当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Protein arginine methyltransferase 6 specifically methylates the nonhistone chromatin protein HMGA1a.

Protein arginine methyltransferase 6 specifically methylates the nonhistone chromatin protein HMGA1a.

Abstract：

:The HMGA family proteins HMGA1a and HMGA1b are nuclear nonhistone species implicated in a wide range of cellular processes including inducible gene transcription, modulation of chromosome structure through nucleosome and chromosome remodeling, and neoplastic transformation. HMGA proteins are highly modified, and changes in their phosphorylation states have been correlated with the phase of the cell cycle and changes in their transcriptional activity. HMGA1a is also methylated in the first DNA-binding AT-hook at Arg25 and other sites, although the enzyme or enzymes responsible have not been identified. We demonstrate here that a GST fusion of protein arginine methyltransferase 6 (PRMT6) specifically methylates full-length recombinant HMGA1a protein in vitro. Although GST fusions of PRMT1 and PRMT3 were also capable of methylating the full-length HMGA1a polypeptide, they recognize its proteolytic degradation products much better. GST fusions of PRMT4 or PRMT7 were unable to methylate the full-length protein or its degradation products. We conclude that PRMT6 is a good candidate for the endogenous enzyme responsible for HGMA1a methylation.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Miranda TB,Webb KJ,Edberg DD,Reeves R,Clarke S

doi

10.1016/j.bbrc.2005.08.179

subject

Has Abstract

pub_date

2005-10-28 00:00:00

pages

831-5

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(05)01898-X

journal_volume

336

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • The mitogaligin protein is addressed to the nucleus via a non-classical localization signal.

    abstract：:Mitogaligin, a protein encoded by galig, an internal cytotoxic gene of the galectin-3 locus, is mostly a mitochondrial protein. Mitochondrial targeting is due to an already identified mitochondrial localization signal. Interaction of mitogaligin with mitochondria leads to cytochrome c cytosolic leakage and ultimately ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.12.162

    authors： Robinet P,Mollet L,Gonzalez P,Normand T,Charpentier S,Brulé F,Dubois M,Legrand A

    更新日期：2010-01-29 00:00:00

  • Singlet oxygen production from the peroxidase catalyzed formation of styrene glutathione adducts.

    abstract：:Recently, Stock et al. (J. Biol. Chem. 261, 15915-15922 [1986]) described a model enzyme system composed of horseradish peroxidase, hydrogen peroxide, phenol, glutathione and styrene. This system forms glutathione-styrene conjugates. Glutathione radicals and carbon-centered radicals are intermediates in this process. ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(89)92215-8

    authors： Kanofsky JR

    更新日期：1989-03-31 00:00:00

  • Neuromedin N: a novel neurotensin-like peptide identified in porcine spinal cord.

    abstract：:A novel neurotensin-like peptide, designated neuromedin N, has been isolated from porcine spinal cord by using a bioassay for a stimulant effect on guinea pig ileum. By microsequencing, the amino acid sequence of the peptide has been determined to be Lys-Ile-Pro-Tyr-Ile-Leu, which is found to be quite homologous to th...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(84)80067-4

    authors： Minamino N,Kangawa K,Matsuo H

    更新日期：1984-07-31 00:00:00

  • Sialyl Lewis X moiety on rat polymorphonuclear leukocytes responsible for binding to rat E-selectin.

    abstract：:We investigated the presence of the carbohydrate ligand for E-selectin on the cell surface of rat polymorphonuclear leukocytes (PMN). Rat PMN, isolated from peripheral blood, adhered to recombinant rat E-selectin-coated microplates. The adhesion was inhibited either by an anti-rat E-selectin monoclonal antibody (MAb),...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.2499

    authors： Misugi E,Kawamura N,Imanishi N,Tojo SJ,Morooka S

    更新日期：1995-10-13 00:00:00

  • Hydration of sodium hyaluronate, NMR study of an oriented sample.

    abstract：:A sample of highly oriented Na-hyaluronate was prepared with a wet--spinning method and equilibrated to 75% relative humidity. Its proton NMR spectrum was recorded as a function of the angle theta between the hyaluronate helix axis and the external magnetic field. It appeared as a singlet with an angle-dependent line ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(86)80336-9

    authors： Lahajnar G,Rupprecht A

    更新日期：1986-11-26 00:00:00

  • Role of actin binding protein phosphorylation in platelet cytoskeleton assembly.

    abstract：:Actin binding protein from human blood platelets is shown to exist in the resting platelet as a phosphorylated protein and contains two residues of phosphate per 260,000 kd. Removal of one-half of these residues with E. coli alkaline phosphatase results in the loss of its ability to crosslink F-actin into a low speed ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(84)91332-9

    authors： Zhuang QQ,Rosenberg S,Lawrence J,Stracher A

    更新日期：1984-01-30 00:00:00

  • Actin cytoskeletons regulate the stretch-induced increase of Ca2+ current in human gastric myocytes.

