Free calcium rise and mitogenesis in glial cells caused by endothelin.

abstract：:Overexpression of the ubiquitin-conjugating enzyme Cdc34 conferred strong cadmium resistance on budding yeast. Proteasome activity, which is involved in the degradation of ubiquitinated proteins, was not essential for the acquisition of resistance to cadmium. The overexpression of Cdc34 accelerated the ubiquitination ...

journal_title：Biochemical and biophysical research communications

authors： Hwang GW,Furuchi T,Naganuma A

更新日期：2007-11-23 00:00:00

abstract：:Since urease of Helicobacter pylori is essential for its colonization, we focused attention on foodstuffs which inhibit the activity of this enzyme. Among plant-derived 77 foodstuff samples tested, some tea and rosemary extracts were found to clearly inhibit H. pylori urease in vitro. In particular, green tea extract ...

journal_title：Biochemical and biophysical research communications

authors： Matsubara S,Shibata H,Ishikawa F,Yokokura T,Takahashi M,Sugimura T,Wakabayashi K

更新日期：2003-10-24 00:00:00

abstract：:Various subclasses of messenger ribonucleoprotein particles were prepared from free cytoplasmic and polysome fractions of rat liver on the basis of the homopolymeric content of the constituent RNA's. Two major proteins were evident in the free cytoplasmic preparations: the poly(A)-binding protein was the major constit...

journal_title：Biochemical and biophysical research communications

authors： Ford G,Nichols JL

更新日期：1984-05-16 00:00:00

abstract：:The degrading activity for human parathyroid hormone [hPTH-(1-84)] was studied in a rat osteoblast-like osteosarcoma cell line UMR106. At 37 C,UMR106 cells degraded hPTH-(1-84) into fragments in a time-dependent manner, which was shown by a radioimmunoassay with the use of antibody recognizing the C-terminal and middl...

journal_title：Biochemical and biophysical research communications

authors： Yamaguchi T,Baba H,Fukase M,Kinoshita Y,Fujimi T,Fujita T

更新日期：1986-12-15 00:00:00

abstract：:S100 proteins are acidic calcium-binding proteins present in high concentration in the brain and at lower concentrations in peripheral tissues. Their function remains to be elucidated in many tissues. In this report we show for the first time that S100 proteins stimulate the bovine photoreceptor membrane guanylate cyc...

journal_title：Biochemical and biophysical research communications

authors： Margulis A,Pozdnyakov N,Sitaramayya A

更新日期：1996-01-05 00:00:00

abstract：:Centromere protein F (CENPF) is an essential nuclear protein associated with the centromere-kinetochore complex and plays a critical role in chromosome segregation during mitosis. Up-regulation of CENPF expression has previously been detected in several solid tumors. In this study, we aim to study the expression and f...

journal_title：Biochemical and biophysical research communications

authors： Dai Y,Liu L,Zeng T,Zhu YH,Li J,Chen L,Li Y,Yuan YF,Ma S,Guan XY

更新日期：2013-07-12 00:00:00

abstract：:Intestinal brush border membranes prepared from pig jejunum were shown to transport intact reduced glutathione into an osmotically responsive intravesicular space. At early incubation time (under 1 min.) GSH was poorly hydrolysed in its free amino acids. Primarily glutathione uptake was obtained against a concentratio...

journal_title：Biochemical and biophysical research communications

authors： Linder M,De Burlet G,Sudaka P

更新日期：1984-09-28 00:00:00

abstract：:Carbohydrate response element binding protein (ChREBP) is responsible for conversion of dietary carbohydrate to storage fat in liver by coordinating expression of the enzymes that channel glycolytic pyruvate into lipogenesis. The activation of ChREBP in response to high glucose is nuclear localization and transcriptio...

journal_title：Biochemical and biophysical research communications

authors： Fukasawa M,Ge Q,Wynn RM,Ishii S,Uyeda K

更新日期：2010-01-08 00:00:00

abstract：:Activation of protein kinase C delta (PKCδ) has been linked to the neuroinflammation but the relationship with the various neurodegenerative diseases including the Alzheimer's disease (AD) was mostly elusive. In the AD brains, the special phospholipids, ethanolamine plasmalogens (Pls), were found to be reduced and our...

journal_title：Biochemical and biophysical research communications

authors： Sejimo S,Hossain MS,Akashi K

更新日期：2018-09-05 00:00:00

abstract：:A secondary structure has been predicted for the hemorrhagic metalloproteases using a method developed in Zurich that extracts structural information from patterns of conservation and variation in homologous protein sequences. This prediction tests the limits of the method when applied to a small number of homologous ...

journal_title：Biochemical and biophysical research communications

authors： Gerloff DL,Jenny TF,Knecht LJ,Benner SA

更新日期：1993-07-15 00:00:00

abstract：:Pluripotent embryonic stem (ES) cells are the most versatile cells, with the potential to differentiate into all types of cell lineages including neural precursor cells (NPCs), which can be expanded in large numbers for significant periods of time to provide a reliable cell source for transplantation in neurodegenerat...

