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Clathrin-coated vesicles from human placenta contain GTP-binding proteins.

Abstract：

:Biochemical and morphological techniques were used to investigate the GTP-binding proteins of clathrin-coated vesicles. Binding of [3H]GTP to clathrin coats was demonstrated by electron microscopic autoradiography. Purified coated vesicles bound 5.2 pmol [35S]GTP gamma S/mg protein. Addition of GTP or GTP gamma S, but not ATP nor GMP, inhibited binding of [35S]GTP gamma S to intact coated vesicles and Triton X-100-extracted coats. A series of 23-24 kDa GTP-binding proteins with isoelectric points between pH 5-8 were detected in coated vesicles. We suggest that the low molecular weight ras-like GTP-binding protein(s) play a role in regulating vesicle-mediated protein transport or signal transduction within intracellular organelles.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Lenhard JM,Levy MA,Stahl PD

doi

10.1016/0006-291x(91)90505-2

subject

Has Abstract

pub_date

1991-01-15 00:00:00

pages

197-203

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(91)90505-2

journal_volume

174

pub_type

杂志文章

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