Peroxidative free radical formation and O-demethylation of etoposide(VP-16) and teniposide(VM-26).

abstract：:Human Protein tyrosine kinase 6 (PTK6)(EC:2.7.10.2), also known as the breast tumor kinase (BRK), is an intracellular non-receptor Src-related tyrosine kinase expressed five-fold or more in human breast tumors and breast cancer cell lines but its expression being low or completely absent from normal mammary gland. The...

journal_title：Biochemical and biophysical research communications

authors： Thakur MK,Birudukota S,Swaminathan S,Battula SK,Vadivelu S,Tyagi R,Gosu R

更新日期：2017-01-22 00:00:00

abstract：:NGA is a human melanoma-associated antigen recognized by a panel of murine monoclonal antibodies developed in this laboratory. NGA consists of a 23.5 kDa core protein which is glycosylated in vivo to give a family of glycoproteins (30-60 kDa). Treatment of human melanoma G361 cells with the phorbol ester PMA resulted ...

journal_title：Biochemical and biophysical research communications

authors： Feyles V,Dixon WT,Sikora LK,Jerry LM

更新日期：1989-02-15 00:00:00

abstract：:The patch clamp technique applied to canine atrial myocyte sarcolemma, showed that 2 types of K+ channels were differentially affected by Ach. The 2 channel types differed in conductance, responses to [Ca++], and sensitivity to membrane potential. Addition of Ach (10(-9) M to 10(-6) M) to pipette solutions increased o...

journal_title：Biochemical and biophysical research communications

authors： Bubien JK,Woods WT Jr

更新日期：1987-02-13 00:00:00

abstract：:Biochemical and morphological techniques were used to investigate the GTP-binding proteins of clathrin-coated vesicles. Binding of [3H]GTP to clathrin coats was demonstrated by electron microscopic autoradiography. Purified coated vesicles bound 5.2 pmol [35S]GTP gamma S/mg protein. Addition of GTP or GTP gamma S, but...

journal_title：Biochemical and biophysical research communications

authors： Lenhard JM,Levy MA,Stahl PD

更新日期：1991-01-15 00:00:00

abstract：:Partially purified trehalose phosphorylase (EC 2.4.1.64) from Euglena gracilis SM-ZK was inhibited by fructose 2,6-bisphosphate in both synthetic and degradative directions. Ki value for trehalose phosphorolysis was 1.2 microM and that for trehalose synthesis was 0.5 microM. Functions of fructose 2,6-bisphosphate in E...

journal_title：Biochemical and biophysical research communications

authors： Miyatake K,Kuramoto Y,Kitaoka S

更新日期：1984-08-16 00:00:00

abstract：:A spontaneous lymphoma was detected in mice, which was caused by a recessive autosomal mutation. The genetic basis was revealed to be a 5-bp deletion at the splicing donor site of the first intron of the FasL gene, resulting in aberrant transcripts coding for non-functional proteins. This mutation of the FasL gene cau...

journal_title：Biochemical and biophysical research communications

authors： Wang CC,Zeng Q,Hwang LA,Guo K,Li J,Liew HC,Hong W

更新日期：2006-10-13 00:00:00

abstract：:Prostaglandin E(2) (PGE(2)) enhances the mitogenic response to epidermal growth factor (EGF) in hepatocytes, but the underlying mechanisms are not clear. We previously observed that PGE(2) upregulates EGF-induced signalling in the MEK/ERK and PI3K/Akt pathways in hepatocytes. Other investigations have indicated that E...

journal_title：Biochemical and biophysical research communications

authors： Ødegård J,Aasrum M,Tveteraas IH,Bharath SP,Sandnes D,Christoffersen T

更新日期：2012-05-04 00:00:00

abstract：:The aim of this study was to determine molecular mechanism(s) responsible for the reduced thymidine kinase activity (TK) observed earlier in an arabinosylcytosine (araC) resistant lymphoid cell line (H9-araC cells), which was obtained following continuous cultivation of H9 cells in the presence of 0.5 microM araC. Com...

journal_title：Biochemical and biophysical research communications

authors： Han T,Fernandez M,Sarkar M,Agarwal RP

更新日期：2003-08-01 00:00:00

abstract：:The circular RNA (circRNA) circEPSTI1 has been recently identified as a new cancer-associated circRNA in multiple types of cancer. However, the involvement of circEPSTI1 in non-small cell lung cancer (NSCLC) remains unexplored. The purpose of this study was to explore the expression pattern and function of circEPSTI1 ...

journal_title：Biochemical and biophysical research communications

authors： Yang T,Li M,Li H,Shi P,Liu J,Chen M

更新日期：2020-09-10 00:00:00

abstract：:Attachment of leukocytes to the vascular endothelium and the subsequent migration of cells into the vessel wall are early events in atherogenesis. This process requires the expression of endothelial adhesion molecules. Since tea catechins are reputed to promote antiatherogenic activities, we investigated the effects o...

