Effect of ionomycin on cell pH in isolated renal proximal tubules.

abstract：:Glycoprotein130 (gp130) is an important signal transducer in the interleukin-6 (IL-6) trans-signaling pathway, which plays a crucial role in chronic inflammation in atherosclerosis. Studies suggest that estrogen can inhibit IL-6/gp130 signaling and reduce the risk of coronary artery disease, but the precise mechanism ...

journal_title：Biochemical and biophysical research communications

authors： Zhou M,Dai W,Cui Y,Li Y

更新日期：2020-03-12 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) is a cytokine important in inducing epithelial-mesenchymal transition (EMT), a crucial morphological event in a wide range of physiological and pathological cellular processes. In this study, we demonstrate that TGF-beta1 induces the EMT phenotype through decreasing the expre...

journal_title：Biochemical and biophysical research communications

authors： Lee EK,Jeon WK,Chae MY,Hong HY,Lee YS,Kim JH,Kwon JY,Kim BC,Park SH

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND/AIMS:TEC, a member of the TEC family of non-receptor type protein tyrosine kinases, has recently been suggested to play a role in hepatocyte proliferation and liver regeneration. This study aims to investigate the putative mechanisms of TEC kinase regulation of hepatocyte differentiation, i.e. to explore whi...

journal_title：Biochemical and biophysical research communications

authors： Li F,Jiang Y,Zheng Q,Yang X,Wang S

更新日期：2011-01-07 00:00:00

abstract：:Protein-binding DNA-regions inside and in the vicinity of the phenobarbital-inducible P450bm-3 gene from Bacillus megaterium were characterized by gel-retardation technique and foot-printing analysis. Regions with induction-dependent protein binding capacity were shown to be situated in -279bp/-215bp, -215bp/+83bp and...

journal_title：Biochemical and biophysical research communications

authors： Gaidamakova EK,Karginov VA,Kovalenko SP

更新日期：1994-02-15 00:00:00

abstract：:Chloroperoxidase was present as Compound II during the peroxidatic oxidation of ascorbic acid. Compound III (oxy-form) was formed when excess hydrogen peroxide was added to Compound II. By decreasing the temperature it was possible to measure the spectra of Compounds II and III in the Soret and visible regions. Each s...

journal_title：Biochemical and biophysical research communications

authors： Nakajima R,Yamazaki I,Griffin BW

更新日期：1985-04-16 00:00:00

abstract：:Number and molecular Brightness (N&B) analysis is a powerful method used to monitor protein aggregation in living cells. Here, we used the N&B method to characterize the unexpanded HTT protein oligomerization after the internalization of the mutant HTT (mHTT) which contains a CAG repeat extensions encoding for long po...

journal_title：Biochemical and biophysical research communications

authors： Sameni S,Zhang R,Digman MA

更新日期：2020-01-29 00:00:00

abstract：AIMS:diabetes mellitus is one of the most common metabolic diseases worldwide characterized by insulin resistance and pancreatic β cell dysfunction. miRNA plays an important role in DM. In previous studies, miRNA-92a could function as targets for innovative precision medicines to reduce T1D islet autoimmunity. However,...

journal_title：Biochemical and biophysical research communications

authors： Wang W,Wang J,Yan M,Jiang J,Bian A

更新日期：2018-06-07 00:00:00

abstract：:Neural crest cells originating from the posterior rhombencephalon migrate to the cardiac outflow tract and participate in division of the aorta and pulmonary trunk. Ablation of this region of premigratory neural crest in the chick embryos results in nondivision of the outflow vessels. Subtractive hybridization was use...

journal_title：Biochemical and biophysical research communications

authors： Kirby ML,Cheng G,Stadt H,Hunter G

更新日期：1995-07-17 00:00:00

abstract：:The new bacterial vector pETM60 enables the expression of His-tagged recombinant proteins fused to the C-terminus of NusA through a TEV protease recognition sequence. Three sequences coding for two protein domains (Xklp3A and Tep3Ag) and one membrane-bound viral protein (E8R) could not be expressed in a soluble form i...

journal_title：Biochemical and biophysical research communications

authors： De Marco V,Stier G,Blandin S,de Marco A

更新日期：2004-09-24 00:00:00

abstract：:Ca2+ channels are involved in the regulation of vascular functions. Angiotensin II is implicated in the development of atherosclerosis and vascular remodeling. In this study, we demonstrated that angiotensin II preferentially increased the expression of alpha1G, a T-type Ca2+ channel subunit, via AT1 receptors in endo...