journal_title：Biochemical and biophysical research communications

authors： Xu H,Fan X,Wu X,Tang J,Yang H

更新日期：2005-01-07 00:00:00

abstract：:The methylcoenzyme M methylreductase reaction has an absolute requirement for 7-mercaptoheptanoylthreonine phosphate or component B, which is the active component of the intact molecule previously referred to as cytoplasmic cofactor. A hydrolytic fragment of cytoplasmic cofactor has been purified and identified as uri...

journal_title：Biochemical and biophysical research communications

authors： Marsden BJ,Sauer FD,Blackwell BA,Kramer JK

更新日期：1989-03-31 00:00:00

abstract：:Administration of streptozotocin (STZ) induces destruction of β-cells and is widely used as an experimental animal model of type I diabetes. In neonatal rat, after low-doses of STZ-mediated destruction of β-cells, β-cells regeneration occurs and reversal of hyperglycemia was observed. However, in neonatal mice, β-cell...

journal_title：Biochemical and biophysical research communications

authors： Kataoka M,Kawamuro Y,Shiraki N,Miki R,Sakano D,Yoshida T,Yasukawa T,Kume K,Kume S

更新日期：2013-01-18 00:00:00

abstract：:We have previously reported the establishment of preadipocyte cell lines, termed dedifferentiated fat (DFAT) cells, from mature adipocytes of various animals. DFAT cells possess long-term viability and can redifferentiate into adipocytes both in vivo and in vitro. Furthermore, DFAT cells can transdifferentiate into os...

journal_title：Biochemical and biophysical research communications

authors： Kazama T,Fujie M,Endo T,Kano K

更新日期：2008-12-19 00:00:00

abstract：:Our results show that in the intact normal animal cell mitochondrial ATP is directly connected to nuclear PARP-1 by way of a specific adenylate kinase enzymatic path. This mechanism is demonstrated in two models: (a) by its inhibition with a specific inhibitor of adenylate kinase, and (b) by disruption of ATP synthesi...

journal_title：Biochemical and biophysical research communications

authors： Kun E,Kirsten E,Hakam A,Bauer PI,Mendeleyev J

更新日期：2008-02-08 00:00:00

abstract：:MicroRNAs (miRNAs) play important roles in the pathogenesis of many types of cancers by negatively regulating gene expression at posttranscriptional level. Here, we identified that miR-599 is up-regulated in non-small cell lung cancer (NSCLC) patients. It promoted NSCLC cell proliferation by negatively regulating SATB...

journal_title：Biochemical and biophysical research communications

authors： Tian W,Wang G,Liu Y,Huang Z,Zhang C,Ning K,Yu C,Shen Y,Wang M,Li Y,Wang Y,Zhang B,Zhao Y

更新日期：2017-03-25 00:00:00

abstract：:Multiple deletions of mtDNA have not only been implicated in aging, but also in a wide variety of pathological conditions. The enzyme system used in long-PCR makes it possible to synthesize the entire mitochondrial genome (16.5 kb), exposing the multiple deletions in mtDNAs implicated in and, at least partially, respo...

journal_title：Biochemical and biophysical research communications

authors： Reynier P,Malthiery Y

更新日期：1995-12-05 00:00:00

abstract：:We have isolated and characterized a cDNA and the gene of the human homologue of CAAF1, a novel member of the S100 calcium-binding protein family. The 276-bp open reading frame encoded a 92-amino acid polypeptide with a predicted molecular mass of 10,575 Da. The deduced amino acid sequence of human CAAF1 showed 66% ho...

journal_title：Biochemical and biophysical research communications

authors： Yamamura T,Hitomi J,Nagasaki K,Suzuki M,Takahashi E,Saito S,Tsukada T,Yamaguchi K

更新日期：1996-04-16 00:00:00

abstract：:Several populations of stem cells, including those from the dental pulp and periodontal ligament, have been isolated from different parts of the tooth and periodontium. The characteristics of such stem cells have been reported as well. However, as a common progenitor of these cells, ectomesenchymal stem cells (EMSCs),...

journal_title：Biochemical and biophysical research communications

authors： Wen X,Liu L,Deng M,Zhang L,Liu R,Xing Y,Zhou X,Nie X

更新日期：2012-10-12 00:00:00

abstract：:Osteoclasts are hematopoietic cells essential for bone resorption. To understand the process of osteoclastogenesis, we have developed a culture system that employs a stromal cell line, in which differentiation of osteoclasts from single embryonic stem (ES) cells occurs. This culture, which did not require any cell pas...

journal_title：Biochemical and biophysical research communications

authors： Hemmi H,Okuyama H,Yamane T,Nishikawa S,Nakano T,Yamazaki H,Kunisada T,Hayashi S

更新日期：2001-01-19 00:00:00

abstract：:Neurofibromatosis type 1 is a common genetic disease that causes nervous system tumors, and cognitive deficits. It is due to mutations within the NF1 gene, which encodes the Nf1 protein. Nf1 has been shown to be involved in the regulation of Ras, cAMP and actin cytoskeleton dynamics. In this study, using immunofluores...

