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Peroxynitrite reacts with biological nitrogen-containing cyclic molecules by a radical pathway, as demonstrated by ultraweak luminescence coupled with ESR technique.

Abstract：

:Ultraweak luminescence (uwCL) was coupled with electron spin resonance to study the reactions of 3 heterocyclic compounds (tryptophan, serotonin and imidazole) with peroxynitrite at pH 8.7. Tryptophan and serotonin reacted with emission of a flash peak of light (5 s) followed by a long-living light emission of +/- 80 s. Addition of the spin trap 4-POBN at different intervals, after the beginning of reaction revealed that a short-living free radical was produced in the case of serotonin and imidazole, but that with tryptophan, the initial radical rearranged into a relatively long-living radical, which was still formed when 4-POBN was added after 55 s (decreasing phase of uwCL).

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Mouithys-Mickalad A,Kohnen S,Deby C,Noels AF,Lamy M,Deby-Dupont G

doi

10.1006/bbrc.1999.0805

subject

Has Abstract

pub_date

1999-06-07 00:00:00

pages

460-4

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(99)90805-7

journal_volume

259

pub_type

杂志文章

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