journal_title：Biochemical and biophysical research communications

authors： Wang D,Hirase T,Inoue T,Node K

更新日期：2006-08-25 00:00:00

abstract：:This article has been withdrawn at the request of the author. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Biochemical and biophysical research communications

authors： Seong ES,Cho HS,Choi D,Joung YH,Lim CK,Hur JH,Wang MH

更新日期：2007-11-21 00:00:00

abstract：:Endothelial cells participate in the inflammatory and immune reactions. Endothelial cell activation is a recurrent phenomenon linked to the pathogenesis of diverse human diseases, such as acute and chronic inflammation and cardiovascular disorders. Pro-inflammatory cytokines (e.g., IL-1, TNF) are well-known activators...

journal_title：Biochemical and biophysical research communications

authors： Takehana K,Konishi A,Oonuki A,Noguchi M,Fujita K,Iino Y,Kobayashi T

更新日期：2002-05-10 00:00:00

abstract：:The thyroid hormone receptor alpha gene is alternatively spliced to give the alpha receptor and a variant which does not bind thyroid hormones. An additional alpha-like receptor (Rev-erbA alpha) is transcribed on the opposite strand and overlaps the unique variant sequence. The alpha receptor in rat brain reaches peak...

journal_title：Biochemical and biophysical research communications

authors： Jannini EA,Mitsuhashi T,Nikodem VM

更新日期：1992-04-30 00:00:00

abstract：:Global rise in obesity at early age due to overconsumption of energy-dense food is the major health problem which increases the exposure to obesity over longer duration. Recently we reported that the severity of ovarian dysfunction depends on the duration of obesity. In the present study, we examined the consequences ...

journal_title：Biochemical and biophysical research communications

authors： Kannan S,Bhaskaran RS

更新日期：2019-11-12 00:00:00

abstract：:Inflammation has been postulated as a risk factor for several cancers. 3-Nitrotyrosine is a biochemical marker for inflammation. We investigated the ability of nitrotyrosine and nitrotyrosine-containing peptides (nitroY-peptide) to induce DNA damage by the experiments using 32P-labeled DNA fragments obtained from the ...

journal_title：Biochemical and biophysical research communications

authors： Murata M,Kawanishi S

更新日期：2004-03-26 00:00:00

abstract：OBJECTIVE:We have recently identified an activation site on (Na+ + K+)-ATPase and found that binding of antibody SSA412 to this specific site of the enzyme markedly augments (Na+ + K+)-ATPase catalytic activity. Demonstration of whether activation of (Na+ + K+)-ATPase affects heart function in animal in vivo was the ob...

journal_title：Biochemical and biophysical research communications

authors： Xu KY,Takimoto E,Fedarko NS

更新日期：2006-10-20 00:00:00

abstract：:We examined age-associated changes of respiratory enzyme activities and protein synthesis in mitochondria isolated from mouse brain with high oxidative activities. Cytochrome c oxidase activity increased unexpectedly with aging, while the mitochondrial translational activities showed two phases of alterations: they in...

journal_title：Biochemical and biophysical research communications

authors： Takai D,Inoue K,Shisa H,Kagawa Y,Hayashi J

更新日期：1995-12-14 00:00:00

abstract：:A great challenge for gene therapy is to develop a high efficient gene delivery system with low toxicity. Nonviral vectors are still attractive although the current agents displayed some disadvantages (i.e., low transfection efficiency, high toxicity). To overcome the high toxicity of poly(ethylene imine) (PEI) and lo...

journal_title：Biochemical and biophysical research communications

authors： Liang B,He ML,Xiao ZP,Li Y,Chan CY,Kung HF,Shuai XT,Peng Y

更新日期：2008-03-21 00:00:00

abstract：:Immunoblot analysis of the conditioned medium of v-Ha-ras-transformed NIH3T3 cells showed that Ras protein is secreted in the culture fluid. Because cathepsins L and B whose activities are inhibited by Ras are also secreted, possible association between Ras and cathepsins was investigated by immunoprecipitation and fo...

journal_title：Biochemical and biophysical research communications

authors： Hiwasa T,Kominami E

更新日期：1995-11-22 00:00:00

abstract：:It is now well established that PA is a potent biological response modifier, showing simultaneously antitumor, antitoxic, anticarcinogenic, antifungal, antiparasitic and immunomodulatory properties. Since PA is a foreign protein, it is quite logical to assume that it may be cleaved into smaller peptide fragments in vi...

journal_title：Biochemical and biophysical research communications

authors： Sinha P,Sengupta J,Ray PK

更新日期：1999-04-29 00:00:00

abstract：:Incubation of purified protein kinase C with H2O2 results in the generation of a persistently activated form of the enzyme which is no longer dependent on Ca2+ or lipid cofactors. This oxidative activation of purified protein kinase C requires added Fe2+ in the incubation medium. Treatment of the soluble fraction of h...