journal_title：Biochemical and biophysical research communications

authors： Ludwig A,Lorenz M,Grimbo N,Steinle F,Meiners S,Bartsch C,Stangl K,Baumann G,Stangl V

更新日期：2004-04-09 00:00:00

abstract：:Human placental poly(ADP-ribose) polymerase was purified and the NH2-terminal amino acid sequences of 16 KDa and 40 KDa chymotryptic peptides were determined. Screening of a lambda gt11 cDNA library of normal human placenta with a 51-mer oligodeoxyribonucleotide yielded one clone with a 1.8 Kb insert and two clones wi...

journal_title：Biochemical and biophysical research communications

authors： Suzuki H,Uchida K,Shima H,Sato T,Okamoto T,Kimura T,Miwa M

更新日期：1987-07-31 00:00:00

abstract：:DMBA-induced rat mammary tumors were used to study the possible association of phosphoinositide phosphorylation to tumor growth. These membranous enzymatic activities were measured during various stages of tumor growth induced by pharmacological manipulation of plasma prolactin level. An increase in phosphorylation of...

journal_title：Biochemical and biophysical research communications

authors： Sharoni Y,Teuerstein I,Levy J

更新日期：1986-01-29 00:00:00

abstract：:Transplantation of normal myoblasts into dystrophic muscles is a potential treatment for Duchenne muscular dystrophy (DMD). However, the success of such grafts is limited by the immune system responses. To avoid rejection problems, autologous transplantation of the patient's corrected myoblasts has been proposed. Regr...

journal_title：Biochemical and biophysical research communications

authors： Huard C,Moisset PA,Dicaire A,Merly F,Tardif F,Asselin I,Tremblay JP

更新日期：1998-07-30 00:00:00

abstract：:Lafora disease, a progressive myoclonus epilepsy, is an autosomal recessive disease caused in approximately 80% of cases by mutation of the EPM2A gene, which encodes a dual specificity protein phosphatase called laforin. In addition to its phosphatase domain, laforin contains an N-terminal carbohydrate-binding domain ...

journal_title：Biochemical and biophysical research communications

authors： Wang W,Roach PJ

更新日期：2004-12-17 00:00:00

abstract：:Biochemical properties of Type II restriction enzyme BanI were characterized. Kinetic parameters were evaluated and an enhancement of rate was observed when the recognition site was located in a more central position in the substrate, suggesting that BanI locates its recognition site by a sliding mechanism. As BanI ha...

journal_title：Biochemical and biophysical research communications

authors： Advani S,Roy KB

更新日期：2000-12-09 00:00:00

abstract：:The S. cerevisiae a-factor, YIIKGVFWDPAC(s-farnesyl)-OCH3, is one of two peptide mating pheromones which mediate cell-cell communication in S. cerevisiae. We previously reported that replacing Gly5 with D-Ala led to a 4-6 fold increase in activity while the L-Ala5 homolog was 4 to 16-fold less active than the wildtype...

journal_title：Biochemical and biophysical research communications

authors： Zhang YL,Dawe AL,Jiang Y,Becker JM,Naider F

更新日期：1996-07-16 00:00:00

abstract：:We present a method of partial purification of mitochondrial citrate transporter of the yeast Saccharomyces cerevisiae. Based on functional evidence of interaction between citrate transport and citrate synthase, we have used an affinity column containing pig heart citrate synthase (PHCS) for the purification. The puri...

journal_title：Biochemical and biophysical research communications

authors： Persson LO,Srere PA

更新日期：1992-02-28 00:00:00

abstract：:The adhesion of highly activated neutrophils to cerebral microvascular endothelial cells (MVECs) may contribute to disruption and hyperpermeability of the blood-brain barrier (BBB) after cardiac surgery with prolonged cardiopulmonary bypass (CPB). A correlation between CPB duration and neutrophil-mediated BBB damage h...

journal_title：Biochemical and biophysical research communications

authors： Schuller AM,Windolf J,Blaheta R,Cinatl J,Kreuter J,Wimmer-Greinecker G,Moritz A,Scholz M

更新日期：2005-04-08 00:00:00

abstract：:Relative orientation of recombination substrates, neo gene, strongly influenced homologous recombination events in a bovine papillomavirus shuttle vector. Between direct repeats, recombination occurred at a high frequency while between inverted repeats, it was rare. Double strand break near the mutation site increased...

journal_title：Biochemical and biophysical research communications

authors： Naito A,Kitamura Y,Yoshikura H

更新日期：1991-01-15 00:00:00

abstract：:Megakaryocytes isolated in high purity from guinea pigs produced thromboxane B2 in response to exogenously provided arachidonic acid. This production was inhibited by in vitro treatment with acetylsalicylic acid with a concentration response relationship similar to that seen in platelets. During in vitro culture, the ...

