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Synthetic cyclohexenyl chalcone natural products possess cytotoxic activities against prostate cancer cells and inhibit cysteine cathepsins in vitro.

Abstract：

:A number of cyclohexenyl chalcone Diels-Alder natural products possess promising biological properties including strong cytotoxicity in various human cancer cells. Herein, we show that natural products in this class including panduratin A and nicolaioidesin C inhibit cysteine cathepsins as indicated by protease profiling assays and cell-free cathepsin L enzyme assays. Owing to the critical roles of cathepsins in the biology of human tumor progression, invasion, and metastasis, these findings should pave the way for development of novel antitumor agents for use in clinical settings.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Deb Majumdar I,Devanabanda A,Fox B,Schwartzman J,Cong H,Porco JA Jr,Weber HC

doi

10.1016/j.bbrc.2011.11.052

subject

Has Abstract

pub_date

2011-12-16 00:00:00

pages

397-402

issue

3-4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(11)02066-3

journal_volume

416

pub_type

杂志文章

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