journal_title：Biochemical and biophysical research communications

authors： Godin F,Villette S,Vallée B,Doudeau M,Morisset-Lopez S,Ardourel M,Hevor T,Pichon C,Bénédetti H

更新日期：2012-02-24 00:00:00

abstract：BACKGROUND:The prognosis of patients after acute kidney injury (AKI) is poor and treatment is limited. AKI is mainly caused by renal ischemia/reperfusion injury (IRI). During the extension phase of IRI, endothelial damage may participate in ischemia and inflammation. Endothelin-1 (ET-1) which is mostly secreted by endo...

journal_title：Biochemical and biophysical research communications

authors： Arfian N,Emoto N,Vignon-Zellweger N,Nakayama K,Yagi K,Hirata K

更新日期：2012-08-24 00:00:00

abstract：:Expression of the cytochrome P-450 monooxygenase activity 7-ethoxyresorufin O-deethylase (7-ERD) was surveyed in proliferating and quiescent cultures of murine cell line C-10, a non-tumorigenic line of presumed alveolar type II origin. 7-ERD activities were undetectable in subconfluent/proliferating cultures but becam...

journal_title：Biochemical and biophysical research communications

authors： Reiners JJ Jr,Pavone A,Cantu AR,Auerbach C,Malkinson AM

更新日期：1992-02-28 00:00:00

abstract：:Parkinson's disease (PD) is one of the most prevalent neurodegenerative diseases but its etiology is unclear. Alpha-synuclein (alpha-SN) is a major component of Lewy bodies and Lewy neurites, and its missense mutations, A30P and A53T, cause familial PD. In PD, alpha-SN-positive glial inclusions are distributed mainly ...

journal_title：Biochemical and biophysical research communications

authors： Kohno R,Sawada H,Kawamoto Y,Uemura K,Shibasaki H,Shimohama S

更新日期：2004-05-21 00:00:00

abstract：:Pancreatic adenocarcinoma is currently one of the leading causes of cancer-related death worldwide. The high rate of mortality in pancreatic cancer patients is due to the inability to detect early-stage disease and the disease being highly refractory to therapy. Gemcitabine has been the standard chemotherapy for advan...

journal_title：Biochemical and biophysical research communications

authors： Ahn HM,Kim DG,Kim YJ

更新日期：2020-06-25 00:00:00

abstract：:The c-Jun N-terminal Kinases (JNKs) play important roles in cell responses to stress or growth factor stimulation. The JNK1α1 isoform shares >90% identity with a predominantly neuronal JNK3α1 isoform, but JNK3α1 also includes a distinctive 38 amino acid N-terminal sequence. To address the outstanding question of the p...

journal_title：Biochemical and biophysical research communications

authors： Chen WK,Yeap YY,Bogoyevitch MA

更新日期：2014-10-24 00:00:00

abstract：:In this work, we examined the functions of the female hormone "estrogen" on spermatogenesis of the Japanese eel (Anguilla japonica). Estradiol-17beta (E(2)), a natural estrogen in vertebrates, was present in the serum and its receptor was expressed in the testis during the whole process of spermatogenesis. Spermatogon...

journal_title：Biochemical and biophysical research communications

authors： Miura T,Miura C,Ohta T,Nader MR,Todo T,Yamauchi K

更新日期：1999-10-14 00:00:00

abstract：:Chironomus ramosus is known to tolerate high doses of gamma radiation exposure. Larvae of this insect possess more than 95% of hemoglobin (Hb) in its circulatory hemolymph. This is a comparative study to see effect of gamma radiation on Hb of Chironomus and humans, two evolutionarily diverse organisms one having extra...

journal_title：Biochemical and biophysical research communications

authors： Gaikwad PS,Panicker L,Mohole M,Sawant S,Mukhopadhyaya R,Nath BB

更新日期：2016-08-05 00:00:00

abstract：:The recent release of COVID-19 spike glycoprotein allows detailed analysis of the structural features that are required for stabilizing the infective form of its quaternary assembly. Trying to disassemble the trimeric structure of COVID-19 spike glycoprotein, we analyzed single protomer surfaces searching for concave ...

journal_title：Biochemical and biophysical research communications

authors： Bongini P,Trezza A,Bianchini M,Spiga O,Niccolai N

更新日期：2020-07-12 00:00:00

abstract：:Bradykinin (BK) B2 receptor signaling involves activation of phospholipase C (PLC). PLC activation by other receptors consists of either allosteric activation of PLC beta isoforms by G-proteins or tyrosine phosphorylation of PLC gamma isoforms. Because the B2 receptor is a G-protein-coupled receptor, it has been assum...

journal_title：Biochemical and biophysical research communications

authors： Venema VJ,Ju H,Sun J,Eaton DC,Marrero MB,Venema RC

更新日期：1998-05-08 00:00:00