journal_title：Biochemical and biophysical research communications

authors： Walenga RW,Miller JL,Stuart MJ

更新日期：1984-03-30 00:00:00

abstract：:Platelet activation (cytosolic [Ca2+] increase, aggregation and ATP secretion) was induced with A1F-4. This agent presumably interacts with a G protein which appears to mediate the coupling of the receptors for Ca mobilizing hormones and phospholipase C. All the A1F-4 evoked responses were inhibited by treatment with ...

journal_title：Biochemical and biophysical research communications

authors： Doni MG,Deana R,Bertoncello S,Zoccarato F,Alexandre A

更新日期：1988-11-15 00:00:00

abstract：:A variant of annexin 3 (AX3) of apparent mass 36 kD has been detected in human monocytes using a specific immune serum directed against the original 33-kD form of AX3 purified from human placenta. This protein is not a phosphorylated or a glycosylated form of the 33-kD AX3 and its expression increased along monocytic ...

journal_title：Biochemical and biophysical research communications

authors： Le Cabec V,Russo-Marie F,Maridonneau-Parini I

更新日期：1992-12-30 00:00:00

abstract：:Four new basic proteins were isolated from horse eosinophils and purified. The eosinophils release these proteins after permeabilization with saponin and degranulation stimulized by guanosine 5'-O-thiotriphosphate. The proteins were separated and purified on a Superose P12- and a Mono S-column by fast protein liquid c...

journal_title：Biochemical and biophysical research communications

authors： Piller K,Portmann P

更新日期：1993-04-30 00:00:00

abstract：:The role of hepatic nuclear factor 1α (HNF-1α) and its response element in the expression of glutathione S-transferase A1 (GSTA1) was investigated in hepatocytes cells injury induced by acetaminophen (APAP). Treatment of hepatocytes with C2-ceramide exacerbated cells injury with GSTA1 mRNA level reducing. Contrastingl...

journal_title：Biochemical and biophysical research communications

authors： Li Y,Hao B,Muhammad I,Zhang Y,Yang Y,Shi C,Chang Y,Li R,Li C,Liu F

更新日期：2019-08-13 00:00:00

abstract：:Ganoderma lucidum (G. lucidum) is a popular medicinal mushroom that has been used as a home remedy for the general promotion of health and longevity in East Asia. The dried powder of G. lucidum, which was recommended as a cancer chemotherapy agent in traditional Chinese medicine, is currently popularly used worldwide ...

journal_title：Biochemical and biophysical research communications

authors： Stanley G,Harvey K,Slivova V,Jiang J,Sliva D

更新日期：2005-04-29 00:00:00

abstract：:Here we report that we could obtain a highly differentiated smooth muscle cell line by screening the expression of a-smooth muscle actin from p53 knook out mice aorta. This cell revealed extended bipolar shape and expressed h-caldesmon and calponin as well as a-smooth muscle actin as protein markers of differentiated ...

journal_title：Biochemical and biophysical research communications

authors： Ohmi K,Masuda T,Yamaguchi H,Sakurai T,Kudo Y,Katsuki M,Nonomura Y

更新日期：1997-09-08 00:00:00

abstract：:Long term function of human lung allografts is hindered by development of chronic rejection manifested as Bronchiolitis Obliterans Syndrome (BOS). We have previously identified the development of antibodies (Abs) following lung transplantation to K-alpha1-tubulin (KAT), an epithelial surface gap junction cytoskeletal ...

journal_title：Biochemical and biophysical research communications

authors： Tiriveedhi V,Angaswamy N,Weber J,Mohanakumar T

更新日期：2010-08-20 00:00:00

abstract：:Long-term glyburide therapy has been reported to improve glucose-induced insulin secretion in patients with NIDDM. We examined the effects of glyburide on the synthesis and release of insulin and insulin gene expression in isolated islets in vitro. Incubation with glyburide (500 ng/ml) significantly increased insulin ...

journal_title：Biochemical and biophysical research communications

authors： Yamato E,Ikegami H,Tahara Y,Fukuda M,Cha T,Kawaguchi Y,Fujioka Y,Noma Y,Shima K,Ogihara T

更新日期：1994-02-28 00:00:00

abstract：:The number of electrons involved in the more positive of the two redox couples of the iron-molybdenum cofactor of Azotobacter vinelandii nitrogenase has been investigated by controlled potential coulometry in both the oxidizing and reducing directions. A n value of 1 was determined for interconversion of the oxidized ...

journal_title：Biochemical and biophysical research communications

authors： Schultz FA,Gheller SF,Newton WE

更新日期：1988-04-29 00:00:00

abstract：:Valine-to-isoleucine substitution at codon 180 of the prion protein gene is only observed in patients with Creutzfeldt-Jakob disease and accounts for approximately half of all cases of genetic prion disease in Japan. In the present study, we investigated the biochemical characteristics of valine-to-isoleucine substitu...

journal_title：Biochemical and biophysical research communications

authors： Ito Y,Sanjo N,Hizume M,Kobayashi A,Ohgami T,Satoh K,Hamaguchi T,Yamada M,Kitamoto T,Mizusawa H,Yokota T

更新日期：2018-02-19 00:00:00