstract：:Celiptium, a cationic and amphiphilic drug currently employed in cancer chemotherapy, was found to be accumulated against its concentration gradient by the bacterium Streptococcus pneumoniae. Accumulation was reduced in Celiptium resistant amiA mutants which were also observed to have reduced electric transmembrane po...

journal_title：Biochemical and biophysical research communications

authors： Sautereau AM,Tocanne JF,Trombe MC

更新日期：1987-06-15 00:00:00