journal_title：Biochemical and biophysical research communications

authors： Palumbo EJ,Sweatt JD,Chen SJ,Klann E

更新日期：1992-09-30 00:00:00

abstract：:Erythroid band 4.1 enhances the binding of erythroid spectrin to phosphatidylserine vesicles under conditions of ionic strength and at protein concentrations similar to those in the red cell. The extent of enhancement depends on the concentration of band 4.1; at 2 microM 4.1, spectrin binding increases approximately 1...

journal_title：Biochemical and biophysical research communications

authors： Takeshita K,MacDonald RI,MacDonald RC

更新日期：1993-02-26 00:00:00

abstract：:Dysregulation of microRNAs has been demonstrated to be involved in a variety of biological events related to cancer, including proliferation, metastasis, angiogenesis and immune escape. MiR-616-3p is located on the chromosome region 12q13.3, however, its potential role and clinical implications in gastric cancer remai...

journal_title：Biochemical and biophysical research communications

authors： Wu ZH,Lin C,Liu CC,Jiang WW,Huang MZ,Liu X,Guo WJ

更新日期：2018-07-02 00:00:00

abstract：:Four small ubiquitin-related modifier (SUMO) genes have been identified in humans. However, little is known about the basic biology of SUMO-4. Here, we report that SUMO-4 differs from SUMO-1, -2, and -3 in that the maturation process of SUMO-4 to active form containing C-terminal di-glycine residues is inhibited by a ...

journal_title：Biochemical and biophysical research communications

authors： Owerbach D,McKay EM,Yeh ET,Gabbay KH,Bohren KM

更新日期：2005-11-18 00:00:00

abstract：:The postnatal development and molecular properties of somatostatin receptor were studied in rat cerebral cortex. With [125I-Tyr11]SRIF as a radiolabeled ligand, the specific ligand binding to crude membrane increased transiently in the early phase of postnatal development and then decreased. This increase of somatosta...

journal_title：Biochemical and biophysical research communications

authors： Kimura N

更新日期：1989-04-14 00:00:00

abstract：:Ras can become activated via multiple distinct receptors in T lymphocytes. However, mechanistic studies of Ras signaling in normal T cells have been hampered by the lack of an efficient technology for gene transfer into resting post-thymic cells. We have overcome this limitation by utilizing adenoviral transduction of...

journal_title：Biochemical and biophysical research communications

authors： Marks RE,Ho AW,Rivas F,Marshall E,Janardhan S,Gajewski TF

更新日期：2003-12-19 00:00:00

abstract：:Low-molecular-weight metabolites in human milk are gaining increasing interest in studies of infant nutrition. In the present study, the milk metabolome from a single mother was explored at different stages of lactation. Metabolites were extracted from sample aliquots using either methanol/water (MeOH/H2O) extraction ...

journal_title：Biochemical and biophysical research communications

authors： Wu J,Domellöf M,Zivkovic AM,Larsson G,Öhman A,Nording ML

更新日期：2016-01-15 00:00:00

abstract：:Leydig cells were purified from rat testes by discontinuous metrizamide density gradient and were shown to contain renin (EC 3.4.99.1), angiotensin-converting enzyme (dipeptidyl carboxypeptidase, (EC 3.4.15.1), and the peptide hormone angiotensins I, II and III as determined by the combined HPLC and radioimmunoassay. ...

journal_title：Biochemical and biophysical research communications

authors： Pandey KN,Misono KS,Inagami T

更新日期：1984-08-16 00:00:00

abstract：:Subcellular distribution of a novel annexin, annexin XI, was examined in rat tissues. As we have previously reported, annexin XI mainly localizes in nuclei of 3Y1, the rat embryonic fibroblast cell line; however, immunoperoxidase staining was not particularly nuclear in most of the tissues examined in adult rats. Nucl...

journal_title：Biochemical and biophysical research communications

authors： Mamiya N,Iino S,Mizutani A,Kobayashi S,Hidaka H

更新日期：1994-07-15 00:00:00

abstract：:The Z-DNA binding domain of human ADAR1 (Zα(ADAR1)) preferentially binds Z-DNA rather than B-DNA with high binding affinity. Here, we have carried out chemical shift perturbation and backbone dynamics studies of Zα(ADAR1) in the free form and in complex with three DNA duplexes, d(CGCGCG)(2), d(CACGTG)(2), and d(CGTACG...

journal_title：Biochemical and biophysical research communications

authors： Lee AR,Kim HE,Lee YM,Jeong M,Choi KH,Park JW,Choi YG,Ahn HC,Choi BS,Lee JH

更新日期：2012-11-09 00:00:00