    abstract：:Using the whole-cell and single channel recording techniques, the influence of actin cytoskeletons on L-type Ca2+ current was investigated in human gastric smooth muscle cells. In isotonic condition, an actin depolymerizer cytochalasin D (Cyt-D) markedly decreased the whole-cell current (I(Ba)) without changing steady...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.11.051

    authors： Kim JH,Rhee PL,Kang TM

    更新日期：2007-01-12 00:00:00

  • Transplasma membrane redox stimulates HeLa cell growth.

    abstract：:Impermeable ferricyanide stimulates the growth of HeLa cells in absence of fetal bovine serum or other growth factors. A series of impermeable oxidants with redox potentials down to -125 mV stimulate equivalent growth. All of these oxidants are reduced by the transplasma membrane electron transport system. Oxidants wi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(84)90588-6

    authors： Sun IL,Crane FL,Löw H,Grebing C

    更新日期：1984-12-14 00:00:00

  • Calmodulin-binding proteins of calcium-independent type in rat brain synaptosomal membranes: their localization and properties.

    abstract：:Some properties of calmodulin(CaM)-binding proteins (CaMBPs) of the Ca(2+)-independent type were investigated in the synaptosomal membrane (SM) from rat brain using the [125I]CaM gel overlay method. When SM was prepared in the presence of Ca2+, Ca(2+)-independent CaM binding was decreased, whereas the Ca(2+)-dependent...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(92)90543-t

    authors： Natsukari N,Miwa A,Fujita M

    更新日期：1992-03-16 00:00:00

  • Deletion-mutant epidermal growth factor receptor in human gliomas: effects of type II mutation on receptor function.

    abstract：:Malignant human glioma D-298 MG amplifies a rearranged epidermal growth factor receptor (EGFR) gene (c-erbB proto-oncogene), resulting in an in-frame deletion of 83 amino acids in domain IV of the extracellular domain of the EGFR. EGF and transforming growth factor-a (TGF-a) bound to the mutant EGFR with high affinity...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(91)91051-d

    authors： Humphrey PA,Gangarosa LM,Wong AJ,Archer GE,Lund-Johansen M,Bjerkvig R,Laerum OD,Friedman HS,Bigner DD

    更新日期：1991-08-15 00:00:00

  • Identification of a novel growth hormone binding protein mRNA in rat liver.

    abstract：:The presence of highly specific serum binding proteins for growth hormone (GH) has been well characterized in many species. In the rat the major growth hormone-binding protein (GH-BP) is a truncated, variant form of the target tissue GH receptor and is derived by an alternative mRNA splicing event. The GHBP mRNA is co...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(05)81091-5

    authors： Tiong TS,Herington AC

    更新日期：1991-10-31 00:00:00

  • The site of substrate and fructose 2,6-bisphosphate binding to rabbit liver fructose-1,6-bisphosphatase.

    abstract：:The binding site(s) in rabbit liver fructose-1,6-bisphosphatase for the active site binding ligand, fructose 6-phosphate, and the inhibitor, fructose 2,6-bisphosphate, have been investigated by using nuclear magnetic resonance spectroscopy. The distance from a nitroxide spin label to the bound ligands and the distance...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(89)92654-5

    authors： Liu F,Roy M,Fromm HJ

    更新日期：1989-06-15 00:00:00

  • Transcription factor levels in medullary thyroid carcinoma cells differentiated by Harvey ras oncogene: c-jun is increased.

    abstract：:In the TT cell line of human medullary thyroid carcinoma, the viral Harvey ras (v-rasH) oncogene induces differentiation, marked by morphological changes, diminution of growth, and increased expression of the calcitonin gene. Here, we show that the transcriptional factor c-jun is increased during v-rasH induced differ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(90)91251-m

    authors： Nelkin BD,Borges M,Mabry M,Baylin SB

    更新日期：1990-07-16 00:00:00

  • Hrp3, a chromodomain helicase/ATPase DNA binding protein, is required for heterochromatin silencing in fission yeast.

    abstract：:Hrp3, a paralog of Hrp1, is a novel member of the CHD1 (chromo-helicase/ATPase-DNA binding 1) protein family of Schizosaccharomyces pombe. Although it has been considered that CHD1 proteins are required for chromatin modifications in transcriptional regulations, little is known about their roles in vivo. In this study...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(02)00797-0

    authors： Jae Yoo E,Kyu Jang Y,Ae Lee M,Bjerling P,Bum Kim J,Ekwall K,Hyun Seong R,Dai Park S

