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Vitamin E attenuates silver nanoparticle-induced effects on body weight and neurotoxicity in rats.

Abstract：

:Silver nanoparticles (AgNPs) are one of the most commonly used nanomaterials; however, it remains unclear whether AgNPs induce neurotoxicity. Here, we investigated the potential neurological effects of AgNPs and the neuroprotective effect of vitamin E (VE). We found that intranasal instillation of AgNPs in neonatal Sprague-Dawley rats caused significant body weight loss. Moreover, histological examinations revealed activation of neuroglial cells with concomitant destruction of the granular layer of the cerebellum. Furthermore, western blot analyses showed an increase in the levels of the glial fibrillary acidic protein (GFAP), a marker of astrocyte activation. These observations suggest that AgNPs have significant neurotoxic effects on the rat cerebellum. Strikingly, oral administration of VE counterbalanced the toxic effects triggered by AgNPs. Taken together, our findings suggest that nasal administration of AgNPs may produce neurotoxicity in rats, and that VE supplementation attenuates these effects.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Yin N,Yao X,Zhou Q,Faiola F,Jiang G

doi

10.1016/j.bbrc.2015.01.130

subject

Has Abstract

pub_date

2015-03-06 00:00:00

pages

405-10

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(15)00177-1

journal_volume

458

pub_type

杂志文章

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