    更新日期：2002-07-26 00:00:00

  • Digeranyl bisphosphonate inhibits geranylgeranyl pyrophosphate synthase.

    abstract：:A primary cellular target of the clinical nitrogenous bisphosphonates is the isoprenoid biosynthetic pathway. Specifically these drugs inhibit the enzyme farnesyl pyrophosphate synthase and deplete cells of larger isoprenoids. Inhibition of this enzyme results in impaired processing of both farnesylated and geranylger...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.12.094

    authors： Wiemer AJ,Tong H,Swanson KM,Hohl RJ

    更新日期：2007-02-23 00:00:00

  • Induction of endogenous glutathione by the chemoprotective agent, 3H-1,2-dithiole-3-thione, in human neuroblastoma SH-SY5Y cells affords protection against peroxynitrite-induced cytotoxicity.

    abstract：:Substantial evidence suggests that peroxynitrite generated from the bi-radical reaction of nitric oxide and superoxide is critically involved in the pathogenesis of neurodegenerative disorders, such as Parkinson's disease. Reaction with sulfhydryl (SH)-containing molecules has been proposed to be a major detoxificatio...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.02.156

    authors： Cao Z,Hallur S,Qiu HZ,Peng X,Li Y

    更新日期：2004-04-16 00:00:00

  • Defective GATA-3 expression in Th2 LCR-deficient mice.

    abstract：:Th2 cell differentiation is critically influenced by transcription factor GATA-3 and by various cis-acting elements including enhancers, silencers and a locus control region (LCR) in the Th2 cytokine locus. Th2 LCR-deficient Th2 cells completely lost the expression of GATA-3 and the phosphorylation of STAT6. Histone 3...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.06.080

    authors： Hwang SS,Kim K,Lee GR

    更新日期：2011-07-15 00:00:00

  • Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells.

    abstract：:ABCG2 (also called MXR (3), BCRP (4), or ABCP (5) is a recently-identified ABC half-transporter, which causes multidrug resistance in cancer. Here we report that the expression of the ABCG2 protein in Sf9 insect cells resulted in a high-capacity, vanadate-sensitive ATPase activity in isolated membrane preparations. AB...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.5130

    authors： Ozvegy C,Litman T,Szakács G,Nagy Z,Bates S,Váradi A,Sarkadi B

    更新日期：2001-07-06 00:00:00

  • MicroRNA-21 promotes osteogenesis of bone marrow mesenchymal stem cells via the Smad7-Smad1/5/8-Runx2 pathway.

    abstract：:Bone marrow mesenchymal stem cells (BMMSCs) are pluripotent stem cells, and the osteogenic differentiation of BMMSCs has been drawing attention for a long time. Bone formation is regulated by numerous molecular and cellular signaling pathways, and the differentiation of BMMSCs is controlled by a well-defined genetic p...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.09.119

    authors： Li X,Guo L,Liu Y,Su Y,Xie Y,Du J,Zhou J,Ding G,Wang H,Bai Y,Liu Y

    更新日期：2017-11-18 00:00:00

  • Modification of glutamine synthetase in Streptomyces griseus by ADP-ribosylation and adenylylation.

    abstract：:Addition of NH4+ to STreptomyces griseus 2682 cells grown in NO3- containing medium resulted in a rapid decline in glutamine synthetase activity due to covalent modification of the enzyme. The NH4+ promoted inactivation of the enzyme was inhibited by the ADP-ribosyltransferase inhibitor 3-methoxybenzamide. In the pres...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.2501

    authors： Penyige A,Kálmánczhelyi A,Sipos A,Ensign JC,Barabás G

    更新日期：1994-10-28 00:00:00

  • Adipocytes recognize and degrade oxidized low density lipoprotein through CD36.

    abstract：:CD36 expressed on adipocytes is thought to function as a fatty acid transporter (FAT). Here we report that adipocytes can endocytose and lysosomally degrade OxLDL, mainly mediated by CD36. Mouse 3T3-L1 preadipocytes showed marked increase in uptake and degradation of (125)I-OxLDL during their differentiation to adipoc...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(02)00666-6

    authors： Kuniyasu A,Hayashi S,Nakayama H

    更新日期：2002-07-12 00:00:00

  • Caenorhabditis elegans development requires mitochondrial function in the nervous system.

    abstract：:The mitochondrial respiratory chain (MRC) supplies the majority of the energy requirements of most eucaryotic cells. A null mutation in the Caenorhabditis elegans nuo-1 gene encoding a subunit of complex I (NADH-ubiquinone oxidoreductase) is lethal, leading to a developmental arrest at the third larval stage. To ident...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.05.108

    authors： Ndegwa S,Lemire BD

    更新日期：2004-07-09 00:00:00

  • Vitamin E attenuates silver nanoparticle-induced effects on body weight and neurotoxicity in rats.

    abstract：:Silver nanoparticles (AgNPs) are one of the most commonly used nanomaterials; however, it remains unclear whether AgNPs induce neurotoxicity. Here, we investigated the potential neurological effects of AgNPs and the neuroprotective effect of vitamin E (VE). We found that intranasal instillation of AgNPs in neonatal Sp...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.01.130

    authors： Yin N,Yao X,Zhou Q,Faiola F,Jiang G

    更新日期：2015-03-06 00:00:00

  • Effect of interleukin-11 on the levels of mRNAs encoding heme oxygenase and haptoglobin in human HepG2 hepatoma cells.

    abstract：:Effect of recombinant human interleukin-11 (rhIL-11) on the expression of transcripts encoding microsomal heme oxygenase (HO), the rate-limiting enzyme in heme catabolism, and haptoglobin (Hpt), a major acute-phase protein, were examined in human HepG2 hepatoma cells. Treatment of HepG2 cells with rhIL-11 elicited an ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.1623

    authors： Fukuda Y,Sassa S

    更新日期：1993-05-28 00:00:00

  • The IRI release from insulin gene-transduced hepatic cells responds to ambient glucose concentration.

    abstract：:Insulin gene was induced into differentiated hepatic cell line. These cells released immunoreactive insulin (IRI) of which molecular weight was greater than mature insulin. The secretion of IRI was responsive to glucose concentration and inhibited by glucose metabolism antagonist, 2-deoxy glucose (2-DOG). The mRNA of ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1997.6445

    authors： Hayashi M,Taguchi M,Fujita T

    更新日期：1997-04-17 00:00:00

  • FBXO11 represses cellular response to hypoxia by destabilizing hypoxia-inducible factor-1α mRNA.

    abstract：:The transcriptional factor hypoxia-inducible factor-1α (HIF-1α) is induced under hypoxia and plays crucial roles in cancer progression and angiogenesis. Protein arginine methyltransferases (PRMTs), 11 isoforms of which have been identified so far, modulates the functions of diverse proteins by catalyzing arginine meth...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.07.037

    authors： Ju UI,Park JW,Park HS,Kim SJ,Chun YS

    更新日期：2015-09-04 00:00:00

  • Comparison of mucosal absorption-enhancing activity between a claudin-3/-4 binder and a broadly specific claudin binder.

    abstract：:Intercellular spaces between adjacent mucosal epithelial cells are sealed by tight junctions (TJs) that prevent the free movement of solutes across the epithelium. Claudins (CLs), a family of 27 integral membrane proteins, are essential components for TJ seals. We previously used a CL-3/-4 binder, the C-terminal fragm...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.05.060

    authors： Matsuhisa K,Kondoh M,Suzuki H,Yagi K

    更新日期：2012-06-29 00:00:00

  • Tissue distribution and subcellular localization of a variant form of the human ST2 gene product, ST2V.

    abstract：:The human ST2 gene has been known to encode three splice variants; namely, a soluble secreted form of ST2, a transmembrane form of ST2L, and ST2V of undetermined localization. Therefore, analysis of tissue distribution and subcellular localization of ST2V is important to elucidate functional relationships among the th...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.5306

    authors： Tago K,Noda T,Hayakawa M,Iwahana H,Yanagisawa K,Yashiro T,Tominaga S

    更新日期：2001-08-03 00:00:00

  • Partial melting of the segment around pseudouridine in yeast 5S RNA.

    abstract：:Pseudouridine in yeast 5S RNA was modified with 4-bromomethyl-7-methoxy-coumarin(BMC). Temperature dependence of fluorescence intensity was measured at various concentrations of Mg2+ and K+ cations. Hyperchromicity was also measured. At 100mM KCl and 10mM Mg2+, fluorescence intensity decreased with temperature as free...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(83)91596-6

    authors： Nagamatsu K,Miyazawa Y

    更新日期：1983-07-18 00:00:00

  • Atrial natriuretic polypeptide in atria and plasma in experimental hyperthyroidism and hypothyroidism.

    abstract：:To investigate the involvement of thyroid hormone on the release of atrial natriuretic polypeptide (ANP), we have measured immunoreactive ANP in the atria and plasma of experimental hyperthyroid and hypothyroid rats. Plasma ANP was higher (p less than 0.05) in hyperthyroid rats and was lower (p less than 0.05) in hypo...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(86)90544-9

    authors： Kohno M,Takaori K,Matsuura T,Murakawa K,Kanayama Y,Takeda T

    更新日期：1986-01-14 00:00:00